Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma

Eggleston, Peyton A.; Rosenstreich, David L.; Lynn, Henry; Gergen, Peter J.; Baker, Dean; Kattan, Meyer; Mortimer, Kathleen; Mitchell, Herman; Ownby, Dennis R.; Slavin, Raymond G.; Malveaux, Floyd J.

doi:10.1016/s0091-6749(98)70272-6

Cited by 305 publications

(245 citation statements)

References 25 publications

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“…17,25 Some previous studies have had difficulties in detecting Alternaria allergens in environmental samples with mAb-based assays, even among populations in which Alternaria sensitivity and exposure to Alternaria spores are known to be common. 22,39,40 We measured concentrations of A alternata antigens in dust with a polyclonal anti-A alternata antibody assay, which was the best available assay at the time of the survey. Because the polyclonal rabbit anti-A alternata antibodies (Greer Laboratories, Inc) were raised against the cellular antigens derived from whole mycelial extracts of A alternata, they bind to a variety of antigenic components, including, but not limited to, known allergens.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Alternaria alternata in US homes is associated with asthma symptoms

Salo

Arbes

Sever

et al. 2006

Journal of Allergy and Clinical Immunology

203

135

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Section: Discussionmentioning

confidence: 99%

Exposure to Alternaria alternata in US homes is associated with asthma symptoms

Salo

Arbes

Sever

et al. 2006

Journal of Allergy and Clinical Immunology

203

135

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“…36 In all, increased exposure to allergens, particularly dust mites and cockroaches, is related to an increased risk for the development of asthma. [37][38][39] Building Level While researchers have established that asthma is an ever-growing burden, more so for some USA communities than others, they have not yet firmly delineated the issues that put people at highest risk for being exposed to indoor allergens, and/or developing asthma. Most asthma research in the USA focuses on in-unit and other individual-level triggers, with a few exceptions.…”

Section: Asthma and Indoor Allergensmentioning

confidence: 99%

Are Building-Level Characteristics Associated with Indoor Allergens in the Household?

et al. 2011

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Building-level characteristics are structural factors largely beyond the control of those who live in them. We explored whether building-level characteristics and indoor allergens in the household are related. We examined the relationship between building-level characteristics and indoor allergens: dust mite, cat, cockroach, and mouse. Building-level characteristics measured were presence of pests (seeing cockroaches and rodents), building type (public housing, buildings zoned commercially and residentially, and building size), and building condition (building age and violations). Allergen cutpoints were used for categorical analyses and defined as follows: dust mite: 90.25 μg/g; cat: 91 μg/g; cockroach: 91 U/g; mouse: 91.6 μg/g. In fully adjusted linear analyses, neither dust mite nor cat allergen were statistically significantly associated with any building-level characteristics. Cockroach allergen was associated with the presence of cockroaches (2.07; 95% CI, 1.23, 3.49) and living in public housing (2.14; 95% CI, 1.07, 4.31). Mouse allergen was associated with the presence of rodents (1.70; 95% CI, 1.29, 2.23), and building size: living in a low-rise (G8 floors; 0.60; 95% CI, 0.42, 0.87) or high-rise (8+floors; 0.50; 95% CI, 0.29, 0.88; compared with house/duplex). In fully adjusted logistic analyses, cat allergen was statistically significantly associated with living in a high-rise (6.29; 95% CI, 1.51, 26.21; compared with a house/duplex). Mouse allergen was associated with living in public housing (6.20; 95% CI, 1.01, 37.95) and building size: living in a low-rise (0.16; 95% CI, 0.05, 0.52) or high-rise (0.06; 95% CI, 0.01, 0.50; compared with a house/duplex). Issues concerning building size and public housing may be particularly critical factors in reducing asthma morbidity. We suggest that future research explore the possible improvement of these factors through changes to building code and violations adherence, design standards, and incentives for landlords.

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“…4 -20 Studies that have implicated certain risk factors for asthma, however, are often limited by small sample size or a restricted focus on a specific age group, geographic distribution, or socioeconomic strata. 4,10,17,21 Thus, the relative contribution of specific allergens or other residential exposures to asthma for children and adolescents in the United States is poorly defined. Moreover, there has not been any attempt to estimate the overall contribution of indoor allergens or residential exposures to asthma.…”

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confidence: 99%

Contribution of Residential Exposures to Asthma in US Children and Adolescents

et al. 2001

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ABSTRACT. Context. Residential exposures are recognized risk factors for asthma, but the relative contribution of specific indoor allergens and their overall contribution to asthma among older children and adolescents in the United States are unknown.Objective. To estimate the relative contributions, population-attributable risks, and costs of residential risk factors for doctor-diagnosed asthma.Design. Nationally representative, cross-sectional survey conducted from 1988 to 1994.Setting and Participants. A total of 5384 children who were 6 to 16 years old and participated in the National Health and Nutrition Examination Survey III, a survey of the health and nutritional status of children and adults in the United States.Main Outcome Measure. Doctor-diagnosed asthma, as reported by the parent.Results. Five hundred three of 5384 children and adolescents (11.4%) had doctor-diagnosed asthma. After adjusting for age, gender, race, urban status, region of country, educational attainment of the head of household, and poverty, predictors of doctor-diagnosed asthma included a history of allergy to a pet (odds ratio [OR: 2.4; 95% confidence interval [CI]: 1.7, 3.3), presence of a pet in the household (OR: 1.5; 95% CI: 1.1, 2.1), and immediate hypersensitivity to dust mite (OR: 1.5; 95% CI: 1.05, 2.0), Alternaria (OR: 1.9; 95% CI: 1.3, 2.8), and cockroach allergens (OR: 1.4; CI: 1.04, 1.9). Family history of atopy (OR: 1.7; 95% CI: 1.1, 2.7) and diagnosis of allergic rhinitis (OR: 2.1; CI: 1.1, 3.7) were also predictors for asthma. The population-attributable risk of having 1 or more residential exposures associated with doctor-diagnosed asthma was 44.4% (95% CI: 29 -60), or an estimated 2 million excess cases. The attributable cost of asthma resulting from residential exposures was $405 million (95% CI: $264 -$547 million) annually.Conclusions. 4 -20 Studies that have implicated certain risk factors for asthma, however, are often limited by small sample size or a restricted focus on a specific age group, geographic distribution, or socioeconomic strata. 4,10,17,21 Thus, the relative contribution of specific allergens or other residential exposures to asthma for children and adolescents in the United States is poorly defined. Moreover, there has not been any attempt to estimate the overall contribution of indoor allergens or residential exposures to asthma. To develop a national strategy to prevent childhood asthma, it is critical to estimate the contribution of specific risk factors and the overall contribution of residential exposures to asthma.In a previous analysis, we estimated that residential exposures-including pets in the household, allergy to a pet, exposure to environmental tobacco smoke, and use of gas stove or oven for heat-accounted for 530 000 excess cases (40%) of doctordiagnosed asthma in children Ͻ6 years old. 20 Risk factors for asthma in early childhood, however, are often distinct from those that predict asthma in later childhood and adolescence. 6,9 Moreover, skin testing was not conducted among ch...

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Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma

Cited by 305 publications

References 25 publications

Exposure to Alternaria alternata in US homes is associated with asthma symptoms

Exposure to Alternaria alternata in US homes is associated with asthma symptoms

Are Building-Level Characteristics Associated with Indoor Allergens in the Household?

Contribution of Residential Exposures to Asthma in US Children and Adolescents

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