Relationship of leukocytes, platelet indices and adipocytokines in metabolic syndrome patients

Abdel-Moneim, Adel; Mahmoud, Basant; Sultan, Eman A.; Taha, Rania H.

doi:10.1016/j.dsx.2018.12.016

Cited by 20 publications

(27 citation statements)

References 40 publications

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“…In this cohort we have previously recorded elevated levels of PAI‐1 supporting this thesis 9 . The increase PCs and activity in MetS could contribute to the increase risk of ASCVD in MetS by promoting atherothrombosis 10–12,24,26 . Furthermore, HDL has been reported to have anti‐platelet and other anti‐thrombotic effects 20,21 .…”

Section: Discussionsupporting

confidence: 64%

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The platelet to high density lipoprotein ‐cholesterol ratio is a valid biomarker of nascent metabolic syndrome

Jialal

Adams‐Huet

2020

Diabetes Metabolism Res

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Aims The metabolic syndrome (MetS) is a major global problem, and inflammation and insulin resistance appear to be key underpinnings in this cardio‐metabolic cluster. MetS predisposes to an increased risk of diabetes and atherosclerotic cardiovascular disease (ASCVD). It has a procoagulant diathesis which included increased platelet activity and impaired fibrinolysis. High density lipoprotein (HDL) appears to be anti‐thrombotic. Accordingly, we examined the ratios between platelets to HDL‐cholesterol(C) and adiponectin (Adipo) in patients with nascent MetS without the confounding of diabetes, ASCVD and smoking to determine their validity as biomarkers of MetS. Methods Patients with nascent MetS (n = 58) and matched controls (n = 44) were recruited. Fasting blood samples were obtained for complete blood counts, basic metabolic panel, lipids, insulin, and Adipo. Ratios of platelets to HDL‐C and Adipo were calculated. Results Following adjustment for adiposity, only the platelet: HDL ratio was significantly increased in MetS and increased with severity of MetS. Receiver operating characteristic curve analysis showed that the platelet: HDL‐C area under the curve (AUC) significantly added to both platelets and platelet lymphocyte ratio AUCs. Also the platelet: HDL‐C ratio correlated with all cardio‐metabolic features of MetS, high sensitivity C‐reactive protein, insulin resistance chemerin, and leptin. Conclusions The ratio of platelets: HDL‐C is significantly increased in patients with nascent MetS and appear to be a valid biomarker of MetS. It could also emerge as a biomarker for athero‐thrombotic risk. However, these preliminary findings need confirmation in large prospective studies.

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Section: Discussionsupporting

confidence: 64%

“…Some groups have claimed that the platelet count (PC) and the platelet lymphocyte ratio (PLR) are valid biomarker of MetS and correlated with the severity of MetS 10–14 . However these are not uniform observations and in a prospective study the PC failed to predict MetS 15–17 .…”

Section: Introductionmentioning

confidence: 99%

The platelet to high density lipoprotein ‐cholesterol ratio is a valid biomarker of nascent metabolic syndrome

Jialal

Adams‐Huet

2020

Diabetes Metabolism Res

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“…In particular, adiponectin deficient mice show increased platelet response to the proaggregating agents and thrombosis tendency [66], high adiponectin plasma concentrations are associated with a decreased risk of coronary artery diseases and increased bioavailability of NO [67]. Both hyperleptinemia and hypoadiponectinemia in MS are associated with increases in leukocytes and platelet indices with platelet count, platelet distribution width (PDW), mean platelet volume (MPV) values, and platelets/lymphocyte ratio significantly higher in MS patients than in healthy subjects [68].…”

Section: Platelet Alterations In Central Obesitymentioning

confidence: 99%

Influence of Cardiometabolic Risk Factors on Platelet Function

Barale

Russo

2020

IJMS

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Platelets are key players in the thrombotic processes. The alterations of platelet function due to the occurrence of metabolic disorders contribute to an increased trend to thrombus formation and arterial occlusion, thus playing a major role in the increased risk of atherothrombotic events in patients with cardiometabolic risk factors. Several lines of evidence strongly correlate metabolic disorders such as obesity, a classical condition of insulin resistance, dyslipidemia, and impaired glucose homeostasis with cardiovascular diseases. The presence of these clinical features together with hypertension and disturbed microhemorrheology are responsible for the prothrombotic tendency due, at least partially, to platelet hyperaggregability and hyperactivation. A number of clinical platelet markers are elevated in obese and type 2 diabetes (T2DM) patients, including the mean platelet volume, circulating levels of platelet microparticles, oxidation products, platelet-derived soluble P-selectin and CD40L, thus contributing to an intersection between obesity, inflammation, and thrombosis. In subjects with insulin resistance and T2DM some defects depend on a reduced sensitivity to mediators-such as nitric oxide and prostacyclin-playing a physiological role in the control of platelet aggregability. Furthermore, other alterations occur only in relation to hyperglycemia. In this review, the main cardiometabolic risk factors, all components of metabolic syndrome involved in the prothrombotic tendency, will be taken into account considering some of the mechanisms involved in the alterations of platelet function resulting in platelet hyperactivation.

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“…On the other hand, previous studies on the association between platelets and UACR are very few; nevertheless, they show an independent relationship between mean platelet volume, increased albuminuria, and other microvascular complications such as retinopathy in T2DM [ 60 , 61 ]. Platelet activity plays a major role in the pathogenesis of endothelial injury and vascular disease [ 62 ]; moreover, it has been associated with hyperglycemia [ 63 ] and insulin resistance [ 64 , 65 , 66 ], which in turn are associated with increased albuminuria [ 11 ]. Although platelet count seems to share common pathways to other risk factors associated with increased albuminuria, in the current analysis, such association was independent of insulin resistance, diabetes, liver fibrosis, and other potential confounders.…”

Section: Discussionmentioning

confidence: 99%

Albuminuria Is Associated with Hepatic Iron Load in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome

Abbate

Montemayor

Mascaró

et al. 2021

JCM

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Background: Increased albuminuria is associated with increased serum ferritin, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Liver iron accumulation is also related to hyperferritinemia, insulin resistance, and NAFLD; however, there is no evidence on its relationship with albuminuria. Aims: To assess the relationship between hepatic iron load and urine albumin-to-creatinine ratio (UACR) in patients with metabolic syndrome (MetS) and NAFLD. Methods: In total, 75 MetS and NAFLD patients (aged 40–60 years, BMI 27–40 kg/m2) were selected from a cohort according to available data on hepatic iron load (HepFe) by magnetic resonance imaging (MRI). Subjects underwent anthropometric measurements, biochemistry testing, and liver MRI. Increased albuminuria was defined by UACR. Results: UACR correlated with NAFLD, HepFe, triglycerides, serum ferritin, fasting insulin, insulin resistance (calculated using the homeostatic model assessment for insulin resistance—HOMA-IR- formula), and platelets (p < 0.05). Multiple regression analysis adjusted for gender, age, eGFR, HbA1c, T2DM, and stages of NAFLD, found that HepFe (p = 0.02), serum ferritin (p = 0.04), fasting insulin (p = 0.049), and platelets (p = 0.009) were associated with UACR (R2 = 0.370; p = 0.007). UACR, liver fat accumulation, serum ferritin, and HOMA-IR increased across stages of HepFe (p < 0.05). Patients with severe NAFLD presented higher HepFe, fasting insulin, HOMA-IR, and systolic blood pressure as compared to patients in NAFLD stage 1 (p < 0.05). Conclusion: Hepatic iron load, serum ferritin, fasting insulin, and platelets were independently associated with albuminuria. In the context of MetS, increased stages of NAFLD presented higher levels of HepFe. Higher levels of HepFe were accompanied by increased serum ferritin, insulin resistance, and UACR. The association between iron accumulation, MetS, and NAFLD may represent a risk factor for the development of increased albuminuria.

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Relationship of leukocytes, platelet indices and adipocytokines in metabolic syndrome patients

Cited by 20 publications

References 40 publications

The platelet to high density lipoprotein ‐cholesterol ratio is a valid biomarker of nascent metabolic syndrome

The platelet to high density lipoprotein ‐cholesterol ratio is a valid biomarker of nascent metabolic syndrome

Influence of Cardiometabolic Risk Factors on Platelet Function

Albuminuria Is Associated with Hepatic Iron Load in Patients with Non-Alcoholic Fatty Liver Disease and Metabolic Syndrome

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