Relationship of serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing postmenopausal breast cancer

Gordon, Gary; Tl, Bush; Kj, Helzlsouer; Миллер, С В; Comstock, Georgew .

doi:10.1016/0378-5122(91)90313-f

Cited by 41 publications

(49 citation statements)

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“…DHEA-S is more frequently studied in social science research because it has a longer half-life than DHEA and an absence of diurnal variation (Rosenfeld, Rosenberg, Fukushima, & Hellman, 1975). DHEA and DHEA-S appear to have protective functions against a variety of conditions, including HIV (Loria, Inge, Cook, Szakal, & Regelson, 1988), Cushing's disease (Yamaji, Ishibashi, Sekihara, Itabashi, & Yanaihara, 1984), Alzheimer's disease Affectionate Communication 8 (Näsman et al, 1995), and some forms of cancer (Gordon, Helzlsouer, & Comstock, 1991).…”

Section: Affectionate Communicationmentioning

confidence: 99%

Affectionate Communication Received from Spouses Predicts Stress Hormone Levels in Healthy Adults

Floyd¹,

Riforgiate

2008

Communication Monographs

114

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Section: Affectionate Communicationmentioning

confidence: 99%

Affectionate Communication Received from Spouses Predicts Stress Hormone Levels in Healthy Adults

Floyd¹,

Riforgiate

2008

Communication Monographs

114

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“…Results from at least 10 prospective cohort studies on breast cancer risk in relation to prediagnostic blood levels of sex steroids among postmenopausal women have been published (Wysowski et al 1987, BarrettConnor et al 1990, Gordon et al 1990, Garland et al 1992, Helzlsouer et al 1994, Toniolo et al 1995, Dorgan et al 1996, Thomas et al 1997a, Zeleniuch-Jacquotte et al 1997, Hankinson et al 1998, Cauley et al 1999, Kabuto et al 2000. However, most of these studies were based on rather small numbers of cases, were conducted in diverse populations in the USA, Europe and Japan, and used heterogeneous study protocols, blood collection procedures and laboratory methods for hormone assays.…”

Section: Introductionmentioning

confidence: 99%

Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition

Kaaks

Rinaldi

Key

et al. 2005

Endocr Relat Cancer

468

352

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Considerable experimental and epidemiological evidence suggests that elevated endogenous sex steroids -notably androgens and oestrogens -promote breast tumour development. In spite of this evidence, postmenopausal androgen replacement therapy with dehydroepiandrosterone (DHEA) or testosterone has been advocated for the prevention of osteoporosis and improved sexual wellbeing. We have conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Levels of DHEA sulphate (DHEAS), (D4-androstenedione), testosterone, oestrone, oestradiol and sex-hormone binding globulin (SHBG) were measured in prediagnostic serum samples of 677 postmenopausal women who subsequently developed breast cancer and 1309 matched control subjects. Levels of free testosterone and free oestradiol were calculated from absolute concentrations of testosterone, oestradiol and SHBG. Logistic regression models were used to estimate relative risks of breast cancer by quintiles of hormone concentrations. For all sex steroidsthe androgens as well as the oestrogens -elevated serum levels were positively associated with breast cancer risk, while SHBG levels were inversely related to risk. For the androgens, relative risk

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“…They also suggest that the contribution of androgens to risk is largely through their role as substrates for oestrogen production. Nine prospective studies have now reported on the association between endogenous sex hormone levels in postmenopausal women and subsequent breast cancer risk (Moore et al, 1986;Wysowski et al, 1987;Barrett-Connor et al, 1990;Gordon et al, 1990;Garland et al, 1992;Helzlsouer et al, 1994;Toniolo et al, 1995;Berrino et al, 1996;Dorgan et al, 1996;Thomas et al, 1997;Zeleniuch-Jacquotte et al, 1997;Hankinson et al, 1998;Cauley et al, 1999;Kabuto et al, 2000). The Endogenous Hormones and Breast Cancer Collaborative Group (TEHBCCG) conducted a pooled analysis of the original data of these studies and concluded that both oestrogen and androgen hormones were strongly associated with risk (TEHBCCG, 2002).…”

mentioning

confidence: 99%

Postmenopausal levels of oestrogen, androgen, and SHBG and breast cancer: long-term results of a prospective study

et al. 2004

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We assessed the association of sex hormone levels with breast cancer risk in a case -control study nested within the cohort of 7054 New York University (NYU) Women's Health Study participants who were postmenopausal at entry. The study includes 297 cases diagnosed between 6 months and 12.7 years after enrollment and 563 controls. Multivariate odds ratios (ORs) (95% confidence interval (CI)) for breast cancer for the highest quintile of each hormone and sex-hormone binding globulin (SHBG) relative to the lowest were as follows: 2.49 (1.47 -4.21), P trend ¼ 0.003 for oestradiol; 3.24 (1.87 -5.58), P trend o0.001 for oestrone; 2.37 (1.39 -4.04), P trend ¼ 0.002 for testosterone; 2.07 (1.28 -3.33), P trend o0.001 for androstenedione; 1.74 (1.05 -2.89), P trend o0.001 for dehydroepiandrosterone sulphate (DHEAS); and 0.51 (0.31 -0.82), P trend o0.001 for SHBG. Analyses limited to the 191 cases who had donated blood five to 12.7 years prior to diagnosis showed results in the same direction as overall analyses, although the tests for trend did not reach statistical significance for DHEAS and SHBG. The rates of change per year in hormone and SHBG levels, calculated for 95 cases and their matched controls who had given a second blood donation within 5 years of diagnosis, were of small magnitude and overall not different in cases and controls. The association of androgens with risk did not persist after adjustment for oestrone (1.08, 95% CI ¼ 0.92 -1.26 for testosterone; 1.15, 95% CI ¼ 0.95 -1.39 for androstenedione and 1.06, 95% CI ¼ 0.90 -1.26 for DHEAS), the oestrogen most strongly associated with risk in our study. Our results support the hypothesis that the associations of circulating oestrogens with breast cancer risk are more likely due to an effect of circulating hormones on the development of cancer than to elevations induced by the tumour. They also suggest that the contribution of androgens to risk is largely through their role as substrates for oestrogen production. Nine prospective studies have now reported on the association between endogenous sex hormone levels in postmenopausal women and subsequent breast cancer risk (Moore et al, 1986;Wysowski et al, 1987;Barrett-Connor et al, 1990;Gordon et al, 1990;Garland et al, 1992;Helzlsouer et al, 1994;Toniolo et al, 1995;Berrino et al, 1996;Dorgan et al, 1996;Thomas et al, 1997;Zeleniuch-Jacquotte et al, 1997;Hankinson et al, 1998;Cauley et al, 1999;Kabuto et al, 2000). The Endogenous Hormones and Breast Cancer Collaborative Group (TEHBCCG) conducted a pooled analysis of the original data of these studies and concluded that both oestrogen and androgen hormones were strongly associated with risk (TEHBCCG, 2002). Remaining questions include how long prior to diagnosis the associations between hormone levels and breast cancer are observed and whether androgens play a part independent of their role as substrates for oestrogen production. The New York University (NYU) Women's Health Study was one of the first prospective studies to report a positive association between ...

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Relationship of serum levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate to the risk of developing postmenopausal breast cancer

Cited by 41 publications

References 0 publications

Affectionate Communication Received from Spouses Predicts Stress Hormone Levels in Healthy Adults

Affectionate Communication Received from Spouses Predicts Stress Hormone Levels in Healthy Adults

Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition

Postmenopausal levels of oestrogen, androgen, and SHBG and breast cancer: long-term results of a prospective study

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