Relationship of serum 25-Hydroxyvitamin D (25[OH]D) levels and components of metabolic syndrome in prepubertal children

Kwon, Jung Hyun; Lee, Seung Eun; Lee, Hye Ah; Kim, Young Ju; Lee, Hwa Young; Gwak, Hye Sun; Park, Eun Ae; Cho, Su Jin; Oh, Se Young; Ha, Eun Hee; Park, Hyesook; Kim, Hae Soon

doi:10.1016/j.nut.2015.04.023

Cited by 11 publications

(16 citation statements)

References 22 publications

(32 reference statements)

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“…This study indicated that vitamin D deficient children had 0.1 kg/m 2 , 0.03 and 0.8 cm significantly greater yearly change in BMI, subscapular-to-triceps skinfold thickness ratio and waist circumference, respectively, than did vitamin D sufficient children suggesting vitamin D deficiency is associated with adiposity. A similar findings were reported in follow-up study of younger children in Korea where those children with the lowest quartile of 25(OH)D levels had the highest serum triacylglycerol levels that might be due to higher adiposity [ 49 ]. Similarly, a longitudinal study on older Norwegians adult population revealed that low serum 25(OH)D levels (<50 nmol/L) were associated with a significantly increased risk for incident obesity during a follow-up period [ 50 ].…”

Section: Discussionsupporting

confidence: 83%

Vitamin D Deficiency is Associated with Overweight and/or Obesity among Schoolchildren in Central Ethiopia: A Cross-Sectional Study

2016

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Childhood and adolescent obesity is an international public health problem leading to an increased risk of adulthood obesity, mortality and morbidity. Its prevalence is increasing in low-income populations, and we hypothesized it may be associated with vitamin D deficiency. Low vitamin D status is a worldwide public health issue including in Ethiopia; however, no one has examined overweight/obesity in Ethiopian schoolchildren with regard to vitamin D status. The Analyses of a data set from a school-based cross-sectional study conducted in Adama Town (n = 89) and in rural Adama Woreda (n = 85) was carried out to determine vitamin D deficiency and its association with overweight and/or obesity. Data on a total of 174 schoolchildren aged 11–18 years was used for these analyses. The overall prevalence of overweight and/or obesity was 10.3%, with 8.5% overweight and 2.3% obese; the prevalence of underweight was 19%. In the multivariable logistic regression model, vitamin D deficiency, being in the higher age group, female sex and urban residence of students, their mothers’ occupation of being employed and their households’ high and middle socioeconomic status were significantly associated with overweight and/or obesity. We concluded that vitamin D deficiency is an independent predictor significantly associated with overweight and/or obesity among schoolchildren from rural and urban settings in Ethiopia. The results imply the need for behavior change communications on the importance of exposure to sunlight to produce adequate vitamin D to curb this emerging health problem of overweight/obesity following economic growth and globalization in Ethiopia. As this study only highlighted the association, prospective studies and randomized controlled trials are required to establish causality.

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Section: Discussionsupporting

confidence: 83%

Vitamin D Deficiency is Associated with Overweight and/or Obesity among Schoolchildren in Central Ethiopia: A Cross-Sectional Study

2016

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“…Moreover, we found no significant association between serum Vitamin D concentration and FBS. The same results were also reported by some other studies,[2131] for instance Kelishadi et al reported no significant association between serum Vitamin D and FBS among Iranian children and adolescents. [17] However, some previous literatures declared the Vitamin D function in glucose hemostasis and insulin resistance and found an inverse relation between serum Vitamin D concentration and FBS among children and adolescents.…”

Section: Discussionsupporting

confidence: 88%

“…Our study did not find any association between serum 25(OH)D and TC, LDL, and HDL. The same results were confirmed by Kwon et al [21] However, some other studies conducted on older children and adolescents reported serum Vitamin D was related to all blood lipids. [1726] This controversy may be due to age differences of studies’ population.…”

Section: Discussionsupporting

confidence: 78%

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Association of vitamin D status and metabolic syndrome components in Iranian children

et al. 2019

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Background: Recently, it has been found that Vitamin D can affect cardiometabolic risk factors. However, these findings have not been confirmed in younger population. We aimed to assess the associations of serum 25-hydroxyvitamin D (25(OH)D) and metabolic syndrome (MetS) components in Iranian children. Methods: This cross-sectional study was conducted on 240 children aged 6–9 years old. Anthropometric indices (weight, height, waist circumference, and body fat), biochemical parameters (low-density lipoprotein, high-density lipoprotein, triglyceride [TG], fasting blood sugar, and serum 25(OH)D), systolic blood pressure (SBP) and diastolic blood pressure (DBP) blood pressure, and dietary intake and physical activity were measured. Multivariate linear regression analysis was used to assess the association of MetS components and serum 25(OH)D. Results: Mean age of children was 7.8 ± 1.06 year. Mean serum 25(OH)D concentration was 14.6 ± 10.64 ng/ml, and the prevalence of Vitamin D deficiency (serum 25(OH)D lower than 10 ng/ml) was 41.66%. Dietary intake of Vitamin D was 1.91 ± 1.8 mcg/day. Serum 25(OH)D was inversely associated with TG (β = −0.16; CI: −0.27, −0.04) after adjusting by age, gender, body mass index, physical activity, and some dietary components. Serum 25(OH)D was negatively associated with SBP (β = −0.02; CI: (−0.05, −0.004), and DBP (β = −0.02; CI: −0.05, −0.003); however, it was not significant anymore after adjustment for sodium, potassium, and fiber. Conclusions: Vitamin D deficiency is alarming among Iranian children. Among the components of MetS, lower serum Vitamin D concentration was only associated with TG that could contribute in onset and progression of cardiometabolic disorders later in life.

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“…Obesity plays a critical role in metabolic syndrome parameters. Associations between vitamin D level and components of metabolic syndrome were also found in Korean children and adolescents (50,51) , Iranian adolescents (52) and Chinese adolescents (53) . Here, we observed elevated risks of decreased HDL-C and impaired insulin resistance in US children and adolescents with vitamin D deficiency, especially in girls.…”

Section: Discussionmentioning

confidence: 74%

Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children

Zhi

Shu

et al. 2019

Public Health Nutr.

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Objective:To explore the relationships of serum 25-hydroxyvitamin D (25(OH)D) with obesity and metabolic parameters in US children.Design:Cross-sectional analysis. We evaluated the associations between serum 25(OH)D and multiple measurements of adiposity, serum lipid concentrations, fasting glucose and insulin resistance in children aged 6–18 years with adjustments for multiple covariates.Setting:The National Health and Nutrition Examination Survey, 2001–2006.Participants:A nationally representative sample of 6311 children and adolescents aged 6–18 years.Results:Among US children and adolescents, the prevalence of vitamin D deficiency has been especially high in older children, girls and the non-Hispanic Black population. Higher odds of obesity were found at a 25(OH)D concentration of <30 nmol/l (deficiency) than at >50 nmol/l under both criteria for obesity in children (OR = 3·27, Ptrend ≤ 0.001). Moreover, increased odds of having abnormal HDL-cholesterol (OR = 1·71, Ptrend ≤ 0.001) and impaired insulin resistance (OR = 4·15, Ptrend ≤ 0·001) were found for children deficient in 25(OH)D compared with those with normal 25(OH)D concentrations. When the children and adolescents were stratified by gender, we found stronger associations between serum 25(OH)D concentration and both HDL-cholesterol and insulin resistance in girls. No association of 25(OH)D with any other metabolic parameter was found.Conclusions:Our results suggest a potential harmful association between low serum 25(OH)D concentration and the risk of obesity among children. However, the underlying mechanisms require further investigation.

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Relationship of serum 25-Hydroxyvitamin D (25[OH]D) levels and components of metabolic syndrome in prepubertal children

Cited by 11 publications

References 22 publications

Vitamin D Deficiency is Associated with Overweight and/or Obesity among Schoolchildren in Central Ethiopia: A Cross-Sectional Study

Vitamin D Deficiency is Associated with Overweight and/or Obesity among Schoolchildren in Central Ethiopia: A Cross-Sectional Study

Association of vitamin D status and metabolic syndrome components in Iranian children

Serum 25-hydroxyvitamin D is associated with obesity and metabolic parameters in US children

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