Relationship of follicle numbers and estradiol levels to multiple implantation in 3,608 intrauterine insemination cycles

Dickey, Richard P.; Taylor, Steven N.; Lu, Peter Y.; Sartor, Belinda M.; Rye, Phillip H.; Pyrzak, Roman

doi:10.1016/s0015-0282(00)01631-9

Cited by 90 publications

(59 citation statements)

References 37 publications

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“…During ovarian stimulation (ovulation induction or ovarian hyperstimulation) it has been shown that the number of follicles measuring 12 mm or more at the day of hCG administration is strongly correlated with the incidence of high order multiple pregnancies (37,38). Similarly, E 2 serum concentrations are strongly correlated with adverse outcome (38).…”

Section: Discussionmentioning

confidence: 99%

Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women

Laven¹,

Jong²,

Fauser³

2005

eur j endocrinol

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Objective: To investigate the relationship between serum concentrations of inhibin A, inhibin B and estradiol (E 2 ) and the number of developing follicles during the administration of exogenous follicle-stimulating hormone (FSH) in various regimens in normo-ovulatory volunteers and to evaluate if inhibins act as suitable markers for the number of developing follicles during ovarian stimulation. Design and methods: Serial hormone determinations and assessment of follicle numbers were carried out during unstimulated cycles and during various interventions with exogenous FSH. Subjects were randomized for FSH administration into the following groups: a single high dose (375 IU) during the early follicular phase (group A), 5 consecutive low doses (75 IU/day) starting in the mid follicular phase (group B) or daily low doses (75 IU/day) during the early to late follicular phase (starting on cycle days 3, 5 or 7; groups C, D and E respectively). Results: Extending the FSH window increases the number of small antral follicles and hence inhibin B serum concentrations. If such an intervention results in multi-follicular growth, mid follicular phase inhibin B (P ¼ 0.001) as well as late follicular phase inhibin B and inhibin A levels are significantly (P , 0.05 and P , 0.01 respectively) increased compared with mono-follicular cycles or the natural cycle. Although mid follicular inhibin B levels correlated well with the number of small antral (P , 0.05) and pre-ovulatory (P , 0.001) follicles in the late follicular phase, mid follicular inhibin A and estradiol serum concentrations only correlated with the number of pre-ovulatory follicles (P , 0.001 and P , 0.01 respectively). Conclusions: The present data extend our understanding of the relationship between follicle dynamics, serum inhibins and FSH during ovarian hyperstimulation. However, although mid follicular inhibin B does correlate with the number of developing follicles, it does not facilitate the identification of women at risk for multiple follicle development.European Journal of Endocrinology 152 395-401

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Section: Discussionmentioning

confidence: 99%

Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women

Laven¹,

Jong²,

Fauser³

2005

eur j endocrinol

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“…Also, raising children in this phase of life may be hampered by decreasing physical fitness and mental flexibility. Research on this topic, however, is scarce [38]. Finally, survival statistics on men and women will show a considerable increase in the rate of mortality between the ages of 40 and 60 years.…”

Section: Assessment Of Age Limits For Artmentioning

confidence: 99%

Female Age in ART: When to Stop?

Broekmans¹,

Klinkert²

2004

Gynecol Obstet Invest

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With increasing age the probability of ongoing pregnancy established by the use of assisted reproduction technology (ART) decreases. As a result the question arises whether age limits for the application of ART should be established. From a literature review and ongoing research data it appears that the costs per child born greatly increase after the age of 40 for both intrauterine insemination with mild ovarian stimulation and in vitro fertilisation treatment, while in cases of 44 and over, prognosis is flat zero. The willingness to pay for extra costs will greatly determine whether and at what age strict limits should be applied. Fortunately, predictive factors for success, like the antral follicle count, may enable the identification of women over 40 and under 44 that still have favourable prospects, thereby decreasing the necessary costs per childbirth and allowing couples into ART programs that are often denied based solely on female age.

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“…25.1a. For CC-IUI, pregnancy rates per cycle declined slowly from < 28 to 41 years of age, and then more rapidly by 50 % from age 42 to 44 [23]. Compared to CC-IUI, pregnancy rates per cycle were twice as high before age 32, for COH-IUI (human menopausal gonadotropin (hMG) IUI) and for CC + hMG − IUI (CC for 5 days followed by hMG for 3-4 days) but declined sharply thereafter and were identical to pregnancy rates for CC-IUI after age 37.…”

Section: Agementioning

confidence: 99%

Clomiphene Citrate for Women with Unexplained Infertility

Dickey

2015

Unexplained Infertility

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Relationship of follicle numbers and estradiol levels to multiple implantation in 3,608 intrauterine insemination cycles

Cited by 90 publications

References 37 publications

Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women

Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women

Female Age in ART: When to Stop?

Clomiphene Citrate for Women with Unexplained Infertility

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