Relationship of plasma brain-type natriuretic peptide levels to left ventricular longitudinal function in patients with congestive heart failure assessed by strain Doppler imaging

Yoneyama, Ayako; Koyama, Jun; Tomita, Takeshi; Kumazaki, Setsuo; Tsutsui, Hiroshi; Watanabe, Noboru; Katoh, Osamu; Ikeda, Uichi

doi:10.1016/j.ijcard.2007.07.171

Cited by 32 publications

(27 citation statements)

References 40 publications

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“…The slope of the regression line relating VCO 2 and Ve generates the Ve/VCO 2 slope, which therefore represents the ventilatory response to exercise. The steepness of the slope is positively related to symptom severity and a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…1) In recent years, efforts were made to develop potential biomarkers to identify populations with high risk of HF-related events. Plasma B-type natriuretic protein (BNP), released by an increase in left ventricular wall stress, was validated in conjunction with other clinical information for diagnosing systolic and diastolic HF 2) and for estimating the prognosis of HF. On the other hand, a variety of parameters from the cardiopulmonary exercise test (CPET) were also shown to be useful predictors of HF-related events, such as the oxygen uptake efficiency slope (OUES), 3,4) the minute ventilation/carbonic dioxide production (Ve/VCO 2 ) slope, 5) and peak oxygen uptake (VO 2 ).…”

mentioning

confidence: 99%

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Non-Invasive Cardiac Index Monitoring During Cardiopulmonary Functional Testing Provides Additional Prognostic Value in Patients After Acute Heart Failure

Lee

Chen

et al. 2012

Int. Heart J.

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SummaryThe prognostic value of parameters derived from a cardiopulmonary exercise test (CPET) is well established in patients stabilized after acute heart failure (HF). Under multidisciplinary disease management, this study sought to test whether noninvasive cardiac output (CO) monitoring (NICOM) during the CPET provides additional prognostic value. In total, 131 patients stabilized after acute HF agreed to undergo the CPET with NICOM. Outcome follow-up focused on composite events of death and HF-related rehospitalization. Patients with a peak cardiac index (CI) of ≤ 4.5 L/minute/ m 2 (n = 32), compared to those with a peak CI of > 4.5 L/minute/m 2 (n = 99), had higher incidences of diabetes mellitus (DM) and hypertension, but had lower hemoglobin levels, estimated glomerular filtration rates (eGFR), oxygen uptake efficiency slope (OUES), and peak oxygen uptake (VO 2 ). During the 1.2 ± 0.7 years of follow-up, there were 8 (6.1%) deaths, and 16 (12.2%) HF-related rehospitalizations. In a Cox univariable analysis, a lower event-free survival was associated with a history of DM, a higher Ve/VCO 2 slope, lower peak VCO 2 and eGFR, and a peak CI of ≤ 4.5 L/minute/ m 2 (P < 0.05). The Cox multivariable analysis showed that the Ve/VCO 2 slope (hazard ratio (HR) = 1.08, 95% confidence interval (CI): 1.01~1.16, P = 0.02) and peak CI of ≤ 4.5 L/minute/m 2 (HR = 3.26, 95% CI: 1.18~9.01, P = 0.02) were significant independent predictors. In conclusion, NICOM during the CPET was demonstrated to provide prognostic information in addition to traditional risk factors, biomarkers, and other well-established CPET parameters. (Int Heart J 2012; 53: 364-369)

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Non-Invasive Cardiac Index Monitoring During Cardiopulmonary Functional Testing Provides Additional Prognostic Value in Patients After Acute Heart Failure

Lee

Chen

et al. 2012

Int. Heart J.

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“…In a study on 137 consecutive patients with suspected congestive heart failure of different etiologies it was also shown that mean longitudinal LV strain is closely related to plasma brain-type natriuretic peptide (BNP) levels, in patients with both systolic and diastolic heart failure [42].…”

Section: Clinical Applications and Future Directions Of Echocardiogramentioning

confidence: 99%

Echocardiographic strain and strain rate imaging — Clinical applications

Dandel¹,

Hetzer²

2009

International Journal of Cardiology

251

211

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“…Clinical studies have reported reduced LV systolic tissue velocity in heart failure patients and have demonstrated that this parameter can be useful in diagnosis (51,54). Comparable observations have been made in animal models of heart failure.…”

Section: Slower Cardiomyocyte Contractions In Chfmentioning

confidence: 99%

Slowing of cardiomyocyte Ca²⁺ release and contraction during heart failure progression in postinfarction mice

Mørk

Sjaastad²,

Sejersted³

et al. 2009

American Journal of Physiology-Heart and Circulatory Physiology

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Deterioration of cardiac contractility during congestive heart failure (CHF) is believed to involve decreased function of individual cardiomyocytes and may include reductions in contraction magnitude and/or kinetics. We examined the progression of in vivo and in vitro alterations in contractile function in CHF mice and investigated underlying alterations in Ca2+ homeostasis. Following induction of myocardial infarction (MI), mice with CHF were examined at early (1 wk post-MI) and chronic (10 wk post-MI) stages of disease development. Sham-operated mice served as controls. Global and local left ventricle function were assessed by echocardiography in sedated animals (∼2% isoflurane). Excitation-contraction coupling was examined in cardiomyocytes isolated from the viable septum. CHF progression between 1 and 10 wk post-MI resulted in increased mortality, development of hypertrophy, and deterioration of global left ventricular function. Local function in the noninfarcted myocardium also declined, as posterior wall shortening velocity was reduced in chronic CHF (1.2 ± 0.1 vs. 1.9 ± 0.2 cm/s in sham). Parallel alterations occurred in isolated cardiomyocytes since contraction and Ca2+ transient time to peak values were prolonged in chronic CHF (115 ± 6 and 158 ± 11% sham values, respectively). Surprisingly, contraction and Ca2+ transient magnitudes in CHF were larger than sham values at both time points, resulting from increased sarcoplasmic reticulum Ca2+ content and greater Ca2+ influx via L-type channels. We conclude that, in mice with CHF following myocardial infarction, declining myocardial function involves slowing of cardiomyocyte contraction without reduction in contraction magnitude. Corresponding alterations in Ca2+ transients suggest that slowing of Ca2+ release is a critical mediator of CHF progression.

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Relationship of plasma brain-type natriuretic peptide levels to left ventricular longitudinal function in patients with congestive heart failure assessed by strain Doppler imaging

Cited by 32 publications

References 40 publications

Non-Invasive Cardiac Index Monitoring During Cardiopulmonary Functional Testing Provides Additional Prognostic Value in Patients After Acute Heart Failure

Non-Invasive Cardiac Index Monitoring During Cardiopulmonary Functional Testing Provides Additional Prognostic Value in Patients After Acute Heart Failure

Echocardiographic strain and strain rate imaging — Clinical applications

Slowing of cardiomyocyte Ca²⁺ release and contraction during heart failure progression in postinfarction mice

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Relationship of plasma brain-type natriuretic peptide levels to left ventricular longitudinal function in patients with congestive heart failure assessed by strain Doppler imaging

Cited by 32 publications

References 40 publications

Non-Invasive Cardiac Index Monitoring During Cardiopulmonary Functional Testing Provides Additional Prognostic Value in Patients After Acute Heart Failure

Non-Invasive Cardiac Index Monitoring During Cardiopulmonary Functional Testing Provides Additional Prognostic Value in Patients After Acute Heart Failure

Echocardiographic strain and strain rate imaging — Clinical applications

Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice

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Slowing of cardiomyocyte Ca²⁺ release and contraction during heart failure progression in postinfarction mice