Relationship of serum gastrin response to lower oesophageal sphincter pressure.

Dent, John; Hansky, J.

doi:10.1136/gut.17.2.144

Cited by 14 publications

(8 citation statements)

References 9 publications

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“…Nevertheless, changes 102 secondary effects on gastrin release, and gastrin concentrations were measured during cimetidine infusion in the present studies. The role of gastrin as a physiological determinant of LOS pressure is now in debate, and the recent studies of Dent and Hansky (1976) and our own unpublished data, have failed to confirm earlier suggestions that gastrin is involved in LOS control (Giles et al, 1969;Castell and Harris, 1970;McCall et al, 1975). In any event, mean serum gastrin concentrations did not show any statistically significant variation from basal values (Fig.…”

Section: Discussionmentioning

confidence: 59%

Effect of cimetidine on the human lower oesophageal sphincter.

Osborne¹,

Lennon²,

Henderson³

et al. 1977

Gut

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SUMMARY Lower oesophageal sphincter pressures in healthy volunteers were measured by a rapid pull-through technique during intravenous infusion of the histamine H2-receptor antagonist, cimetidine. No consistent effects on sphincter pressure were observed which are liable to be of clinical importance. Serum gastrin concentrations during cimetidine infusion were measured by radioimmunoassay and showed no significant variation. In a further series of experiments, the response of the lower oesophageal sphincter to intravenous bolus injection of pentagastrin was measured before and during cimetidine infusion. Cimetidine infusion had no significant effect on the sphincter response to pentagastrin.

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Section: Discussionmentioning

confidence: 59%

Effect of cimetidine on the human lower oesophageal sphincter.

Osborne¹,

Lennon²,

Henderson³

et al. 1977

Gut

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“…Similarly, many of the studies reporting a rise in LOS pressure after protein feeding (Nebel and Castell, 1972;Lipshutz et al, 1973;Roszkowski et al, 1973) have assumed rather than demonstrated an effect on circulating gastrin levels. In studies which have included serum gastrin determinations there has been a varied temporal relationship between administration of the stimulus to gastrin release, the peak gastrin response, and the change in LOS pressure (Higgs et al, 1974;McCall et al, 1975;Dent and Hansky, 1976). Furthermore, while Dent and Hansky (1976) report a rise in LOS pressure 30 minutes after the peak gastrin response to protein instillation, a similar rise was observed after intragastric instillation of a control solution of saline, this time without accompanying variation in the serum gastrin concentrations.…”

Section: -mentioning

confidence: 99%

“…In studies which have included serum gastrin determinations there has been a varied temporal relationship between administration of the stimulus to gastrin release, the peak gastrin response, and the change in LOS pressure (Higgs et al, 1974;McCall et al, 1975;Dent and Hansky, 1976). Furthermore, while Dent and Hansky (1976) report a rise in LOS pressure 30 minutes after the peak gastrin response to protein instillation, a similar rise was observed after intragastric instillation of a control solution of saline, this time without accompanying variation in the serum gastrin concentrations. They concluded that the response of the LOS to feeding may be unrelated to protein and is not related to serum gastrin levels.…”

Section: -mentioning

confidence: 99%

“…There is no doubt that exogenous gastrin increases sphincter pressure (Giles et al, 1969;Cohen and Lipshutz, 1971;Trindade et al, 1975;Kaye et al, 1976) but the evidence that endogenous gastrin is a physiological determinant of sphincter pressure is less convincing (Grossman, 1973;Roszkowski et al, 1973;Farrell et al, 1974;McCall et al, 1975;Dodds et al, 1975a, b;Dent and Hansky, 1976). Central to the controversy is the methodology of LOS pressure measurement.…”

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confidence: 99%

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Lower oesophageal sphincter response to gastrin--pharmacological or physiological?

Henderson¹,

Lidgard²,

Osborne³

et al. 1978

Gut

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SUMMARY The response of the lower oesophageal sphincter (LOS) to intragastric instillation of protein was assessed in 10 healthy volunteers. Sphincter pressures were measured by a rapid pullthrough technique and serum gastrin concentrations during each test were determined by radioimmunoassay. Despite stimulation of gastrin release by protein instillation, no significant change in LOS pressure was observed. However, intravenous pentagastrin (0 25 and 0.5 jig/kg) produced an immediate increase in sphincter pressure, which then returned to the basal level within four minutes. Thus, although pentagastrin is an effective pharmacological stimulant of the sphincter, endogenous gastrin appears not to be a physiological determinant of LOS pressure in man.The role of endogenous gastrin in control of the lower oesophageal sphincter (LOS) is still a subject of controversy. There is no doubt that exogenous gastrin increases sphincter pressure (Giles et al., 1969;Cohen and Lipshutz, 1971;Trindade et al., 1975;Kaye et al., 1976) but the evidence that endogenous gastrin is a physiological determinant of sphincter pressure is less convincing (Grossman, 1973;Roszkowski et al., 1973;Farrell et al., 1974;McCall et al., 1975; Dodds et al., 1975a, b;Dent and Hansky, 1976). Central to the controversy is the methodology of LOS pressure measurement. Most studies have used static pressure recording catheters or a station pull-through technique in which the recording catheter is withdrawn across the sphincter in 1 cm steps, pausing after each step to record LOS pressure during three or four respiratory cycles. Rapid pull-through techniques are now available which minimise error in pressure recording (Dodds etal., 1975a(Dodds etal., , b 1976) and a rapid pull-through method was used in the present study to measure the LOS pressure response to endogenous gastrin release provoked by intragastric instillation of protein. Methods TECHNIQUE OF LOS PRESSURE MEASUREMENT LOS pressure was measured by a rapid pull-through technique based on that described by WaldeckReceived for publication 9 August 1977 (1972) and modified by Osborne and his colleagues (1977). Recordings were made with a single lumen polyvinyl tube which was perfused at 6 ml/min as it was withdrawn across the LOS at 0'9 cm/s. This system was capable of recording a pressure rise rate of 70 mmHg/s when tested on the bench. By convention, LOS pressure is measured as the peak height of the profile relative to intragastric pressure. RESPONSE OF LOS TO PENTAGASTRINFour healthy male volunteers (aged 26-32 years), without a previous history of dyspepsia, were given graded doses of pentagastrin (Peptavlon, ICI) to determine the LOS pressure response. Doses of 0'0625, 0 125, 0-25, and 0 5 jig/kg were used, the pentagastrin being diluted in 10 ml/150 mm sodium chloride solution and injected intravenously over 60 seconds. The four doses were given in a random order which was not known to the subject. LOS pressure was measured every two minutes for 10 minutes before pentagastrin injectio...

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“…Coffee stimulates gastrin production whereas caffeine has no such effect (2). The role of gastrin, however, in the control of LOSP is disputed (6). There is good evidence that it has an important role in the physiology of the lower oesophageal sphincter (8).…”

Section: Discussionmentioning

confidence: 99%

Effect of Coffee on Human Lower Oesophageal Function

Salmon¹,

Fedail²,

Würzner³

et al. 1981

Digestion

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The effect of coffee on lower oesophageal sphincter pressure (LOSP) and intra-oesophageal pH was assessed in 10 healthy volunteers, in the fasting state and after a standard Lundh test meal. LOSP was measured by the rapid pull-through technique. Coffee with or without milk has no significant effect on LOSP in the fasting subject. The Lundh meal alone (mean drop = 2.01 cm H₂O), or when coffee with (mean drop – 1.80 cm H₂O) or without milk (mean drop = 3.47 cm H₂O) was taken after it, produced a significant drop in LOSP. Heartburn following coffee does not appear to be due to an effect of coffee on the lower oesophageal sphincter but is more likely due to the effect of a previous meal on sphincter pressure with associated acid reflux.

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Relationship of serum gastrin response to lower oesophageal sphincter pressure.

Cited by 14 publications

References 9 publications

Effect of cimetidine on the human lower oesophageal sphincter.

Effect of cimetidine on the human lower oesophageal sphincter.

Lower oesophageal sphincter response to gastrin--pharmacological or physiological?

Effect of Coffee on Human Lower Oesophageal Function

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