Relationship of MR imaging of submandibular glands to hyposalivation in Sjögren's syndrome

Kojima, Itaru; Sakamoto, Maya; Iikubo, Masahiro; Shimada, Yusuke; Nishioka, Takashi; Sasano, Takashi

doi:10.1111/odi.12941

Cited by 15 publications

(16 citation statements)

References 23 publications

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“…The typical finding in pSS is the presence of multiple high-signal-intensity spots, which are thought to arise after leakage of saliva from peripheral ducts. Kojima et al [ 34 ] did not find correlations between MR sialography findings and salivary flow rate, which can be explained by the fact that MR sialography visualizes the ductal system instead of saliva-producing acinar cells. Although MR sialography seems to be more sensitive to detect early disease, magnetic resonance imaging (MRI) provides more information on pathological changes in the glandular parenchyma, as we describe below [ 35 ].…”

Section: Radiology Techniquesmentioning

confidence: 99%

“…The characteristic finding in salivary glands of pSS patients is a heterogeneous signal-intensity distribution on T1- and T2-weighted images. The multiple hypointense and hyperintense areas cause a so-called salt and pepper appearance [ 34 ]. In the advanced stages of pSS, cystic changes can be found with MRI, which are thought to arise from destruction of the salivary gland parenchyma and the presence of fibrosis and fatty infiltration [ 3 , 31 , 36 ].…”

Section: Radiology Techniquesmentioning

confidence: 99%

“…Kojima et al [ 34 ] demonstrated, in a group of pSS patients, that a higher degree of glandular heterogeneity and a smaller volume of the parotid and submandibular glands on MRI images were associated with lower stimulated and unstimulated salivary flow rates. These associations were even more pronounced for the submandibular glands, compared to the parotid glands, indicating that MRI findings of the submandibular glands can reflect hyposalivation.…”

Section: Radiology Techniquesmentioning

confidence: 99%

“…These associations were even more pronounced for the submandibular glands, compared to the parotid glands, indicating that MRI findings of the submandibular glands can reflect hyposalivation. A possible explanation for the differences in associations between both glands is that the function of the submandibular gland is impaired earlier in the disease process than the function of the parotid gland [ 34 , 44 , 45 ]. Collection of saliva from the individual glands would be a more direct approach to relate MRI findings with salivary gland functioning in pSS.…”

Section: Radiology Techniquesmentioning

confidence: 99%

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Imaging in Primary Sjögren’s Syndrome

Ginkel

Glaudemans

Vegt

et al. 2020

JCM

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Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by dysfunction and lymphocytic infiltration of the salivary and lacrimal glands. Besides the characteristic sicca complaints, pSS patients can present a spectrum of signs and symptoms, which challenges the diagnostic process. Various imaging techniques can be used to assist in the diagnostic work-up and follow-up of pSS patients. Developments in imaging techniques provide new opportunities and perspectives. In this descriptive review, we discuss imaging techniques that are used in pSS with a focus on the salivary glands. The emphasis is on the contribution of these techniques to the diagnosis of pSS, their potential in assessing disease activity and disease progression in pSS, and their contribution to diagnosing and staging of pSS-associated lymphomas. Imaging findings of the salivary glands will be linked to histopathological changes in the salivary glands of pSS patients.

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Section: Radiology Techniquesmentioning

confidence: 99%

Section: Radiology Techniquesmentioning

confidence: 99%

Section: Radiology Techniquesmentioning

confidence: 99%

Section: Radiology Techniquesmentioning

confidence: 99%

See 2 more Smart Citations

Imaging in Primary Sjögren’s Syndrome

Ginkel

Glaudemans

Vegt

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…Furthermore, heterogeneous signal intensity distribution in T1-and fat-suppressed T2-weighted MRI in patients with SS has higher specificity in the submandibular gland than in the parotid gland [28]. The heterogeneity and smaller volume in the submandibular gland observed in MRI may be a good predictor for hyposalivation related to the progression of pSS [29].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 98%

Imaging methods in primary Sjögren’s syndrome as potential tools of disease diagnostics and monitoring

Świecka¹,

Maślińska²,

Paluch³

et al. 2019

Reumatologia

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Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that affects exocrine glands, especially salivary and lacrimal glands, leading to their progressive destruction. With highly differentiated clinical course the approach to the definition of pSS is constantly evolving and the pSS classification criteria have been modified over the past years. In the past sialography and scintigraphy were frequently used in pSS diagnostics. Recently no imaging method has been included in the pSS classification criteria. That raises the question about the benefits of using novel imaging techniques such as ultrasonography, elastography and magnetic resonance imaging to diagnose and monitor pSS patients. The purpose of this review is to evaluate the advantages and limitations of widely used imaging methods in pSS and their possible future development.

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Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome

et al. 2020

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Objectives/Hypothesis To compare the results of magnetic resonance imaging with magnetic resonance sialography (MRSIAL) and the clinical and laboratory characteristics in a well‐characterized cohort of patients with primary or secondary Sjögren's syndrome (SS) meeting the American–European Consensus Group criteria. Study Design: Retrospective, observational, monocentric study. Methods Thirty‐six patients (81% female, mean age = 48 ± 35 years) with primary or secondary SS who underwent MRSIAL were included in the study. Results MRSIAL revealed characteristic radiological signs in the parotid, sublingual, and submandibular salivary glands in 35/36 patients (97%). Patients presenting with anti‐Sjögren's syndrome–related antigen A (SSA) autoantibodies showed more often fatty infiltration, a “pepper‐and‐salt” appearance, ductal stenosis, and/or ductal dilation of the parotid gland (88%, 88%, and 72% respectively) than patients negative for anti‐SSA (12%, 4%, and 28% respectively). MRSIAL demonstrated signs characteristic of SS in all 11 patients with negative minor salivary gland biopsy. For 15 patients undergoing ultrasound examination only, 11 (73%) had SS findings, but all 15 had SS findings on MRSIAL. Two cases of parotid lymphoma were detected by MRSIAL (6%). Conclusions MRSIAL is a reliable technique to detect glandular anomalies in patients with SS, and seems to provide a valuable aid in the diagnosis of SS. Level of Evidence 4 Laryngoscope, 131:E83–E89, 2021

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Relationship of MR imaging of submandibular glands to hyposalivation in Sjögren's syndrome

Abstract: Magnetic resonance image features of heterogeneity and smaller volume in the submandibular gland are reliable for predicting hyposalivation related to the progression of Sjögren's syndrome.

Cited by 15 publications

References 23 publications

Imaging in Primary Sjögren’s Syndrome

Imaging in Primary Sjögren’s Syndrome

Imaging methods in primary Sjögren’s syndrome as potential tools of disease diagnostics and monitoring

Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome

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