Relationship of frailty with treatment modality selection in patients with muscle-invasive bladder cancer (FRART-BC study)

Iwamura, Hiromichi; Hatakeyama, Shingo; Momota, Masaki; Kojima, Yuta; Narita, Takuma; Okamoto, Teppei; Fujita, Naoki; Hamano, Itsuto; Togashi, Kyou; Hamaya, Tomoko; Yoneyama, T.; Yamamoto, Hayato; Yoneyama, Takahiro; Hashimoto, Yasuhiro; Οhyama, Chikara

doi:10.21037/tau-20-1351

Cited by 7 publications

(5 citation statements)

References 30 publications

(41 reference statements)

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“…Thus, the development of frailty‐based treatment strategies is urgently needed for older patients. Previous studies showed that frailty was associated with the treatment modality selection, type of urinary diversion, and adverse postoperative outcomes 22–24 . In addition, frailty was associated with an increased odds of delayed GI function recovery or the rate of POI or anastomotic leakage in patients who underwent elective colorectal cancer resections.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies showed that frailty was associated with the treatment modality selection, type of urinary diversion, and adverse postoperative outcomes. [22][23][24] In addition, frailty was associated with an increased odds of delayed GI function recovery or the rate of POI or anastomotic leakage in patients who underwent elective colorectal cancer resections. These findings suggest that there is an association between frailty and the delayed bowel function or POI.…”

Section: Discussionmentioning

confidence: 99%

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Risk factors for postoperative ileus after robot‐assisted radical cystectomy with intracorporeal urinary diversion

et al. 2022

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Abbreviations & Acronyms ASA = American Society of Anesthesiologists BMI = body mass index CRP = C-reactive protein EBL = estimated blood loss ECUD = extracorporeal urinary diversion ERAS = enhanced recovery after surgery G-8 = Geriatric-8 GI = gastrointestinal ICUD = intracorporeal urinary diversion IQR = interquartile range iRARC = RARC with ICUD LOS = length of hospital stay MIBC = muscle invasive bladder cancer NAC = neoadjuvant chemotherapy NMIBC = nonmuscle invasive bladder cancer POI = postoperative ileus RARC = robot-assisted radical cystectomy RC = radical cystectomy ROC = receiver operating characteristic WBC = white blood cells

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Risk factors for postoperative ileus after robot‐assisted radical cystectomy with intracorporeal urinary diversion

et al. 2022

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“…A recent study suggested that frailty plays a key role in modality selection (radical cystectomy or radiotherapy) 26 and urinary diversion selection (ileal neobladder or others) 27 . However, the clinical application of a comprehensive geriatric assessment is not easy because of its complexity and time‐consuming nature 15,18–20 .…”

Section: Discussionmentioning

confidence: 99%

Trends in the age of hospitalized patients with urological cancers: A 17‐year experience

et al. 2023

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Objectives To investigate the impact of global aging on the trends in the age of hospitalized patients with a urological cancer diagnosis. Methods We retrospectively evaluated a cumulative total of 10 652 cases of referred patients (n = 6637) with a urological disease who were hospitalized in our institution between January 2005 and December 2021. We compared age and the proportion of patients aged ≥80 years among patients who were hospitalized in the urological ward between the period of 2005–2013 and that of 2014–2021. Results We identified 8168 hospitalized patients with urological cancer. The median age was significantly increased in patients with urological cancer between the periods of 2005–2013 and 2014–2021. The proportion of hospitalized patients with urological cancer aged ≥80 years was significantly increased between the periods of 2005–2013 (9.3%) and 2014–2021 (13.8%). The median ages of the patients with urothelial cancer (UC) and renal cell carcinoma (RCC), but not the median age of those with prostate cancer (PC), were significantly increased between the study periods. The proportion of hospitalized patients with UC, but not the proportions of those with PC and RCC, aged ≥80 years was significantly increased between the study periods. Conclusions The age of patients with urological cancer who were hospitalized in the urological ward and the proportion of patients with UC aged ≥80 years significantly increased over the entire study period.

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“…Frailty assessment in elderly patients with cancers is important in managing the balance between harms and benefits [ 23 , 24 , 25 , 26 , 27 , 28 ]. However, a full geriatric assessment in all candidates is time-consuming and is not feasible in clinical practice [ 10 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Utility of the Age Discrepancy between Frailty-Based Biological Age and Expected Life Age in Patients with Urological Cancers

Togashi

Sato

Okita

et al. 2022

Cancers

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Background: The estimation of biological age is challenging in patients with cancers. We aimed to investigate frailty-based biological ages using frailty-discriminant scores (FDS) and examined the effect of biological-expected life age discrepancy on the prognosis of patients with urological cancers. Methods: We retrospectively evaluated frailty in 1035 patients having urological cancers. Their frailty-based biological age was then defined by the FDS, which is a comprehensive frailty assessment tool, using 1790 noncancer individuals as controls. An expected life age (=chronological age + life expectancy) was subsequently calculated using the 2019 life expectancy table. The primary outcome was the estimation of the biological-expected life age discrepancy between the frailty-based biological age and expected life age in patients with urological cancers. Secondary outcomes were the evaluation of the effect of the biological-expected life age discrepancy on overall survival. Results: We included 405, 466, and 164 patients diagnosed with prostate cancer, urothelial carcinoma, and renal cell carcinoma, respectively. The median chronological age, life expectancy, and estimated frailty-based biological age were 71, 17, and 83 years, respectively. The biological-expected life age discrepancy in any urological cancers, localized diseases, and metastatic diseases was −4.8, −6.3, and +0.15 years, respectively. The biological-expected life age discrepancy of >5 years was significantly associated with poor overall survival. Conclusions: The biological-expected life age discrepancy between frailty-based biological age and expected life age may be helpful in understanding the role of frailty and patient/doctor conversation.

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Relationship of frailty with treatment modality selection in patients with muscle-invasive bladder cancer (FRART-BC study)

Cited by 7 publications

References 30 publications

Risk factors for postoperative ileus after robot‐assisted radical cystectomy with intracorporeal urinary diversion

Risk factors for postoperative ileus after robot‐assisted radical cystectomy with intracorporeal urinary diversion

Trends in the age of hospitalized patients with urological cancers: A 17‐year experience

Utility of the Age Discrepancy between Frailty-Based Biological Age and Expected Life Age in Patients with Urological Cancers

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