Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression

Abstract

We found evidence for an association between the degree of orthostatic systolic blood pressure drop and WMH volume in the depression group. Since blood pressure drops lead to WMH in animals our findings suggest systolic blood pressure drops may be a factor contributing to these lesions in late-life depression.

The prevalence and risk factors of cerebral microbleeds in patients with Parkinson's disease

“…Depression is more frequent in patients with PD than in the non-PD population [30,31]. It has been suggested that cerebrovascular disease plays an important role in late-life depression [9]. However, we did not find any associations between the presence of CMBs and a history of depression in our patients.…”

“…This association has not been previously reported. Earlier studies have examined the associations between OH and other markers of cerebral small vessel disease, such as WMH, in patients with PD [8,20] and other populations [9,21], but the results have been inconsistent. The pathological substrates of WMH are heterogeneous in their nature and severity, which may partially explain the weak associations between the clinical factors and the radiological findings [22].…”

“…OH is associated with the presence of cerebral small vessel disease, such as white matter hyperintensity (WMH) on MRI in patients with PD [8] as well as in individuals with late-life depression [9]. We therefore hypothesized that OH contributes to CMBs in patients with PD.…”

Cortical Morphology in Patients with Orthostatic Intolerance

“…Several cases have reported that structural abnormalities in the brain may induce OI because specific brain regions modulate the cardiovascular autonomic nervous system (ANS) [4,5]. Moreover, previous studies have demonstrated a volume reduction of the brain in patients with OI [6,7,8]. However, no studies have investigated the cortical morphology of the brain in patients with OI.…”

“…Some evidence suggests that brain abnormalities are associated with OI [4,5,6,7,8]. Several cases have reported that structural abnormalities in the brain may induce OI because specific brain regions modulate the cardiovascular autonomic nervous system (ANS) [4,5].…”