Relationship of sarcopenia and body composition with osteoporosis

He, Hua; Liu, Y.; Tian, Qing; Papasian, Christopher J.; Hu, Tian; Deng, Hong−Wen

doi:10.1007/s00198-015-3241-8

Cited by 160 publications

(147 citation statements)

References 57 publications

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“…Therefore, the findings may be confounded by unmeasured or uncontrolled factors increasing the chance of Type I error. For example, we did not control for other 25(OH)D-related hormones (e.g., parathyroid hormone, PTH) and measures of bone health (e.g., bone mineral density), which have been implicated in the increased risk of sarcopenia (i.e., progressive loss of muscle mass and strength) [53], and higher GS and lean mass in older adults [54], respectively. On the other hand, adding more confounders to the fully adjusted model may have resulted in non-significant (bias) result and reduced power to detect significant associations, given the fact that each season-specific 25(OH)D quartile had, on average, 194 participants.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

et al. 2017

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Mixed reports exist about the role of 25-hydroxyvitamin D (25(OH)D) in muscle ageing and there are few prospective studies involving the very old (aged ≥ 85) who are at highest risk of low 25(OH)D, loss of muscle mass and strength, and physical performance decline. In the Newcastle 85+ Study (n = 845), we aimed to determine the association between 25(OH)D season-specific quartiles (hereafter SQ1–SQ4), grip strength (GS) and physical performance decline (Timed Up-and-Go Test, TUG) over 5 years using mixed models. In the time-only models with linear and quadratic slopes, SQ1 and SQ4 of 25(OH)D were associated with weaker GS initially in men (SQ1: β (SE) = −2.56 (0.96); SQ4: −2.16 (1.06)) and women (SQ1: −1.10 (0.52); SQ4: −1.28 (0.50)) (all p ≤ 0.04). In the fully adjusted models, only men in SQ1 had a significant annual decline in GS of 1.41 kg which accelerated over time (−0.40 (0.1)), (both p ≤ 0.003) compared with those in combined middle quartiles. Only women in SQ1 and SQ4 of 25(OH)D had worse TUG times initially, but the rate of TUG decline was not affected. Low baseline 25(OH)D may contribute to muscle strength decline in the very old and particularly in men.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

et al. 2017

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“…Physical performance is impaired because of weaker grip strength, slower gait speed, and poor mobility, which increase the risk of falling [50, 51]. Moreover, a low SMM is correlated with the metabolic syndrome [52], chronic kidney disease (CKD) [53], osteoporosis [54], and liver fibrosis [55]. Several endocrine diseases or CKD can accelerate the loss of muscle mass and strength, and lead to physical disability [56].…”

Section: Discussionmentioning

confidence: 99%

Medical costs of a low skeletal muscle mass are modulated by dietary diversity and physical activity in community-dwelling older Taiwanese: a longitudinal study

Wahlqvist

Huang

et al. 2017

Int J Behav Nutr Phys Act

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BackgroundAge-related loss of skeletal muscle mass (SMM) and function (sarcopenia) are associated with poor health outcomes and an economic burden on health care services. An appropriate diet and physical activity have been proposed for prevention and treatment of sarcopenia. Nevertheless, the effects on medical service utilization and costs remain unclear. This study determined the effects of SMM in conjunction with diet quality and physical activity on medical service utilization and expenditure in community-dwelling older Taiwanese.MethodsIn total, 1337 participants from the Elderly Nutrition and Health Survey in Taiwan (1999–2000) were enrolled. An SMM index [SMMI, calculated by dividing SMM (kg) by height (m2)] was used as the marker of sarcopenia. Participants with the lowest SMMI quartiles (<11.4 kg/m2 for men and 8.50 kg/m2 for women) comprised the high-risk group, and the remainder comprised the low-risk group. Dietary information (dietary diversity: low and high) and physical activity (low and moderate) were obtained at baseline. Annual medical service utilization and expenditure were calculated from National Health Insurance claims until December 31, 2006. Generalized linear models were used to determine the association between the SMMI and annual medical service utilization and costs in conjunction with dietary diversity or physical activity.ResultsAfter 8 follow-up years, regardless of gender, participants in the high-risk group reported significantly more hospitalization (days and expenditure) and total medical expenditure. Participants in the high-risk group who had low dietary diversity made fewer annual outpatient (14%), preventive care (19%), and dental (40%) visits, but exhibited longer hospitalization (102%) than did those who had a low SMMI and high dietary diversity. Similar patterns were observed in the corresponding medical expenditures. The findings were similar when considering physical activity. Being in the low-risk group in conjunction with having high dietary diversity or more physical activity was associated with the lowest annual adjusted mean hospitalization days with expenditure, and also total expenditure.ConclusionsA lower SMMI was associated with more hospitalization days and costs. However, high dietary diversity and more physical activity can attenuate the effects of lower SMMI on medical service utilization and expenditure.

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“…[12] Bone mineral density (BMD) has a positive correlation between muscle mass and muscle strength, and therefore, sarcopenia is related to osteoporosis. [34] In the process of aging of these muscles, the degree of intramuscular fatty degeneration increased, which is also associated with a decrease in mobility function. [5] Osteoporotic hip fracture is an important geriatric disease that threatens the life of the patient and impairs quality of life and is rapidly increasing with aging in elderly people over 65 years old.…”

Section: Introductionmentioning

confidence: 99%

Bone Mineral Density and Fatty Degeneration of Thigh Muscles Measured by Computed Tomography in Hip Fracture Patients

Hahn

Won

2016

J Bone Metab

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BackgroundRecently, as an independent fracture factor from Bone mineral density (BMD), muscle weakness due to the fatty degeneration of thigh muscles have been attracting attentions as causes of hip fracture. The purpose of this study is to investigate the correlation between the body composition and BMD and fatty degeneration of thigh muscles of the female patients over 65 years old with osteoporotic hip fracture.MethodsThis study was conducted with 178 female osteoporotic hip fracture patients. Total hip BMD was measured using dual energy X-ray absorptiometry. Cross-sectional area (CSA), cross-sectional muscle area (CSmA), muscle attenuation coefficient (MAC), and intramuscular adipose tissue (IMAT) of gluteus maximus, hip abductors, quadriceps and hamstring muscle were measured with computed tomography. Normalized IMAT (nIMAT) was calculated by dividing the fat area in the muscle into the size of each muscle. The correlation between each measurement is examined then the differences between the intertrochanteric fracture group and the femoral neck fracture group were analyzed.ResultsCSmA and MAC of quadriceps were the largest and nIMAT was the lowest. CSA and CSmA of the four muscles showed a statistically significant positive correlation with weight, height, body mass index (BMI), and BMD. MAC of 2 gluteal muscles was positively correlated with weight, BMI and BMD. nIMAT of all four muscles was positively correlation with weight and BMI but nIMAT of 2 mid-thigh muscles was positively correlation with BMD.ConclusionsMuscle size and fatty degeneration in the thigh muscles were most positively correlated with the body weight. BMD was positively correlation with CSA and CSmA of all thigh muscles, and MAC of 2 gluteal muscles and fatty degeneration of 2 mid-thigh muscles. There was no statistically significant difference in the size of the femoral muscle and the degree of fatty degeneration between the two fracture groups.

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Relationship of sarcopenia and body composition with osteoporosis

Abstract: High lean mass and muscle strength were positively associated with BMDs. Sarcopenia is associated with low BMD and osteoporosis.

Cited by 160 publications

References 57 publications

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study

Medical costs of a low skeletal muscle mass are modulated by dietary diversity and physical activity in community-dwelling older Taiwanese: a longitudinal study

Bone Mineral Density and Fatty Degeneration of Thigh Muscles Measured by Computed Tomography in Hip Fracture Patients

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