Relationship of nerve diameter using S-100 immunohistochemistry with Hirschsprung-associated enterocolitis degrees

Patandianan, Yelisa Tanete; Nurmantu, Farid; Mariana, Nita; Miskad, Upik Andriani; Zainuddin, Andi Alfian; Ahmadwirawan,; Sulmiati, -; Habar, Tommy Rubiyanto; Kusuma, Muhammad Ihwan; Prihantono, Prihantono

doi:10.1016/j.mcpsp.2021.100227

Cited by 1 publication

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“…However, the disease was eponymously named after Harald Hirschsprung at the German Pediatric Society conference in Berlin (1886), where Hirschsprung presented cases of two infants who died of complications due to intestinal obstruction [ 2 , 3 ]. HD, another name for congenital aganglionic megacolon, is a disorder characterized by the absence of ganglion cells in the submucosal plexus and myenteric in the bowel segment, which produces a functional obstruction and proximal dilatation of the affected segment [ 4 , 5 ]. Most HD cases are recognized in newborns or infants, but some cases of a milder form can only be identified in teenagers and adults [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Adult Hirschsprung disease as acute intestinal obstruction: a case report

Kusuma¹,

Sampetoding²,

Bahrun³

2022

Pan Afr Med J

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Most cases of Hirschsprung disease (HD) cases are known in newborns or infants. Nevertheless, some cases with mild symptoms are not identified until acute presentations, such as bowel obstruction present in adolescence or adulthood. We reported a 25-year-old male with a history of chronic constipation from childhood presenting with bowel obstruction due to HD. As an emergency operation, the Hartmann procedure was performed to overcome the obstruction. The histological result showed an aganglionic segment, confirming HD. We plan a definitive Duhamel endorectal pull-through surgery three to six months in the future. Adult HD is uncommon, and clinicians should be aware when patients with histories of chronic constipation from a young age present with intestinal obstruction.

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