Relationship of Hepatic and Renal Dysfunction With Haemorrheological Parameters in Plasmodium Falciparum Malaria

Prasad, Valluri Satya; Subrahmanyam, M. V. R.

doi:10.18410/jebmh/2015/393

Cited by 1 publication

(4 citation statements)

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“…Our observation regarding such haemorrheological abnormalities in subjects with falciparum malaria having hepatopathy and ARF are comparable with publications by other investigators on this subject, like Misra DP et al and Prasad VS et al 4,5,7 Thrombocytopenia may be a cause of marked bleeding diathesis in falciparum malaria.…”

Section: Discussionsupporting

confidence: 92%

“…In group A of our studies haemoglobin was negatively correlate with serum urea (r = -0.584 ; p <0.05), serum creatinine (r = -0.5942 ;p<0.05),serum bilirubin ( r =-0.5865 ;p<0.05), AST (r = -0.4919 ; p<0.05), ALT ( r = -6779; p<0.05), ALP (r = -0.7408; p<0.05). This correlation is found in studies of Misra DP et al, Prasad S et al and Balaraju et al5,6 Platelet negatively correlate with serum urea (r =-0.589; p <0.05), serum creatinine (r= -0.7327; p <0.05), bilirubin (r = -0.6538; p <0.05), AST (r = -0.5712; p <0.05), ALT (r = -0.4992 ;p <0.05), ALP(r = -0.6898; p <0.05). This correlation is found in studies of Balaraju G et al, Prasad VS et al5,6 BT positively correlate with serum urea, serum creatinine, bilirubin, AST, ALT, ALP similarly correlate with the studies of Balaraju G et al6 CT positively correlates with all renal and hepatic parameters.…”

supporting

confidence: 74%

“…This correlation is found in studies of Misra DP et al, Prasad S et al and Balaraju et al5,6 Platelet negatively correlate with serum urea (r =-0.589; p <0.05), serum creatinine (r= -0.7327; p <0.05), bilirubin (r = -0.6538; p <0.05), AST (r = -0.5712; p <0.05), ALT (r = -0.4992 ;p <0.05), ALP(r = -0.6898; p <0.05). This correlation is found in studies of Balaraju G et al, Prasad VS et al5,6 BT positively correlate with serum urea, serum creatinine, bilirubin, AST, ALT, ALP similarly correlate with the studies of Balaraju G et al6 CT positively correlates with all renal and hepatic parameters. PT with INR positively correlates with all renal and hepatic parametes.…”

supporting

confidence: 74%

“…Prasad VS et al in his study observe hepatomegaly in 52% cases and splenomegaly in 44% cases. 5 In our study overt bleeding was a rare manifestation, observe only 1 (3.33%) cases of complicated falciparum malaria and no cases observe in uncomplicated falciparum malaria. Balaraju G et al also observe overt bleeding in only 3.33% of cases.…”

Section: Discussionmentioning

confidence: 41%

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Observation on relationship of hepatic and renal dysfunction with haemorrheological parameters in plasmodium falciparum malaria in Kosi region, Bihar, India

Rahman¹,

Agrawal²

2017

Int J Adv Med

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Background: Malaria contribute to be one of the major public health problem in around 1.5 million contribute per year, of which about 52% due to Plasmodium falciparum. The study was designed to assess hepatic and renal dysfunction in plasmodium falciparum malaria, and evaluate if such abnormalities had any bearing with the haemorrheological dysfunction. Methods: Group A comprising 30 cases of plasmodium falciparum positive cases with jaundice or renal failure or both and Group B Comprising 30 cases of falciparum malaria and have no complication. Laboratory investigation was done for liver and renal function test, complete blood count and coagulation profile. The data collected was analysed to inter-correlate parameters of hepatic, renal and haemorrheological dysfunction. Results: Fever was the predominant feature in our study, present in 100% patient followed by chill and rigors which was present in 90% cases of both groups. Hepatomegaly was present in 53.33% cases in group A and 16.67% in group B, whereas spleenomegaly was present in 43.33% cases in group A and 26.67% in group B. Most common complication in group A was jaundice present in 100% cases followed by renal failure present in 53.33% cases. Overt bleeding was present in only 3.33% cases with complicated falciparum malaria. Anemia was present in 73.33% cases of group A and 50% cases in group B. Thrombocytopenia was present in 50% patient in group A and 23.33% in group B. Bleeding time, clotting time, PT with INR, APTT, FDP and LDH was much higher in group A than group B in our study. The biochemical parameters (serum urea, creatinine, bilirubin, AST, ALT, ALP) in both groups differed significantly. In group A Haemoglobin and platelet count significantly negatively correlated with hepatic and renal parameters where as FDP and LDH significantly positively correlated with all the hepatic and renal parameters. In group B the correlation between hematological and biochemical (hepatic and renal) parameters was not found to be statistically significant. Conclusions: Patients of complicated falciparum malaria have significant subclinical haemorrheological disorders even if they do not manifest as clinically overt DIC.

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Section: Discussionsupporting

confidence: 92%

supporting

confidence: 74%

supporting

confidence: 74%

Section: Discussionmentioning

confidence: 41%

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