Relationship of obsessive compulsive symptoms/disorder with clozapine: A retrospective study from a multispeciality tertiary care centre

Grover, Sandeep; Hazari, Nandita; Chakrabarti, Subho

doi:10.1016/j.ajp.2015.05.002

Cited by 26 publications

(23 citation statements)

References 26 publications

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“…Previous reports have noted that OCS can occur as early as one month after starting clozapine and as late as five years. 3 This suggests that OCS with clozapine should always be regularly checked for.…”

Section: Discussionmentioning

confidence: 99%

“…6,9 Clozapine is the antipsychotic most associated with OCS. 2,3 One study showed that use of clozapine had twice the risk of being associated with OCS compared with haloperidol, and although the result was found to be statistically insignificant, the severity of the OCS was significant with clozapine. 10 However, there is a question mark as to whether this is because patients on clozapine are more likely to have more resistant and complex psychopathology.…”

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confidence: 99%

“…2,7,11 There have been studies implying that the presence of OCS might be related to the severity of the schizophrenia, higher dose of clozapine administered and longer duration of cloza pine use. 3 It has been suggested that OCS presents more with obsessions rather than compulsions compared with primary OCD. 12 While the association between the use of clozapine, and to a lesser extent olanzapine and risperidone, with OCS is known, the modus operandi for its management is still open to debate.…”

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confidence: 99%

“…Some studies have suggested that OCS often resolve spontaneously, while others have suggested that symptoms reduce when the dose of clozapine is reduced. 3,7 Some studies report an improvement when SSRIs are used. 13,14 We looked at three cases where an antipsychotic with high affinity for 5-HT 2a antagonism was used with the patient later developing new obsessive symptoms.…”

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confidence: 99%

“…1 The prevalence of the presentation has been estimated in the range of 7-64%. [2][3][4] It is postulated that comorbid OCS and schizophrenia has a worse prognosis. 5,6 This comorbidity has been attributed to several causes in the literature, one being the use of antipsychotics that exhibit a high level of antiserotonergic 5-HT 2a antagonism (clozapine, olanzapine, risperidone).…”

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confidence: 99%

See 4 more Smart Citations

Obsessive‐compulsive symptoms: a side‐effect of antipsychotic treatment

Ukaegbu¹,

Dunne²,

Getachew³

2016

Prog Neurol Psychiatry

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Obsessive‐compulsive symptoms (OCS) secondary to antiserotonergic antipsychotic treatment of schizophrenia appear to have a significant prevalence from previous studies but can be very difficult to detect as they are overshadowed by the diagnosis of schizophrenia. Here, the authors describe three cases where patients have developed OCS after starting risperidone in one case, and clozapine in two other cases and how significant improvements can be achieved with SSRIs and, if necessary, cognitive behavioural therapy (CBT).

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%