Relationship of Prostate -Specific Antigen to Age and Testosterone in Men With Type 2 Diabetes Mellitus

Dhindsa, Sandeep; Upadhyay, Manish; Viswanathan, Prabhakar; Howard, Susan J.; Chaudhuri, Ajay; Dandona, Paresh

doi:10.4158/ep.14.8.1000

Cited by 16 publications

(13 citation statements)

References 20 publications

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“…The result confirmed the previous study by Dhindsa et al. [48], which reported that serum PSA concentrations are lower in type 2 diabetic men with hypogonadism than in eugonadal men with type 2 diabetes. In a more recent study, Rastrelli et al.…”

Section: Discussionsupporting

confidence: 92%

“…The present study recognized an inverse association between serum PSA level and the risk of testosterone deficiency in type 2 diabetic men; in other words, there was a positive correlation between serum PSA and testosterone level. The result confirmed the previous study by Dhindsa et al [48], which reported that serum PSA concentrations are lower in type 2 diabetic men with hypogonadism than in eugonadal men with type 2 diabetes. In a more recent study, Rastrelli et al [45] further reported that PSA can be a marker for serum testosterone level.…”

Section: Discussionsupporting

confidence: 92%

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The Prevalence and the Risk Factors of Testosterone Deficiency in Newly Diagnosed and Previously Known Type 2 Diabetic Men

Jaw

et al. 2015

The Journal of Sexual Medicine

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Introduction While the epidemiology of testosterone deficiency has been well described in men with previously known type 2 diabetes mellitus (T2DM), it was less reported in those with untreated, newly diagnosed T2DM. Aim The aim of this study was to investigate the prevalence and the risk factors of testosterone deficiency of men with newly diagnosed T2DM. Methods The cross-sectional study included 105 men (mean age: 61.2 ± 6.8 years) with previously known T2DM and another 81 (57.8 ± 8.8 years) with newly diagnosed T2DM. All received health checkup and sex hormone measurement at our institute in 2009. Main Outcome Measures We calculated the prevalence and explored the risk factors of low total (<300 ng/dL) and free (<6 ng/dL) testosterone in men with newly diagnosed and previously known T2DM. Results Men with previously known T2DM were older and had higher diastolic pressure and greater fasting glucose. There was no significant difference in total (358.0 [155.0] ng/dL vs. 363.0 [154.0] ng/dL, P = 0.68) and free (7.2 [2.5] ng/dL vs. 7.4 [2.4] ng/dL, P = 0.84) testosterone and sex-hormone binding globulin (SHBG) (27.3 [22.3] nmol/L vs. 28.7 [14.9] nmol/L, P = 0.46). The prevalence of low total and free testosterone was 28.4% and 21.0%, respectively, in men with newly diagnosed T2DM, and was 26.7% and 19.0% in those with previously known T2DM. In men with previously known T2DM, better glycemic control (HbA1c <7%) was associated with a higher level of total testosterone and a lower risk of low total testosterone. Men with newly diagnosed and previously known T2DM shared similar risk factors of low total testosterone, including high HbA1c (≥7%), low SHBG (<20 nmol/L), obesity, hyperuricemia, hypertriglycemia, and metabolic syndrome. Elevated prostate-specific antigen was a protective factor of low total testosterone. However, none of these factors was associated with low free testosterone. Conclusions The prevalence and the risk factors of testosterone deficiency are similar between newly diagnosed and previously known type 2 diabetic men.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

The Prevalence and the Risk Factors of Testosterone Deficiency in Newly Diagnosed and Previously Known Type 2 Diabetic Men

Jaw

et al. 2015

The Journal of Sexual Medicine

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“…showed that insulin resistance diminishes after 6 months of testosterone treatment in 24 patients with idiopathic hypogonadotropic hypogonadism. In a cross‐sectional study on 280 patients by Dhindsa et al., it was shown that the serum PSA level was lower in type 2 diabetic men with hypogonadism than in eugonadal men with type 2 DM, and the free testosterone level was a predictor for PSA concentration upon regression analysis.…”

Section: Discussionmentioning

confidence: 99%

Risk of new‐onset diabetes after androgen deprivation therapy for prostate cancer in the Asian population

Teoh

Chiu

Chan

et al. 2014

Journal of Diabetes

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“…, 2006), osteopenia (Dhindsa et al. , 2007), low prostatic specific antigen (PSA) (Dhindsa et al. , 2008) and markedly elevated C‐reactive protein concentrations (Bhatia et al.…”

Section: Discussionmentioning

confidence: 99%

Type 2 diabetes mellitus and testosterone: a meta-analysis study

Corona

Monami

Rastrelli

et al. 2010

International Journal of Andrology

327

273

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Several studies suggest that type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. Despite the well-known link, the role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. The aim of the present study was to analyse systematically the relationship between androgen levels and T2DM by reviewing and meta-analysing available prospective and cross-sectional studies. In addition, a specific meta-analysis on the metabolic effects of TRT in available randomized clinical trials (RCTs) was performed. An extensive Medline search was performed including the following words: 'testosterone', 'type 2 diabetes mellitus' and 'males'. Of 742 retrieved articles, 37 were included in the study. In particular 28, 5 and 3 were cross-sectional, longitudinal and interventional studies, respectively. A further unpublished RCT was retrieved from http://www.clinicaltrials.gov. T2DM patients showed significantly lower testosterone plasma levels in comparison with non-diabetic individuals. Similar results were obtained when T2DM subjects with and without erectile dysfunction were analysed separately. Meta-regression analysis demonstrated that ageing reduced, while obesity increased, these differences. However, in a multiple regression model, after adjusting for age and body mass index (BMI), T2DM was still associated with lower total testosterone (TT) levels (adjusted r = -0.568; p < 0.0001). Analysis of longitudinal studies demonstrated that baseline TT was significantly lower among patients with incident diabetes in comparison with controls (HR = -2.08[-3.57;-0.59]; p < 0.001). Combining the results of RCTs, TRT was associated with a significant reduction in fasting plasma glucose, HbA1c, fat mass and triglycerides. Conversely, no significant difference was observed for total and high-density lipoprotein cholesterol, blood pressure and BMI. The meta-analysis of the available cross-sectional data suggests that T2DM can be considered independently associated with male hypogonadism. Although only few RCTs have been reported, TRT seems to improve glycometabolic control as well as fat mass in T2DM subjects.

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Relationship of Prostate -Specific Antigen to Age and Testosterone in Men With Type 2 Diabetes Mellitus

Cited by 16 publications

References 20 publications

The Prevalence and the Risk Factors of Testosterone Deficiency in Newly Diagnosed and Previously Known Type 2 Diabetic Men

The Prevalence and the Risk Factors of Testosterone Deficiency in Newly Diagnosed and Previously Known Type 2 Diabetic Men

Risk of new‐onset diabetes after androgen deprivation therapy for prostate cancer in the Asian population

Type 2 diabetes mellitus and testosterone: a meta-analysis study

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