Relationship of Silent Cerebral Infarctions and White Matter Hyperintensities to Cognitive Performance in the Framingham Offspring Study

Bristow, Karrah Q.; Au, Rhoda; Massaro, Joseph M.; Seshadri, Sudha; Wolf, Philip A.; Kelly-Hayes, Margaret; DeCarli, Charles

doi:10.1097/00002093-200607001-00020

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2010

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“…This would suggest that there is a threshold value above which the effect of WMH can be seen clinically. A recent Framingham paper further suggests that the issue of WMH is complicated by concomitant SCI 8. Therefore, four study groups were identified based on MRI results: 1) those with SCI only (SCI-O); 2) those with large WMH volume only (WMH-L); 3) those with both SCI and WMH-L (SCI-WMH-L); 4) those with neither SCI nor WMH-L (No SCI-No WMH-L) 8…”

Section: Methodsmentioning

confidence: 99%

Profiles by Sex of Brain MRI and Cognitive Function in the Framingham Offspring Study

Albert

Massaro

DeCarli

et al. 2010

Alzheimer Disease &Amp; Associated Disorders

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Objective-To examine whether there are sex-specific associations between brain MRI measures and neuropsychological test performance.Background-Differences in cardiovascular risk factors (CVRF) have been linked to decreased total cerebral brain volume (TCBV) and white matter hyperintensities (WMH). Although brain morphology has been related to cognitive performance, few studies have addressed sex-specific effects in this relationship.

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Section: Methodsmentioning

confidence: 99%