Relationship of p73 gene polymorphism and additional gene-smoking and gene-obesity interaction with non-small cell lung cancer risk

Abstract

AimThe aim of this study was to investigate the impact of G4C14-to-A4T14 polymorphism within P73 gene and additional interactions with current smoking and obesity on non-small cell lung cancer (NSCLC) risk in a Chinese population.ResultsLogistic regression analysis showed a significant association between genotypes of the AT allele in G4C14-to-A4T14 and decreased NSCLC risk. NSCLC risk was significantly lower in carriers of the G4C14-to-A4T14- AT allele than those with GC/GC genotype (AT/AT + GC/AT versus GC/GC), adjusted OR (95%CI) = 0.68 (0.55–0.93). We also found that the OR (95%CI) was 1.88 (1.32-2.47) for current smokers compared with never smokers and 0.69 (0.40–0.95) for obese subjects compared to participants with normal BMI. Never smokers with AT/AT or GC/AT of the G4C14-to-A4T14 genotype have the lowest NSCLC risk compared with smokers with the GC/GC genotype after covariates adjustment, OR (95%CI) = 0.52 (0.26-0.87). Obese participants with G4C14-to-A4T14- AT/AT or GC/AT genotype have the lowest NSCLC risk compared with non- obese subjects with the GC/GC genotype after adjusting for covariates, OR (95% CI) = 0.56 (0.33–0.85).Materials and MethodsA logistic regression model was used to examine the association between G4C14-to-A4T14 polymorphism and NSCLC, and its interaction with current smoking and obesity. The odds ratios (OR) and 95% confident intervals (95%CI) were calculated.ConclusionsOur results support an important association between the G4C14-to-A4T14 and decreased NSCLC risk and additional impact of an interaction between G4C14-to-A4T14 and smoking or obesity on NSCLC risk.

Differential protein‐coding gene and long noncoding RNA expression in smoking‐related lung squamous cell carcinoma

“…For instance, EPHA4, FGFR2, and EGFR are differentially expressed in lung cancer tissues in cigarette smokers . Additionally, the polymorphism of P73 is suggested to be highly associated with susceptibility to smoking‐related lung cancer . Moreover, transcription factors (TFs) have been identified in lung SCC .…”

“…5 Additionally, the polymorphism of P73 is suggested to be highly associated with susceptibility to smoking-related lung cancer. 6 Moreover, transcription factors (TFs) have been identified in lung SCC. 7 In spite of these findings, lung cancer prognosis in clinical practice has not improved.…”

Association between p73 G4C14‐to‐A4T14 polymorphism and lung cancer risk: A systematic review and meta‐analysis

“…The literature search resulted in the identification of 239 documents: 78 studies were excluded after duplicates were removed, and 112 papers were excluded after review of titles and abstracts. The full text of the 49 remaining publications was screened, and, finally, nine studies including 3543 cases and 4435 control individuals were included 18–22,35–38 . The flow chart of the meta‐analysis is shown in Figure 1.…”

“…Liu et al 28 and Meng et al 24 included one more study than Wang with the same conclusion. However, Meng's meta‐analysis omitted several recently published studies 20,22,37–39 . To elucidate the relationship between genetic polymorphism and lung cancer susceptibility, we searched all relevant studies for the purpose of this meta‐analysis.…”

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine

“…This makes the p53 family particularly relevant in interaction with the environment. For example, G × E interactions have been proposed between TP73 polymorphisms and smoking and obesity in modifying lung cancer risk [82].…”