Relationship of High Sensitivity C-Reactive Protein Levels to Anthropometric and other Metabolic Parameters in Indian Children with Simple Overweight and Obesity

Abstract

Context: High senstivity C-reactive protein (hsCRP) levels correlate well other parameters of obesity related metabolic syndrome (MS) and can be used as predictors of future cardiovascular disease risk. There is limited data on hsCRP levels in Indian children with simple obesity. Aim:To study the relationship of hsCRP levels with various anthropometric as well as metabolic parameters in children with simple overweight and obesity. Materials and Methods:This case control study was conducted in Paediatric Endocrinology clinic of a tertiary care hospital in Northern India. Levels of hsCRP were estimated in 100 overweight and obese children (BMI between 85 th and 95 th percentiles according to age & gender specific CDC 2000 growth charts) aged between 6 and 16 years and in 100 nearly age and sex matched healthy controls. These levels were then correlated to various anthropometric (body mass index, BMI; waist circumference, WC; hip circumference, HC; waist hip ratio, WHR; blood pressure) and biochemical (fasting blood glucose, FBG; total cholesterol, TC; high-density lipoproteincholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; very low-density lipoprotein-cholesterol, VLDL-C; triglycerides, TG) parameters.Results: Mean levels of hsCRP were significantly higher in the study group (3.92±2.20 versus 2.15±1.05 mg/L) as compared to controls. Significantly more (58% versus 10%) subjects in the study group had hsCRP (>3 mg/L). Of all the parameters studied, only BMI showed a positive correlation with hsCRP levels in the study group. Multiple logistic regression analysis for predicting outcome of high hsCRP showed positive correlation with BMI; with every 1 kg/m 2 increase in BMI, odds of high hsCRP level were increased by 37% (OR=1.37; 95% CI 1.23-1.53, p-value <0.0001). Mean values of all the biochemical parameters except HDL-C were significantly higher in the study group.Conclusion: Levels of hsCRP were significantly elevated in overweight and obese children as compared to non-obese children. In addition, these patients also showed abnormalities of lipid and glucose metabolism.

Subtle inflammation: a possible mechanism of future cardiovascular risk in obese children

“…Our results were in alignment with previous studies, demonstrating that obese children had elevated inflammatory markers, for instance hs-CRP 8 25 26 27 28 29 30 31 32) , TNF-α 26 27 29 33) , and IL-6 26 , 28 , 34) . Compared to the study done by El-shorbagy and Ghoname 25) demonstrating a prevalence of hs-CRP>3 mg/L of 35%, our study showed as much as twice higher prevalence.…”

Predictors of Inflammation in a Cohort of Bolivian Infants and Toddlers

“…Neither marker of anthropometry (stunting nor overweight, both at low-to-moderate levels in the population) was significantly associated with inflammation in this cohort. Although an association of adiposity and inflammation has been well established in adults, 19,20,24,41 and other authors have found similar associations in children, 17,20,[42][43][44][45][46][47][48][49][50][51][52] we did not see a significant association of WLZ with inflammation in our cohort. Alternative definitions of adiposity (using body mass index-for-age Z-score as well as cutoffs for obesity versus normal-overweight) also failed to yield significant results in our models, suggesting that differences in adiposity definition were not the explanation for our results.…”

Levothyroxine supplementation for obesity-associated thyroid dysfunction in children: a prospective, randomized, case control study

“…Simple obesity (SO) in children is associated with several metabolic and hormonal disturbances which contribute to the risk of developing chronic lifestyle-related diseases in later life [1,2]. While the metabolic problems occur due to the excess of adipose tissue that works as an endocrine organ, the hormonal disturbances are attributed to the changes in the plasma concentrations, secretory patterns and clearance of various hormones in SO [3].…”