Relationship of GnRH‐stimulated LH release to episodic LH secretion and baseline endocrine‐metabolic measures in women with polycystic ovary syndrome

Abstract

These results indicate that the absolute LH increment following GnRH is largely dependent on baseline LH levels and may account for the well-documented difference in LH responsiveness between PCOS and normal women. That neither LH responses to GnRH nor LH pulse amplitude were correlated to LH pulse frequency suggests involvement of other factors along with GnRH to account for increased LH secretion in PCOS. In addition to E2 and BMI, serum testosterone appears to be, at least in part, responsible for differences in LH secretion and release between PCOS and normal women.

Effect of Polycystic Ovary Syndrome and Hormones Disorder on Enzymes Gammaglutamyl Transferase, Oxaloacetic Transaminase, and Proteins

“…Increase LH levels, cause observed some abnormality in the function of hypothalamic neurotransmitter. Lutinzing hormone secretion and an increased ratio of serum Lutinzing hormone to follicle stimulating hormone (LH/FSH) during the menstrual cycle follicular phase has been considered as PCOS marker [39]. In our result the ratio of serum LH/FSH was increased to 2.07 in comparing with normal healthy women 1.07, the patients with PCOS often have change functions of hypothalamopituitary, including increased baseline LH concentrations and elevated LH/FSH ratios, as previously reported [39].…”

“…In PCOS patients the potential iron overload is contributed to factors that involve the effect of iron sparing of chronic dysfunction of menstrual, decrease in hepcidin hormone, insulin resistance, this leading to increased iron absorption [38]. Increasing of iron store though that it is contributed to hyperinsulinism and deposition of iron in β cell through the reduction of hepatic insulin extraction and metabolism, this indicate that tissue does not become circulated and extracted easily [39]. Oligomenorrhea and less blood loss in PCOS subjects might be the best explanation for their increased highly serum ferritin levels, indicating increased stores iron of body, in obese women with PCOS.…”

“…Lutinzing hormone secretion and an increased ratio of serum Lutinzing hormone to follicle stimulating hormone (LH/FSH) during the menstrual cycle follicular phase has been considered as PCOS marker [39]. In our result the ratio of serum LH/FSH was increased to 2.07 in comparing with normal healthy women 1.07, the patients with PCOS often have change functions of hypothalamopituitary, including increased baseline LH concentrations and elevated LH/FSH ratios, as previously reported [39]. It was reporting that fat disturbance and obesity plays a crucial role in the pathophysiology of hyperandrogenism and abnormalities in metabolism of PCOS and, because of capability of synthesis active androgen in human adipose tissue [44].…”

Prenatal Exposure of Kisspeptin Antagonist on the GonadotropinReleasing Hormone (GnRH) Expression in Rat Model of Polycystic Ovary Syndrome

“…These animals exhibit elevated LH pulse frequency and irregular reproductive cycles, which may result from a number of mechanisms, including alterations in synaptic input to GnRH neurons, 2004, desensitization of GnRH neurons to steroid feedback, increased amplitude/frequency of GnRH pulses, and increased gonadotropic sensitivity to the GnRH stimulation [20][21][22][23][24]. Kisspeptin, an essential gatekeeper of puberty onset and GnRH secretion, mediates steroid feedback and metabolic cues during different developmental stages throughout the lifespan [9,25].…”

Ο ωοθηκικός έλεγχος της υποφυσιακής ευαισθησίας στη GnRH στις γυναίκες με PCOS

“…Τα επίπεδα της LH είναι αυξηµένα στην πλειοψηφία των γυναικών µε PCOS (Balen et al, 1996;Hendrics et al, 2008). Επίσης η απαντητικότητα της υπόφυσης στη GnRH είναι αυξηµένη στις γυναίκες µε PCOS (Mortimer et al, 1978;Steck et al, 1991;Patel et al, 2004). Εάν αυτή η υπερευαισθησία της υπόφυσης στη GnRH όσον αφορά την έκκριση της LH, οφείλεται σε ωοθηκικούς παράγοντες ή σε δυσλειτουργία της υπόφυσης είναι αντικείµενο συζητήσεων και έρευνας (Ehrmann 2005).…”