Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study

Cho, Hanbyoul; Kim, Mi Kyung; Lee, Jae Kwan; Son, Soo Chang; Lee, Kwang Beom; Lee, Jong Min; Lee, Jung Pil; Hur, Soo Young; Kim, Jae Hoon

doi:10.1515/cclm.2009.221

Cited by 12 publications

(7 citation statements)

References 30 publications

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“…Epidemiological studies showed that high intake and high blood levels of zeaxanthin (alone or combined with lutein) might be associated with a lower risk of occurrence of various malignant tumors, including non-Hodgkin lymphoma [22, 23], cervical [24–28], esophagus [29–31], stomach [31, 32], lung [33–35], breast [34, 36–38, 42], kidney [39], head and neck [40], colon [41, 43] and pancreas [31, 44], cancers. …”

Section: Discussionmentioning

confidence: 99%

Zeaxanthin Induces Apoptosis in Human Uveal Melanoma Cells through Bcl-2 Family Proteins and Intrinsic Apoptosis Pathway

Rosen

Zha

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The cytotoxic effects of zeaxanthin on two human uveal melanoma cell lines (SP6.5 and C918) and related signaling pathways were studied and compared to effects on normal ocular cells (uveal melanocytes, retinal pigment epithelial cells, and scleral fibroblasts). MTT assay revealed that zeaxanthin reduced the cell viability of melanoma cells in a dose-dependent manner (10, 30, and 100 μM), with IC50 at 40.8 and 28.7 μM in SP6.5 and C918 cell lines, respectively. Zeaxanthin did not affect the viability of normal ocular cells even at the highest levels tested (300 μM), suggesting that zeaxanthin has a selectively cytotoxic effect on melanoma cells. Zeaxanthin induced apoptosis in melanoma cells as indicated by annexin V and ethidium III flow cytometry. Western blot analysis demonstrated that zeaxanthin decreased the expression of antiapoptotic proteins (Bcl-2 and Bcl-xL) and increased the expression of proapoptotic proteins (Bak and Bax) in zeaxanthin-treated melanoma cells. Zeaxanthin increased mitochondrial permeability as determined by JC-1 fluorescein study. Zeaxanthin also increased the level of cytosol cytochrome c and caspase-9 and -3 activities, but not caspase-8, as measured by ELISA assay or colorimetric assay. All of these findings indicate that the intrinsic (mitochondrial) pathway is involved in zeaxanthin-induced apoptosis in uveal melanoma cells.

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Section: Discussionmentioning

confidence: 99%

Zeaxanthin Induces Apoptosis in Human Uveal Melanoma Cells through Bcl-2 Family Proteins and Intrinsic Apoptosis Pathway

Rosen

Zha

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…For ever-smoking, 105 studies were initially identified, but many of them were excluded in the final analysis for several reasons: risk estimates with precision information (e.g., standard error, 95% confidence interval [CI]) were not available, the classification for smoking was different than never, former, and current smokers (53 studies), and multiple results were reported from the same study population (13 studies). Nineteen studies were used in the final analysis to estimate the pooled RRs for ever-smoking and the RRs for most cancer sites were estimated from a few studies including a large-scale cohort study [18-36]. When possible, the pooled RRs were separately estimated for cancer incidence and mortality.…”

Section: Methodsmentioning

confidence: 99%

Attributable fraction of tobacco smoking on cancer using population-based nationwide cancer incidence and mortality data in Korea

et al. 2014

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BackgroundSmoking is by far the most important cause of cancer that can be modified at the individual level. Cancer incidence and mortality rates in Korea are the highest among all Asian countries, and smoking prevalence in Korean men is one of the highest in developed countries. The purpose of the current study was to perform a systematic review and provide an evidence-based assessment of the burden of tobacco smoking-related cancers in the Korean population.MethodsSex- and cancer-specific population-attributable fractions (PAF) were estimated using the prevalence of ever-smoking and second-hand smoking in 1989 among Korean adults, respectively, and the relative risks were estimated from the meta-analysis of studies performed in the Korean population for ever-smoking and in the Asian population for passive smoking. National cancer incidence data from the Korea Central Cancer Registry and national cancer mortality data from Statistics Korea for the year 2009 were used to estimate the cancer cases and deaths attributable to tobacco smoking.ResultsTobacco smoking was responsible for 20,239 (20.9%) cancer incident cases and 14,377 (32.9%) cancer deaths among adult men and 1,930 (2.1%) cancer incident cases and 1,351 (5.2%) cancer deaths among adult women in 2009 in Korea. In men, 71% of lung cancer deaths, 55%–72% of upper aerodigestive tract (oral cavity, pharynx, esophagus and larynx) cancer deaths, 23% of liver, 32% of stomach, 27% of pancreas, 7% of kidney and 45% of bladder cancer deaths were attributable to tobacco smoking. In women the proportion of ever-smoking-attributable lung cancer was 8.1%, while that attributable to second-hand smoking among non-smoking women was 20.5%.ConclusionsApproximately one in three cancer deaths would be potentially preventable through appropriate control of tobacco smoking in Korean men at the population level and individual level. For Korean women, more lung cancer cases and deaths were attributable to second-hand than ever-smoking. Effective control programs against tobacco smoking should be further developed and implemented in Korea to reduce the smoking-related cancer burden.

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“…There was no randomized controlled trial (RCT) or cohort study included in our meta-analysis based on the criteria. All the ORs in the 15 studies were estimated based on the highest compared with the lowest dietary vitamin E intake or blood levels of vitamin E. Of those studies, 9 studies were conducted in America [ 6 , 10 , 13 – 16 , 18 , 22 , 23 ], 5 in Asian populations [ 11 – 12 , 17 , 19 , 21 ], 1 study in Europe [ 20 ]. All the studies were adjusted for a wide range of potential confounders, such as age, education, parity, and HPV infection status.…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin E supplementation on uterine cervical neoplasm: A meta-analysis of case-control studies

Zhou

et al. 2017

PLoS ONE

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Several epidemiological studies have suggested that vitamin E could reduce the risk of uterine cervical neoplasm. However, controversial data were presented by different reports. Hence, we conducted a meta-analysis to assess the relationship between vitamin E and the risk of cervical neoplasia. We performed a comprehensive search of the PubMed, Embase and Cochrane databases through December 31, 2016. Based on a fixed-effects or random-effects model, the odds ratio (OR) and 95% confidence intervals (CIs) were calculated to assess the combined risk. Subgroup analyses and meta-regression were done to assess the source of heterogeneity. Subgroup analyses were performed according to survey ways, types of cervical neoplasia, study populations. A protocol was registered with PROSPERO (No. CRD42016036672). In total, 15 case-control studies were included, involving 3741 cases and 6328 controls. Our study suggested that higher category of vitamin E could reduce the cervical neoplasia risk (OR = 0.58, 95% CIs = 0.47–0.72, I2 = 83%). In subgroup-analysis, both vitamin E intake and blood levels of vitamin E had a significant inverse association with the risk of cervical neoplasm. Additionally, we found the same relationship between vitamin E and cervical neoplasia among different populations and types of cervical neoplasia. Meta-regression showed that none of the including covariates were significantly related to the outcomes. No evidence of publication bias was observed. In conclusion, vitamin E intake and blood vitamin E levels were inversely associated with the risk of cervical neoplasia.

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Relationship of serum antioxidant micronutrients and sociodemographic factors to cervical neoplasia: a case-control study

Cited by 12 publications

References 30 publications

Zeaxanthin Induces Apoptosis in Human Uveal Melanoma Cells through Bcl-2 Family Proteins and Intrinsic Apoptosis Pathway

Zeaxanthin Induces Apoptosis in Human Uveal Melanoma Cells through Bcl-2 Family Proteins and Intrinsic Apoptosis Pathway

Attributable fraction of tobacco smoking on cancer using population-based nationwide cancer incidence and mortality data in Korea

Effect of vitamin E supplementation on uterine cervical neoplasm: A meta-analysis of case-control studies

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