Relationship of Phenothiazine Intake and Psychiatric Diagnosis to Glucose Level and Tolerance

Efron, Herman Y.; Balter, Abraham M.

doi:10.1097/00005053-196606000-00007

Cited by 9 publications

(9 citation statements)

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“…Typical antipsychotics are not reported to cause an increased risk for T2D (Efron and Balter, 1966; Liebzeit et al, 2001), but it was not studied whether typical antipsychotics can decrease T2D risk associated with SCZ.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast to the hyperprolactinemia caused by typical antipsychotics, atypical antipsychotics do not appear to cause an elevation in prolactin levels. Furthermore, atypical antipsychotics clozapine, olanzapine, and quetiapine, but not risperidone in schizophrenic patients increase the risk and incidence of new‐onset T2D compared to typical antipsychotics (Efron and Balter, 1966; Liebzeit et al, 2001; Dwyer and Donohoe, 2003; Molitch, 2005). Risperidone is the exception as it causes elevation in prolactin similar to that caused by typical antipsychotics (Dwyer and Donohoe, 2003).…”

Section: Resultsmentioning

confidence: 99%

“…SCZ is associated with increased risk for T2D in patients without antipsychotic drug use. The typical antipsychotics appear to protect from the SCZ‐associated increased risk for T2D (Efron and Balter, 1966; Liebzeit et al, 2001), while atypical antipsychotics increase the risk for T2D (Sernyak et al, 2002; Dwyer and Donohoe, 2003).…”

mentioning

confidence: 99%

“…Clozapine, olanzapine, quetiapine, and risperidone are among the most commonly used atypical antipsychotics. Most studies have focused on these atypical antipsychotics in order to gain a better understanding of the mechanism underlying the induction of T2D (Efron and Balter, 1966; Liebzeit et al, 2001; Sernyak et al, 2002; Dwyer and Donohoe, 2003).…”

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confidence: 99%

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Potential role of prolactin in antipsychotic‐mediated association of schizophrenia and type 2 diabetes

Oberweis

Gragnoli

2012

Journal Cellular Physiology

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It remains unclear why atypical antipsychotics confer a risk for hyperglycemia compared to typical antipsychotics. Atypical antipsychotics antagonize dopamine receptors-2 (D(2)) and serotonin (5-HT) receptors-2, while typical antipsychotics antagonize only D(2) receptors. We aimed at elucidating the mechanistic differences between the role of typical and atypical antipsychotics on prolactin levels and glucose regulation. A Medline search was conducted during 2010 using the search terms type 2 diabetes (T2D), typical/atypical antipsychotics, schizophrenia, prolactin, and serotonin. We discuss the effect of typical and atypical antipsychotics on prolactin levels and glucose regulation. Given that prolactin is under negative control by dopamine and positive control by serotonin, typical antipsychotics induce elevations in prolactin, while atypical antipsychotics do not. Research studies show protective effects of prolactin on T2D. We hypothesize that the difference in induction of T2D between typical and atypical antipsychotics is due to the antipsychotic receptor binding mediated effect in changes in prolactin levels.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Potential role of prolactin in antipsychotic‐mediated association of schizophrenia and type 2 diabetes

Oberweis

Gragnoli

2012

Journal Cellular Physiology

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“…The association of diabetes mellitus (DM) with conventional antipsychotic agents has been controversial (Efron and Balter 1966;Mukherjee et al 1996;ThonnardNeumann 1968;Tollefson and Lesar 1983). However, the data that link the atypical antipsychotic agents to hyperglycemia, hyperlipidemia, and DM have been accumulating.…”

Section: Introductionmentioning

confidence: 99%

Can Diabetes Mellitus Be Induced by Medication?

Saito

Kafantaris²

2002

Journal of Child and Adolescent Psychopharmacology

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The possible relation between diabetes mellitus and the use of psychotropic medications in adult psychiatric patients has been discussed in the literature. In child and adolescent psychiatry, however, there have been only two previous case reports of an adolescent who developed diabetes mellitus while receiving psychotropic medications. We present three adolescents who developed diabetes mellitus after combined treatment with divalproex sodium and atypical antipsychotics. All were African American, obese, and had a family history of diabetes mellitus. We discuss each case and examine the possibility of psychotropic medication-induced diabetes mellitus in adolescents.

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Phase 1 treatment for the chronic and previously treated anorexia. Bulimia nervosa patient

Holmgren

Sohlberg

Berg

et al. 1984

Int. J. Eat. Disord.

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Treatment of anorexia nervosa/bulimia patients with a chronic course who previously were treated is given little attention in the literature. At the Uppsala University Hospital, a special program was developed for this category. It is assumed that successful therapy requires (1) a combination of therapeutic modalities, (2) a stepwise treatment, (3) a combination of anorexia nervosa and bulimia treatment principles, and (4) a treatment goal that is subjectively valid for the patient. In the present article, “Phase 1” is described. This involves teaching eating control through detailed diet and activity regimens supported by daily talk sessions, body‐awareness therapy, and occupational therapy. “Phase 2” psychotherapy is thereby made possible. Results are promising in that a substantial proportion of patients were able to reach eating and weight goals not attained in previous treatments. Possible ways of improving results, the role of medical management, and implications for treatment of young patients are discussed.

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Relationship of Phenothiazine Intake and Psychiatric Diagnosis to Glucose Level and Tolerance

Cited by 9 publications

References 0 publications

Potential role of prolactin in antipsychotic‐mediated association of schizophrenia and type 2 diabetes

Potential role of prolactin in antipsychotic‐mediated association of schizophrenia and type 2 diabetes

Can Diabetes Mellitus Be Induced by Medication?

Phase 1 treatment for the chronic and previously treated anorexia. Bulimia nervosa patient

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