Relationship of maternal warfarin therapy in pregnancy to chondrodysplasia punctata: Report of a case

Maternal exposure to statins and risk for birth defects: A case‐series approach

“…Spontaneous case reports can have value in very limited circumstances, in particular, where an exposure is quite rare and the outcome both rare and distinctive [Shepard, 1991; Carey, 2008]. Two examples where this study design has been helpful include the association between high‐dose, prolonged fluconazole use and a distinctive phenotype [Lopez‐Rangel and Van Allen, 2005], and the association between warfarin exposure and chondrodysplasia punctata [Shaul et al, 1975; Pauli et al, 1976; Collins et al, 1977], both of which were largely identified through case reports [Reprotox, 2008; TERIS (Teratogen Information System), 2008].…”

Malformations due to warfarin: A case report

“…Two patients' cardiac defect was unidentified because of short survey. Obstructive lesions in cases 1, 4, 6, and 7 are noteworthy [2,3,5,11]. In case 9, a 17-year-old patient is reported who had had atrial flutter at birth.…”

Foetal Warfarin Syndrome—a complex airway problem

“…Abbott et al (1977) suspected laryngeal collapse prior to the death of a neonate with FWS but a post-mortem only revealed laryngeal calcification. Collins et al (1977) performed a laryngoscopy and bronchoscopy on a neonate with FWS who was suffering apnoeic episodes; this revealed no abnormality.…”

“…CNS abnormalities and seizures are not part of the FWS but frequently occur in infants who have been exposed to second or third trimester warfarin in conjunction with FWS. It can be difficult on occasions to distinguish fits or hypoxia as causes for syncopal episodes (Collins et al, 1977).…”