Relationship of Left Ventricular Diastolic Function to Obesity and Overweight in a Japanese Population With Preserved Left Ventricular Ejection Fraction

Lee, Seitetsu L.; Daimon, Masao; Tullio, Marco R. Di; Homma, Shunichi; Nakao, Tomoko; Kawata, Takayuki; Kimura, Kôichi; Shinozaki, Tomohiro; Hirokawa, Megumi; Kato, Tomoko S.; Mizuno, Yoshiko; Watanabe, Masafumi; Yatomi, Yutaka; Yamazaki, Tsutomu; Komuro, Issei

doi:10.1253/circj.cj-16-0381

Cited by 18 publications

(13 citation statements)

References 40 publications

(16 reference statements)

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“…This epidemic poses important health concerns due to the association between overweight and obesity and adverse health effects such as cardiovascular diseases [1,2]. Actually, it has been shown that obesity predisposes to changes in cardiac morphology and ventricular function, contributing to diastolic dysfunction and heart failure (HF) [3,4], particularly the phenotype with preserved ejection fraction (HFpEF). HFpEF is characterized by abnormal relaxation and increased passive stiffness that manifests as prolonged isometric relaxation, slow left ventricle filling and increased diastolic stiffness [5].…”

Section: Introductionmentioning

confidence: 99%

Can Adiponectin Help us to Target Diastolic Dysfunction?

Francisco

Neves

Falcão-Pires

et al. 2016

Cardiovasc Drugs Ther

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Adiponectin is the most abundant adipokine and exhibits anti-inflammatory, antiatherogenic and antidiabetic properties. Unlike other adipokines, it inversely correlates with body weight and obesity-linked cardiovascular complications. Diastolic dysfunction is the main mechanism responsible for approximately half of all heart failure cases, the so-called heart failure with preserved ejection fraction (HFpEF), but therapeutic strategies specifically directed towards these patients are still lacking. In the last years, a link between adiponectin and diastolic dysfunction has been suggested. There are several mechanisms through which adiponectin may prevent most of the pathophysiologic mechanisms underlying diastolic dysfunction and HFpEF, including the prevention of myocardial hypertrophy, cardiac fibrosis, nitrative and oxidative stress, atherosclerosis and inflammation, while promoting angiogenesis. Thus, understanding the mechanisms underlying adiponectin-mediated improvement of diastolic function has become an exciting field of research, making adiponectin a promising therapeutic target. In this review, we explore the relevance of adiponectin signaling for the prevention of diastolic dysfunction and identify prospective therapeutic targets aiming at the treatment of this clinical condition.

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Section: Introductionmentioning

confidence: 99%

Can Adiponectin Help us to Target Diastolic Dysfunction?

Francisco

Neves

Falcão-Pires

et al. 2016

Cardiovasc Drugs Ther

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“…Racial differences in fetal LV twist: This is the first study examining the feasibility and reproducibility of LV twist measurements with 2DSTE in an Asian population, while one similar study was conducted in a Western population. 15) As described in the discussion, there are racial differences in LV function and echocardiographic windows, [16][17][18][19] and this is one of advantages of our study. On the other hand, it also should be recognized there might be racial differences in the interpretation of our results.…”

Section: Discussionmentioning

confidence: 92%

“…However, physical and racial differences can influence cardiac function and echocardiographic windows. [16][17][18][19] Since fetal LV twist has not been reported in Asians, we aimed to evaluate the feasibility and reproducibility of fetal LV twist by 2DSTE in a Japanese population.…”

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confidence: 99%

Feasibility and Reproducibility of Fetal Left Ventricular Twist Using Two-Dimensional Speckle-Tracking Analysis in a Japanese Population

et al. 2019

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In fetal echocardiography, conventional parameters for assessing cardiac function are limited because of limited echocardiographic windows or the fetus' position. We aimed to evaluate the feasibility and reproducibility of fetal left ventricular (LV) twist by two-dimensional, speckle-tracking echocardiography (2DSTE) in a Japanese population.We included 55 normal fetuses at gestational ages between 21 and 36 weeks. Subjects with adverse maternal health issues were excluded. LV twist was calculated as the net difference between LV basal and apical rotation at end-systole estimated with 2DSTE.We were able to analyze the 2DSTE images in 44 cases (80%). The mean (±SE) apical rotation, basal rotation, and LV twist were 7.88 ± 0.77, −3.68 ± 0.50, and 11.1 ± 0.75 degrees, respectively. We could not analyze 11 cases (20%) because of poor image quality due to fetal position in five cases (45.5%), failure to track the endocardium because of blurred images in five cases (45.5%), and failure to obtain images of the heart due to the presence of the placenta in front of the fetus in one case (9.1%). There were no significant differences in the demographic data between pregnant women in whom LV twist analysis was feasible and not feasible. The intra-and interobserver intraclass correlation coefficients were 0.67 and 0.64, respectively.LV twist analysis by 2DSTE in the fetus was feasible in a substantial population and may provide new insight into cardiac function during the prenatal period. On the other hand, its reproducibility was moderate and needs to be improved.(Int Heart J 2019; 60: 671-678)

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“…Desse modo, torna-se necessária uma avaliação mais minuciosa para corrigir tais fatores e estabelecer o papel do IMC na graduação da DDVE. 15,16 A presença de DAC mostrou-se significativa na população com DDVE, mas não é possível classificá-la como fator de risco independente para esta população, visto que a presença de DAC foi observada a partir da história médica pregressa dos participantes. Outros estudos, no entanto, executaram análises laboratoriais e de imagem para avaliar a mesma associação, que se mostra controversa.…”

Section: Tabela 1 -Parâmetros Clínicosunclassified

Association among Dyspnea and the Degrees of Diastolic Dysfunction at Echocardiography

Passos¹,

Teixeira²,

Bortolon³

et al. 2018

Arquivos Brasileiros De Cardiologia - Imagem Cardiovascular

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Introdução: A disfunção diastólica do ventrículo esquerdo (DDVE) pode levar a insuficiência cardíaca com fração de ejeção preservada. O ecocardiograma, em especial o Doppler tecidual, é o principal exame utilizado. A clínica geralmente cursa com dispneia, avaliada pela escala modified Medical Research Council (mMRC). Entretanto, existem poucos estudos que investiguem qual é a associação entre o sintoma e a disfunção. Objetivo: Avaliar se a queixa de dispneia se associa com a progressão da DDVE e se há relação entre mMRC e os graus de DDVE. Métodos: Estudo caso-controle e transversal, com 60 participantes, com avaliação clínica (mMRC) e ecocardiográfica (parâmetros bidimensionais, Doppler espectral e tecidual). Dentre os participantes avaliados, 49 configuraram o grupo caso (DDVE com dispneia) e 11 o grupo controle (DDVE sem dispneia). Foram excluídos participantes com comorbidades ou outras alterações ecocardiográficas relacionadas à dispneia. Resultados: A média de idade foi de 61,7 anos (± 7,9), sendo 72% mulheres. Do total, 82% dos participantes apresentaram dispneia. Destes, 82% apresentaram DDVE grau I. Todos apresentaram função ventricular sistólica preservada. A presença de dispneia se associou com o grau de DDVE (p = 0,04), relação que não se observou com a intensidade do sintoma (p = 0,72). Conclusão: Houve associação entre a presença de dispneia e grau de DDVE, porém não houve relação entre a progressão da dispneia e a evolução da DDVE. O aumento do átrio esquerdo e a presença de doença arterial coronariana foram associadas com graus mais avançados de DDVE.

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Relationship of Left Ventricular Diastolic Function to Obesity and Overweight in a Japanese Population With Preserved Left Ventricular Ejection Fraction

Cited by 18 publications

References 40 publications

Can Adiponectin Help us to Target Diastolic Dysfunction?

Can Adiponectin Help us to Target Diastolic Dysfunction?

Feasibility and Reproducibility of Fetal Left Ventricular Twist Using Two-Dimensional Speckle-Tracking Analysis in a Japanese Population

Association among Dyspnea and the Degrees of Diastolic Dysfunction at Echocardiography

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