Relationship of PGC-1α Gene Polymorphism With Insulin Resistance Syndrome in Korean Children

Abstract

This study aimed to investigate the associations between peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) gene Gly482Ser polymorphism (rs8192678) and parameters of insulin resistance in a sample of Korean children. A total of 286 children aged 10 to 12 years old were recruited from local elementary schools. Measured variables included body fat, blood pressures, blood lipids, glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and accelerometer-based physical activity (PA). Significant differences in percentage body fat (P = .016), insulin (P = .013), and HOMA-IR (P = .007) were found according to Gly482Ser genotype, with no significant genotype differences in the other measured variables. The genotype-specific differences in insulin (P = .136) and HOMA-IR (P = .067) were significantly attenuated when adjusted for age, sex, Tanner stage, body fat, and PA. The findings of the study suggest that the genetic effects of the PGC-1α genotypes on parameters of insulin resistance might be modulated by lifestyle factors, including PA and body fatness.

Variants in the PPARGC1A Gene may Influence the Effect of Fat Intake on Resting Metabolic Rate in Obese Women

“…As well as this, A-deletion allele carrier genotype of PPARGC1A (rs11290186) had higher triacylglycerol and insulin blood concentrations. The results are in agreement with earlier similar studies conducted in Iran, Korea, India, and Italy, where PPARGC1A polymorphisms were significantly correlated with effects on insulin resistance and susceptibility to diabetes (Bhat et al, 2007;Fanelli et al, 2005;Ha, Cho, Han, Lee, & Kang, 2015;Shokouhi, Haghani, Borji, & Bakhtiyari, 2015). Once PPARGC1A is activated, it powerfully induces and coordinates gene expressions, which stimulates the mitochondrial oxidative metabolism in brown fat, fibertype switching in skeletal muscles, multiple aspects of the fasted response in liver (Puigserver & Spiegelman, 2003), insulin-mediated glucose disposal (Mootha et al, 2003), ROS (Bhat et al, 2007), and adaptive thermogenesis (Kong et al, 2010).…”

The association between PGC-1α and Alzheimer's disease

“…Moreover, PGC-1α improves glucose tolerance, insulin sensitivity and gluconeogenesis [ 18 ]. Considering that PGC-1α alleviates insulin resistance [ 72 ], it could reduce cognitive impairment related to insulin resistance in the AD brain.…”

PGC-1α, glucose metabolism and type 2 diabetes mellitus

“…However, the mechanism behind the linkage disequilibrium is still not fully understood. Finally, Ha and coworkers report that lifestyle factors, including PA and body fat, may modulate the genetic effects of the PGC-1α Gly482Ser polymorphism on IR in Korean children (Ha et al 2015). Despite some limitations, this cross-sectional study strongly suggests the association between PGC-1α polymorphisms and diabetes.…”