Relationship of PPARgamma2 Polymorphism with Obesity and Metabolic Syndrome in Postmenopausal Polish Women

Abstract

The Pro12Ala PPARgamma polymorphism does not seem to be associated with BMI or metabolic syndrome parameters in postmenopausal Polish women, although the X/Ala genotype seems to predispose to a less favorable lipid profile in this population.

Relationships between <em>FTO</em> rs9939609, <em>MC4R</em> rs17782313, and <em>PPAR&gamma;</em> rs1801282 polymorphisms and the occurrence of selected metabolic and hormonal disorders in middle-aged and elderly men &ndash; a preliminary study

“…However, those studies were conducted among younger men, so it can be assumed that environmental influences were lower. As in this study, Milewicz et al56 did not observe any association between the studied PPARγ rs1801282 polymorphism and MetS and metabolic parameters in postmenopausal women from Poland. Also studies conducted on an ethnically diverse group of people (Caucasian, South Asian, and African American) did not show any association between the PPARγ rs1801282 polymorphism and MetS 32.…”

FTO T/A and Peroxisome Proliferator-Activated Receptor-γ Pro12Ala Polymorphisms but Not ApoA1 −75 Are Associated with Better Response to Lifestyle Intervention in Brazilians at High Cardiometabolic Risk

“…[46][47][48] In our sample of Brazilian individuals, there was no effect of the intervention and no effect of interaction between the intervention and PPARg Pro12Ala for body adiposity.…”

Obesity and Pro12Ala Polymorphism of Peroxisome Proliferator-Activated Receptor-Gamma Gene in Healthy Adults: A Systematic Review and Meta-Analysis

“…Forty studies were on Caucasians [5,8,10,12,25,26,27,28,29,32,33,34,35,36,37,38,39,41,42,43,45,46,47,48,52,53,54,57,60,61,62,63,64,65,66,67,68,69,70], 10 studies were on Asian [31,40,49,50,55,56,58,59,71,72] and 6 studies were on mixed populations [7,30,37,73,74,75]. Between 56 studies, 19 studies provided data on male [10,12,29,33,35,37,40,42,43,47,50,57,60,61,62,65,66,69,71] and 22 studies on female members [10,12,29,32,37,41,42,50,53,54,55,59,60,61,62,64,66,68,69…”

“…Nine cohort studies [12,25,26,27,28,29,30,31,32], 7 population case-control studies [33,34,35,36,37,38,39], 31 cross-sectional studies [5,7,10,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67], and 9 interventional studies [8,68,69,70,71,72,73,74,75] were included in the meta-analysis of the association between PPARγ Pro12Ala polymorphism and obesity. The characteristics and results of the studies are summarized in table 1.…”