Relationship of obesity with serum concentrations of leptin, CRP and IL-6 in breast cancer survivors

Babaei, Zeinab; Moslemi, Dariush; Parsian, Hadi; Khafri, Soraya; Pouramir, Mahdi; Mosapour, Abbas

doi:10.1016/j.jnci.2015.09.001

Cited by 42 publications

(37 citation statements)

References 25 publications

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“…A meta-analysis also confirmed a positive association of leptin with breast cancer [13]. Among breast cancer patients, obesity was associated with higher leptin levels than being overweight or normal weight [14]. Positive association of leptin and breast cancer was limited to post-menopausal women in some studies [15].…”

Section: Genotypingmentioning

confidence: 70%

Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer

et al. 2017

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BREAST CANCER is the commonest cancer and second leading cause of cancer death in women worldwide [1]. Currently it is the commonest cancer in Sri Lankan women with a cumulative incidence rate of 2.558 % and age standardised incidence rate (ASR) of 23 per 100,000 women [2]. Multiple factors including genetic, hormonal and environmental factors are associated with breast cancer.Obesity is a well-known risk factor for breast cancer [3]. In obesity adipokine secretion by the subcu-

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Section: Genotypingmentioning

confidence: 70%

Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer

et al. 2017

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“…Several studies suggested that exposure to various carcinogens would increase the risk of cancer and the best known among the possible causes of breast cancer development are inflammatory factors, nutritional parameters, obesity and genetic mutations. 5,6 Currently, surgery, radiotherapy (RT), chemotherapy and hormone therapy are effectively used for the treatment of cancer patients. 7,8 RT, as one of commonly used methods for the treatment of cancer, is able to destroy remaining cancer cells after surgery.…”

Section: Introductionmentioning

confidence: 99%

Pre and post radiotherapy serum oxidant/antioxidant status in breast cancer patients: Impact of age, BMI and clinical stage of the disease

Arjmandi

Moslemi

Zarrini

et al. 2016

Reports of Practical Oncology & Radiotherapy

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“…The level of circulating leptin is proportional to total body fat. Obese patients exhibit high circulating levels of leptin due to leptin resistance[91]. Leptin is a pleiotropic adipokine and pro-inflammatory molecule that belongs to the family of helical cytokines.…”

Section: Leptin and Pcmentioning

confidence: 99%

Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer

Tchio

Harbuzariu

Gonzalez-Perez

2017

WJCO

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Because pancreatic cancer (PC) historically has had poor prognosis and five year survival rates, it has been intensely investigated. Analysis of PC incidence and biology has shown a link between different risk factors such as smoking, alcoholism, and obesity and disease progression. Important factors affecting PC include the epigenomic changes driven by DNA methylation and histone acetylation, and actions of microRNA inducing oncogenic or tumor suppressor effects. Studies have identified markers whose dysregulation seem to play important roles in PC progression. PC markers involve classical histone deacetylases (HDAC), PC stem cell (PCSC), and leptin. In this review, we discuss the role of several PC biomarkers, and the potential crosstalk between HDAC, microRNA, and leptin in PC progression. Dysregulated expression of these molecules can increase proliferation, survival, PCSC, resistance to chemotherapy and tumor angiogenesis. The potential relationships between these molecules are further analyzed using data from The Cancer Genome Atlas and crosstalk pathways generated by the Pathway Studio Platform (Ariadne Genomics, Inc.). Oncogenic miRNA21 and tumor suppressor miRNA200 have been previously linked to leptin signaling. Preliminary analysis of PC biopsies and signaling crosstalk suggests that the main adipokine leptin could affect the expression of microRNA and HDAC in PC. Data analysis suggests that HDAC-microRNA-leptin signaling crosstalk may be a new target for PC therapy.

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Relationship of obesity with serum concentrations of leptin, CRP and IL-6 in breast cancer survivors

Abstract: In conclusion, high leptin levels and alteration in acute phase proteins in obese patients may exaggerate the inflammation status. As inflammation has the potential to increase the susceptibility of the patients to metastasis development, it is necessary to decline its rate.

Cited by 42 publications

References 25 publications

Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer

Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer

Pre and post radiotherapy serum oxidant/antioxidant status in breast cancer patients: Impact of age, BMI and clinical stage of the disease

Histone deacetylases, microRNA and leptin crosstalk in pancreatic cancer

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