Relationship of Serum Adiponectin Level to Adverse Cardiovascular Events in Patients Who Undergo Percutaneous Coronary Intervention

Shioji, Kosei; Moriwaki, Soji; Takeuchi, Yuzo; Uegaito, Takashi; Mutsuo, Satoru; Matsuda, Mitsuo

doi:10.1253/circj.71.675

Cited by 38 publications

(30 citation statements)

References 29 publications

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“…15 In another study, patients in the lowest quartile of residual adiponectin level had a higher risk of major adverse cardiac and cerebrovascular events. 18 These findings suggest that adiponectin plays a key role in atherosclerotic lesion development.…”

Section: Discussionmentioning

confidence: 95%

Effect of Adiponectin Overexpression on Stability of Preexisting Plaques by Inducing Prolyl-4-Hydroxylase Expression

Cai

Feng³

et al. 2010

Circ J

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Section: Discussionmentioning

confidence: 95%

Effect of Adiponectin Overexpression on Stability of Preexisting Plaques by Inducing Prolyl-4-Hydroxylase Expression

Cai

Feng³

et al. 2010

Circ J

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“…Increasing evidence suggested that adiponectin modulates cardiac remodeling in pathologic states 25) . In animal studies, pressure overload in adiponectin knock-out mice was associated with enhanced concentric cardiac hypertrophy and increased mortality, whereas adenovirus-mediated delivery of adiponectin attenuated cardiac hypertrophy in response to pressure overload in both adiponectin knock-out and wild-type mice 18) .…”

Section: Discussionmentioning

confidence: 99%

“…Adiponectin was also shown to protect against the development of systolic dysfunction after myocardial infarction through its ability to suppress cardiac hypertrophy and interstitial fibrosis, and to protect against myocyte and capillary loss 20) . Recently, baseline plasma adiponectin levels have been demonstrated to act as an independent predictor of left ventricular systolic dysfunction in patients referred for coronary angiography 21) , and predict clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) 22) . However, in patients with manifest CAD, adiponectin seems to play a paradoxical role and the results of recent studies are controversial.…”

Section: Introductionmentioning

confidence: 99%

Association of Adiponectin with Future Cardiovascular Events in Patients After Acute Myocardial Infarction

Huang

Chen

et al. 2010

JAT

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Aim:There is uncertainty about the association between circulating concentrations of adiponectin and coronary heart disease risk, particularly in patients after acute myocardial infarction (AMI). The goal of this study was to determine whether plasma adiponectin levels could predict future cardiovascular events in patients after AMI, and to elucidate the role of adiponectin in cardioprotection. Methods: A total of 102 patients with AMI were enrolled. Plasma adiponectin levels were examined from blood samples collected 18 months after AMI. All subjects were followed-up for 43 12 months. The primary endpoint was the combined occurrence of major adverse cardiovascular events (MACE), including rehospitalization due to unstable angina, nonfatal MI, revascularization with percutaneous coronary intervention or coronary artery bypass grafting, ischemic stroke, and cardiovascular death. Results: A total of 30 MACE occurred, including one case of cardiovascular death, five cases of nonfatal MI, and nine cases of ischemic stroke. Patients with MACE had lower plasma adiponectin levels (p 0.013). In addition, adiponectin was positively associated with changes in left ventricular ejection fraction (p 0.005). All patients were divided into a high-adiponectin group (≥ 6.46 g/mL) and a low-adiponectin group ( 6.46 g/mL). The incidence of MACE was significantly reduced in the high-adiponectin group (p 0.021). In multivariate Cox regression analysis that included adiponectin, classical risk factors, and medications, adiponectin was an independent predictor of MACE in patients after AMI (HR, 0.821; 95% CI, 0.691 to 0.974; p 0.024). Conclusions:The results indicate a potential association between plasma adiponectin levels and future cardiovascular events in patients after AMI. Moreover, plasma adiponectin concentrations appear to play a pivotal role in atherothrombosis and cardioprotection. J Atheroscler Thromb, 2010; 17:295-303.

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“…However, because the number of subjects requiring cardiovascular risk stratification is extremely large, all of the methods of morphological and functional assessment of vascular damage cannot be used in all of the subjects. Thus, the establishment of efficient strategies for risk stratification using new serological markers, 89,90 the morphological markers of vascular damage and vascular function tests (ie, selecting the best one, the best combination, or all), in addition to assessment of the risk factors for CVD, is needed.…”

Section: Perspectives and The Next Stepmentioning

confidence: 99%

Non-Invasive Vascular Function Tests:

Tomiyama

Yamashina

2010

Circ J

268

146

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp he clustering of conventional risk factors for cardiovascular disease (CVD) is associated with exaggerated vascular damage and poorer outcomes. 1 Therefore, clinical medicine and public health policies place significant emphasis on the modification of conventional risk factors and lifestyle behaviors to reduce the epidemic of CVD. 2 Although the population-attributable risk of major vascular risk factors is substantial, it is often difficult to distinguish those individuals with a moderate baseline risk who might benefit from aggressive risk reduction strategies. Furthermore, some studies have reported that the traditional cardiovascular risk factors account for "only 50%" of those who go on to develop coronary heart disease. 3 Therefore, additional tests to assist in the prediction of the cardiovascular risk in these individuals may be warranted. 4,5 Ultrasound examination of the carotid artery is increasingly being used as a surrogate marker of atherosclerosis and is a strong predictor of future vascular events. 6 However, evaluation of the regression of subclinical atherosclerosis by carotid arterial ultrasound examination following treatment of risk factors takes time (ie, more than 1 year is required in most cases to confirm such regression), 7 and therefore more sensitive markers to assess the effect of treatment of risk factors on vascular damage are proposed.Risk factors for CVD cause not only structural, but also functional vascular damage. Several non-invasive methods are currently used to assess functional vascular damage, including measurement of flow-mediated vasodilatation (FMD) of the brachial artery induced by reactive hyperemia, pulse wave velocity (PWV), augmentation index (AI), central blood pressure (BP), etc and these vascular function tests have attracted attention as new tools for determining CVD risk. [8][9][10][11][12][13][14][15] In this review, we describe the pathophysiology of vascular functions, the non-invasive methods of evaluating vascular functions and the clinical applicability of these tests for CVD risk stratification. Functions of ArteriesThe arterial wall has 3 layers (ie, the intima, including the endothelium, the media, and the adventitia) and each of these layers has a role in systemic circulation. Functions of the EndotheliumEndothelium regulates vascular tone, hemostasis and/or vascular permeability. 16 To exert these functions, endothelial cells biosynthesize several vasoactive substances, 17 and of these, nitric oxide (NO) in particular has a pivotal role in protecting against the initiation/progression of atherosclerosis via its vasodilatory activity and its inhibitory activity against vascular smooth muscle cell growth, nuclear transcription of cell adhesion molecules, platelet aggregation and The arterial wall has 3 layers (ie, the intima, including the endothelium, the media, and the adventitia); each of these layers has individual roles in systemic circulation. The ...

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Relationship of Serum Adiponectin Level to Adverse Cardiovascular Events in Patients Who Undergo Percutaneous Coronary Intervention

Cited by 38 publications

References 29 publications

Effect of Adiponectin Overexpression on Stability of Preexisting Plaques by Inducing Prolyl-4-Hydroxylase Expression

Effect of Adiponectin Overexpression on Stability of Preexisting Plaques by Inducing Prolyl-4-Hydroxylase Expression

Association of Adiponectin with Future Cardiovascular Events in Patients After Acute Myocardial Infarction

Non-Invasive Vascular Function Tests:

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