Relationship of lethal toxic dose to body weight of the mouse

Lamanna, Carl; Hart, Ernest

doi:10.1016/0041-008x(68)90104-x

Cited by 32 publications

(20 citation statements)

References 4 publications

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“…In a study of the effects of over a dozen compounds in only mice, the majority, but not all, demonstrated a linear relationship of toxicity (LD 50 , lethal dose in 50% of subjects) to body weight (Lamanna and Hart, 1968). The fact that most substances followed a linear trend indicates that using a direct milligram per kilogram conversion might be a good starting point for many drugs; however, the few substances that did not follow the linear trend show that, as expected, this conversion will not be applicable every time (see Riviere et al, 1997 for an allometric analysis of 44 veterinary drugs across species showing similar findings).…”

Section: Pharmacokineticsmentioning

confidence: 99%

Psychostimulants and Cognition: A Continuum of Behavioral and Cognitive Activation

et al. 2013

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Section: Pharmacokineticsmentioning

confidence: 99%

Psychostimulants and Cognition: A Continuum of Behavioral and Cognitive Activation

et al. 2013

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“…The problem of dealing with the possible difference in sensitivity among animals of the same species but different body weights has been discussed in a number of works (5,6). …”

Section: Sfmentioning

confidence: 99%

Extrapolation of experimental data from animals to man.

Krasovskiĭ¹

1976

Environ Health Perspect

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Conditions for extrapolating toxicologic data from animals to man were studied. In the search for general regularities associated with the comparative sensitivity of humans and various species of animals to toxins, it was shown that the toxicity parameters of compounds and the biological constants of mammals correlate with body weight. This relationship is well described by a rectilinear regression equation which holds for more than 100 of the most diverse mammalian biological constants. The toxicity parameters for 80% of the substances also are subordinated to this regularity. This made it possible to develop a computational method for extrapolating toxicologic data from animals to the "average" man. In order to increase the reliability of extrapolation, it is necessary to take into consideration the limits of variability of sensitivity of various population contingents to the effect of chemical compounds, estimate the accuracy of establishing the threshold and no-effect doses of substances under chronic experiment conditions with animals and determine the maximally possible error associated with extrapolating experimental data to the "average" man. In this respect, it is advisable to use a coefficient of reserve whose value should not be less than 10 in order to ensure safe conditions for the transfer of the results of toxicologic studies to public health practice.

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“…Clostridium botulinum produces seven antigenically distinct neurotoxins diVerentiated serologically by speciWc neutralization [2]. These have been designated as serotypes A through G and are the most toxic substances known [3]. Thus, seven monovalent vaccines are required if full immunologic protection against botulinum neurotoxins is to be achieved.…”

mentioning

confidence: 99%