Relationship of Prostate Specific Antigen and Digital Rectal Examination in the Prediction of Prostate Cancer

Timilsina, Bhusan Raj; Devkota, Gaurav; Giri, Shweta; Pradhan, Snehasis; Kc, Sudeep Raj

doi:10.3126/jcmsn.v16i2.29122

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…The required sample size was calculated using G*Power software (20), based on the expected correlation of DRE and PSA values with prostate biopsy PH findings. Taking into account recently published studies (21) in this field in Europe and the world, 151 subjects were needed to conduct the research in terms of the minimum number of subjects for this cross-sectional study.…”

Section: Sample Size Calculationmentioning

confidence: 99%

Prognostic Value of Prostata Specific Antigen and Digital Rectal Examination at Prostate Biopsy

Milutinovic,

Djordjevic,

Todorovic

et al. 2024

Experimental and Applied Biomedical Research (EABR)

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Prostate cancer is a worldwide health concern with an increasing global incidence. In the Republic of Serbia, it is the third most commonly diagnosed cancer in men. The research aims to determine the influence of PSA value and digital rectal examination on the pathohistological findings of prostate biopsy in men in Central Serbia. The study was designed as a retrospective, cross-sectional analytical study conducted in the period from December 2021 to December 2022 after receiving the confirmation of the Ethics Committee of the University of Applied Sciences Kragujevac. Among 151 respondents aged 49 to 88 who underwent consecutive biopsies during the study period, prostate cancer was detected in 65 (42%). Out of 65 positive biopsies, 33 subjects had a Gleason score of up to 7, while 32 subjects had a Gleason score over 7. Prostate biopsies significantly correlated with PSA levels (p=0.02), while DRE and prostate volume did not show statistical significance on the prostate biopsy result. PSA level testing leads to early detection of prostate disease in the elderly. PSA value was the only clinical variable associated with an increased rate of prostate cancer in men ≥ 70 and older (p=0.02). DRE, PSA, and prostate volume are important parameters associated with an increase in prostate cancer detection rate in men over 70 years of age.

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Section: Sample Size Calculationmentioning

confidence: 99%