Relationship of pulse pressure index and carotid intima-media thickness in hypertensive adults

Cai, Anping; Mo, Yujing; Zhang, Ying; Li, Jie; Chen, Jiyan; Zhou, Yingling; Chen, Ruyuan; Wei, Ruibin; Huang, Yu-Qing; Tang, Songtao; Feng, Yingqing

doi:10.3109/10641963.2014.954713

Cited by 22 publications

(24 citation statements)

References 12 publications

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“…Prior research already demonstrated that hypertensive patients with higher PPI had a more reduced renal function[ 7 ]. Furthermore, PPI was also found to be useful in early screening of carotid atherosclerosis among these patients[ 8 ]. Despite this well-understood importance of PPI as a prognostic/screening indicator, in China, there remained a dearth of information regarding the burden of PPI among patients having hypertension, especially in Kazakh-Chinese community.…”

Section: Introductionmentioning

confidence: 99%

Association between Anthropometric Measures and Indicators for Hypertension Control among Kazakh-Chinese Hypertension Patients in Xinjiang, China: Results from a Cross-sectional Study

et al. 2017

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BackgroundAmong Kazakh-Chinese population in Xinjiang province of China, prevalence of obesity and hypertension were 40.1% and 50.3% respectively, the highest across all ethnic groups residing in this pastureland. Despite this, there remained a dearth of information regarding the association between the anthropometric measures [body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), Waist-to-height ratio (WHtR) etc.] and indicators for hypertension control [achieved levels of systolic and diastolic blood pressures (SBP and DBP), pulse pressure index (PPI), ankle-brachial index (ABI) etc.] among them.MethodA cross-sectional study was conducted in Xinjiang to determine the distribution and inter-relationships of the anthropometric measures and indicators for achieved BP control as well as their predictors among hypertension patients of Kazakh-Chinese ethnicity. Out of 550 randomly selected patients, 516 completed the interview, anthropometry and BP assessments.ResultsIn the sample population, average SBP, DBP and PP were 156.26±24.40mmHg, 87.55±14.73mmHg and 68.71±19.39mmHg respectively. Bivariate analysis identified age, gender, education, duration of hypertension, WC and BMI being factors influencing the achieved levels of BP. Adjusted multiple linear regression models elicited positive associations of age (βa = 0.152, p = 0.001) and duration of hypertension (βa = 0.132, p = 0.003) with achieved level of SBP as well as BMI (βa = 0.135, p = 0.002) with DBP. Age (βa = 0.207, p<0.001) and WHtR (βa = 0.304, p = 0.005) were positively and WC (βa = -0.406, p<0.001) was negatively associated with PPI. Increasing age (βa = -0.125, p = 0.005), female gender (βa = -0.122, p = 0.005) and 5years’ duration of hypertension (βa = -0.091, p<0.039) were negatively associated with ABI. After adjustment for socio-demographic variables, hypertensive patients with (reference = without) abdominal obesity had 93% (p = 0.013) higher odds of missing the target BP control.ConclusionAnthropometric measures and indicators for blood pressure control among Kazakh-Chinese patients were far beyond normal. Several anthropometric measures appeared useful for monitoring BP. Using them, regular screening and consequent targeted intervention were required urgently to control hypertension among Kazakh-Chinese.

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Section: Introductionmentioning

confidence: 99%

Association between Anthropometric Measures and Indicators for Hypertension Control among Kazakh-Chinese Hypertension Patients in Xinjiang, China: Results from a Cross-sectional Study

et al. 2017

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“…Although the relationship between blood pressure and CIMT has been demonstrated in many studies, few studies have explored the relationship between PP and CIMT, especially in a low socioeconomic status population. PP, a significant independent risk factor for cardiovascular mortality (21), has been shown in some experimental and clinical studies to modulate CIMT (13,22,23). After a 4-year follow-up, the Etude du Vieillissement Artériel study demonstrated that elevated PP levels were associated with CIMT progression, and increased CIMT was associated with PP widening (12).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, studies have shown a direct association between PP and CIMT (11,12). A previous study of adults with hypertension demonstrated that diastolic blood pressure (DBP) was lower in the group with increased CIMTs than it was in the group with normal CIMTs; PPs and the PP index [(SBP-DBP)/DBP] were significantly higher in the group with increased CIMTs (13).…”

Section: Introductionmentioning

confidence: 99%

Association Between Pulse Pressure and Carotid Intima-Media Thickness Among Low-Income Adults Aged 45 Years and Older: A Population-Based Cross-Sectional Study in Rural China

Liu

Lin

Guo

et al. 2020

Front. Cardiovasc. Med.

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Worldwide, the stroke burden remains severe, especially for people in low socioeconomic groups. Atherosclerosis is a leading cause of stroke that is attracting increasingly greater attention. Blood pressure, including pulse pressure (PP) and systolic (SBP) and diastolic (DBP) blood pressures, is a traditional risk factor for atherosclerosis; its association with carotid intima-media thickness (CIMT) has also been widely studied. However, published studies have not reported on the relationship between PP and CIMT in low-income adults. Thus, this study investigated the relationship between PP and CIMT in a low-income population, in China. A total of 3,789 people, aged ≥45 years and without histories of stroke or cardiovascular disease, were recruited into this study. B-mode ultrasonography was performed to determine CIMTs. Demographic characteristics, physical examination data, previous medical histories, and laboratory test results were collected for each study participant. Multiple linear regression models were used to analyze the association between CIMT and PP. The mean CIMT was 567.1 μm (males, 583.5 μm; females, 555.7 μm). The SBP, DBP, PP, and mean arterial pressure (MAP) values were all positively correlated with CIMT, in the univariate analysis; PP and MAP showed the strongest correlations. In addition, in three multiple linear regression models, PP was shown to be significantly associated with CIMT; each 1-mm Hg increase in PP resulted in a CIMT increase of ≥0.41 μm (all P < 0.001). Our results demonstrated that, when compared with SBP, DBP, and MAP, PP may be the best predictor of CIMT. Thus, controlling blood pressure, especially PP levels, is vital to decreasing the prevalence of atherosclerosis, especially in this low socioeconomic status population in China.

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“…In our study, 12 sessions of CR did not affect the PPI. Cai et al in 2015 showed that PPI have a significant relationship with intima-media carotid thickness in adults and thus it is a valuable parameter for primary screening of patients with atherosclerosis risk [16]. We can conclude that PPI is associated with vascular atherosclerosis, as well as cardiac output; as a result it's expected that PPI cannot completely show the effect of CR on cardiac function alone; and more accurate indicators of cardiac output like angiographic calculations or cardiac output measurements by the Fick method that effects on cardiac function are needed, but because of their risks and invasive nature of the procedures, they are not routinely performed for this purpose.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Pulse Pressure Index at the Peak of Exercise Before and After Cardiac Rehabilitation

Yazdi

Kazemi

Esna-Ashari

et al. 2017

ijcp

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Introduction: As a new supplementary therapeutic option, cardiac rehabilitation (CR) is getting more attention every day. Several studies have proved its positive impact on qualitative criteria; but few studies have been done on quantitative criteria. The purpose of the present study is to evaluate the impact of CR on non-invasive measurement of maximum cardiac output by Pulse Pressure index (PPI) at the peak of exercise. Methods: This is a non-randomized prospective cohort study conducted in Hamadan, Iran in 2015. One hundred eligible patients who had undergone coronary artery bypass surgery participated in our study, after obtaining cardiologist permission and informed consent. The PPI was measured at the peak of exercise before and after standard CR program. Results: Mean PPI was not significantly different before and after CR. PPI was significantly increased in patients younger than 60 years old (P = 0.022). In contrast to hypertensive patients, PPI increased significantly after CR in non-hypertensive patients (P = 0.002). PPI was significantly increased in non-diabetic patients after CR (P = 0.046), but not in diabetic individuals. Other variables did not show any statistically significant effect on PPI in response to CR. Conclusions: Findings from our study revealed that PPI is associated with vascular atherosclerosis, as well as cardiac output; Positive effects of CR diminish in older, diabetic and hypertensive patients with more progressive atherosclerosis.

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Relationship of pulse pressure index and carotid intima-media thickness in hypertensive adults

Abstract: PPI is a valuable parameter for the preliminary screening of hypertensive patients who have an increased risk of atherosclerosis.

Cited by 22 publications

References 12 publications

Association between Anthropometric Measures and Indicators for Hypertension Control among Kazakh-Chinese Hypertension Patients in Xinjiang, China: Results from a Cross-sectional Study

Association between Anthropometric Measures and Indicators for Hypertension Control among Kazakh-Chinese Hypertension Patients in Xinjiang, China: Results from a Cross-sectional Study

Association Between Pulse Pressure and Carotid Intima-Media Thickness Among Low-Income Adults Aged 45 Years and Older: A Population-Based Cross-Sectional Study in Rural China

Evaluation of the Pulse Pressure Index at the Peak of Exercise Before and After Cardiac Rehabilitation

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