Relationship of leukaemias with long-term ambient air pollution exposures in the adult Danish population

Abstract

Background Few population-based epidemiological studies of adults have examined the relationship between air pollution and leukaemias. Methods Using Danish National Cancer Registry data and Danish DEHM-UBM-AirGIS system-modelled air pollution exposures, we examined whether particulate matter (PM2.5), black carbon (BC), nitrogen dioxide (NO2) and ozone (O3) averaged over 1, 5 or 10 years were associated with adult leukaemia in general or by subtype. In all, 14,986 adult cases diagnosed 1989–2014 and 51,624 age, sex and time-matched controls were included. Separate conditional logistic regression models, adjusted for socio-demographic factors, assessed exposure to each pollutant with leukaemias. Results Fully adjusted models showed a higher risk of leukaemia with higher 1-, 5- and 10-year-average exposures to PM2.5 prior to diagnosis (e.g. OR per 10 µg/m3 for 10-year average: 1.17, 95% CI: 1.03, 1.32), and a positive relationship with 1-year average BC. Results were driven by participants 70 years and older (OR per 10 µg/m3 for 10-year average: 1.35, 95% CI: 1.15–1.58). Null findings for younger participants. Higher 1-year average PM2.5 exposures were associated with higher risks for acute myeloid and chronic lymphoblastic leukaemia. Conclusion Among older adults, higher risk for leukaemia was associated with higher residential PM2.5 concentrations averaged over 1, 5 and 10 years prior to diagnosis.

Ambient Fine Particulate Matter and Cancer: Current Evidence and Future Perspectives

“…122 Nonetheless, based on the adult Danish population, the study showed that those who suffered a higher risk of leukemia were exposed to higher concentrations of PM 2.5 prior to diagnosis [OR 1.17 (95%CI: 1.03, 1.32) per 10 μg/m 3 for 10 year average], further study extended this relationship in PM 2.5 components such as black carbon, NH 4 , and NO 3 in the ambient air. 120,121 Jin et al 146 pointed out that PM 2.5 exposure at low doses induced ROS generation which regulated transcription of inflammatory gene, and promoted leukemia progression via the activation of NF-κB and STAT3.…”

For the aged: A novel PM2.5 concentration forecasting method based on spatial-temporal graph ordinary differential equation networks in home-based care parks

“…Compared with coarser atmospheric particulate matter, fine particulate matter has a small particle size and is rich in a large amount of toxic and harmful substances, and it has a long residence time in the atmosphere, so it has a greater impact on human health and atmospheric environmental quality. Researches have shown that the increase in PM2.5 concentration is closely related to the increase in the risk of leukemia in the elderly (Puett et al, 2020).…”

Influencia de la contaminación ambiental sobre las agudizaciones del asma bronquial en un área de baja contaminación

“…En la actualidad, existe suficiente evidencia científica, a través de estudios experimentales en animales y epidemiológicos en humanos, que permite establecer un vínculo causal entre la exposición a contaminantes ambientales y el desarrollo y progresión de enfermedades neoplásicas, especialmente del cáncer de pulmón [53][54][55][56] . Sin embargo, los resultados sobre la relación con otros tipos de tumores han sido menos consistentes [57][58][59][60][61] .…”

“…El estudio de la relación de los tumores hematopoyéticos, como las leucemias y los linfomas, con la contaminación ha sido motivo creciente de estudio en los últimos años 57,61 , dada la susceptibilidad de este tipo de tumores a otros agentes externos como los virus o la radiación. A pesar de ello, los resultados no han sido concluyentes.…”

“…Por el contrario, en una investigación que analizaba la exposición a largo plazo a material particulado en Dinamarca, sus autores reportaron un aumento del riesgo de desarrollar una leucemia tras 10 años de exposición a niveles más altos de PM2,5 en la población adulta (OR 1,17 por 10 µg/m 3 ) 61 .…”