Relationship of fish and cod oil intake with adult asthma

Lærum, Birger Norderud; Wentzel‐Larsen, Tore; Gulsvik, Amund; Omenaas, Ernst; Gíslason, Þórarinn; Janson, Christer; Svanes, Cecilie

doi:10.1111/j.1365-2222.2007.02821.x

Cited by 45 publications

(36 citation statements)

References 27 publications

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“…Fish in the diet is a source of n-3 fatty acids, which may compete with the pro-inflammatory properties of n-6 fatty acids (30,31) . Recent results from the Respiratory Health in Northern Europe study indicated that infrequent fish intake was associated with increased asthma symptoms (32) , but experimental support for this as a major influence on clinical disease is still weak (33) . Dietary antioxidants, of which fruits and vegetables should be a rich source, have also been hypothesised to be important in protecting against atopic disease (34) .…”

Section: Discussionmentioning

confidence: 99%

Dietary patterns and risk of asthma: results from three countries in European Community Respiratory Health Survey-II

et al. 2009

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Dietary patterns offer an alternative to the analysis of individual foods or nutrients in nutritional epidemiological studies. The aim of the present study was to identify dietary patterns common to different European countries and examine their associations with asthma. In five study centres (two in Germany, two in the UK and one in Norway), 1174 adults aged 29–55 years completed a FFQ and respiratory symptoms questionnaire. A meta-analytic approach was used to identify the dietary patterns and analyse them in relation to current asthma, asthma symptoms and bronchial responsiveness (BHR). Two patterns emerged, generally correlating with the same foods at different centres: one associated with intake of meats and potatoes; the other with fish, fruits and vegetables. There was no evidence that the fish, fruits and vegetables pattern was associated with asthma (OR 1·11 (95 % CI 0·93, 1·33)), symptom score (ratio of means 1·07 (0·98, 1·17)) or BHR (regression coefficient − 0·01 ( − 0·12, 0·10)), though these CI appeared to rule out large protective effects of consuming these foods. There was no overall evidence that the meat and potato pattern was associated with asthma (OR 1·02 (0·79, 1·31)), symptom score (ratio of means 1·07 (0·84, 1·36)) or BHR (regression coefficient − 0·08 ( − 0·27, 0·10)), but there was heterogeneity between centres in the association with symptom score: a negative association at the two German centres; a positive association at the others. Heterogeneity in a multi-centre observational study of diet could suggest alternative explanations for apparent effects of diet, such as uncontrolled confounding.

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Section: Discussionmentioning

confidence: 99%

Dietary patterns and risk of asthma: results from three countries in European Community Respiratory Health Survey-II

et al. 2009

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“…Marine omega-3 polyunsaturated fatty acids have been found to be a protective factor for telomere length shortening in a cohort of individuals with coronary artery disease (FarzanehFar et al, 2010). Since the cohort in this study is based on Norwegians, who in general has a much higher fish intake than many other European populations (Engeset et al, 2006;Laerum et al, 2007), marine fatty acids may have modified the effect of smoking or other types of genotoxic exposures on telomere length. Also there is increasing evidence that the diet influences the DNA methylation (Arasaradnam et al, 2008;Zeisel, 2011).…”

Section: Discussionmentioning

confidence: 99%

Telomere length and LINE1 methylation is associated with chromosomal aberrations in peripheral blood

Hilmarsen

Hossain

et al. 2012

Genes Chromosomes & Cancer

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The frequency of chromosomal aberrations in peripheral blood predicts a probable cancer risk. The individual telomere length and methylation of repetitive elements may be susceptibility factors for chromosomal aberrations. A cohort of healthy Norwegian men (N ¼ 364) recruited during 1980-1999 were analyzed for chromosomal aberrations in phytohemagglutinin-stimulated lymphocytes from peripheral blood. Chromosome-type or chromatid-type aberrations were scored. DNA was extracted from slides cytogenetically analyzed and relative average telomere length and methylation of LINE1 repeats were determined by quantitative polymerase chain reaction and bisulfite pyrosequencing, respectively. Information about individuals with malignant tumors (N ¼ 49) diagnosed after chromosomal aberrations testing until end of 2008 was obtained and two matched controls per case were used in a nested case-control analysis. Shorter relative telomere length and higher methylation of LINE1 were associated with higher frequency of total chromosomal aberrations (b ¼ À0.76, P ¼ 0.022; and b ¼ 0.042, P ¼ 0.048, respectively; age-adjusted ordinal regression). The telomere length was stronger associated with chromosome-type (b ¼ À1.00, P ¼ 0.006) than with chromatid-type aberrations (b ¼ À0.49, P ¼ 0.115). The LINE1 methylation was stronger associated with chromatid-type (b ¼ 0.062, P ¼ 0.003) than with chromosome-type aberrations (b ¼ 0.018, P ¼ 0.41). Telomere length [individuals with short telomeres odds ratio (OR) ¼ 0.87, 95% confidence interval (CI) 0.38-2.0], LINE1 (individuals with high methylation OR ¼ 1.04, 95% CI 0.43-2.5) and chromosomal aberrations (individuals with high frequency OR ¼ 1.6, 95% CI 0.63-3.9) at baseline did not predict cancer risk, but the conclusions were hampered by low statistical precision. The results suggest that shorter telomere length and higher LINE1 methylation in peripheral blood lymphocytes are predisposition factors for increased frequency of chromosomal aberrations.

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“…However, although some authors report an association between the intake of lipids, certain fatty acids and certain foods and asthma (Bolte et al, 2005;Laerum et al, 2007;Olsen et al, 2008), others have found none (Devereux and Seaton, 2005;Almqvist et al, 2007;Kim et al, 2009;de Vries and Howie, 2009). Nevertheless, because of the fact that saturated fatty acids (SFAs) intake among children is very high nowadays, reaching the double of the recommended intake in some cases (Royo-Bordonada et al, 2006;McNeill et al, 2010), SFAs intake could be related to the increase in the prevalence of asthma.…”

Section: Introductionmentioning

confidence: 99%

Fat intake and asthma in Spanish schoolchildren

et al. 2010

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Objectives: To study the relationship between lipid, fatty acid and lipid-rich food intake and current asthma in a group of Spanish schoolchildren. Subjects/Methods: The subjects of this cross-sectional study were 638 Spanish schoolchildren (8-13 years of age). The weight and height of all the subjects were recorded. A questionnaire, completed by the subjects' parents, was used to obtain personal and health information. Current asthma was established when the children had ever had asthma, if they had been diagnosed with asthma by a doctor and if they had been treated with medications at some time in the previous 12 months. Food intake was monitored using a 3-day food record. All foods consumed were converted into energy and nutrients. Results: The energy derived from lipids, saturated fatty acids (SFAs) and myristic and palmitic acids was independently associated with current asthma (Odds Ratio (OR) third tertile 2.85 (1.01-8.07) P ¼ 0.049, 10.00 (0.89-111.97) P ¼ 0.002, 11.21 (1.36-92.24) P ¼ 0.002, 7.58 (1.40-41.03) P ¼ 0.022, respectively), as was the intake of butter (OR third tertile 2.97 (1.01-8.68) P ¼ 0.001). No relationship was seen between this condition and the intake of any other fatty acid, the n-6/n-3 ratio, nor the consumption of margarine, milk products, fish, meat, eggs or vegetable oils. Conclusions: Increased intakes of SFAs, myristic and palmitic acids and butter seem to be related to the risk of current asthma in children.

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Relationship of fish and cod oil intake with adult asthma

Cited by 45 publications

References 27 publications

Dietary patterns and risk of asthma: results from three countries in European Community Respiratory Health Survey-II

Dietary patterns and risk of asthma: results from three countries in European Community Respiratory Health Survey-II

Telomere length and LINE1 methylation is associated with chromosomal aberrations in peripheral blood

Fat intake and asthma in Spanish schoolchildren

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