Relationship of Fibronectin and CD44v6 Expression with Invasive Growth and Metastasis of Liver Cancer

Jha, Rajiv Kumar; Ma, Qingyong; Chen, Shahuan; Sha, Huanchen; Ding, Shanshan

doi:10.1080/07357900802375753

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Collagen IV interacts with different cell surface receptors involved in various intracellular signaling pathways to promote tumor cell proliferation and migration as well as tumor angiogenesis [ 36 ]. FN, a potential diagnostic marker of liver cancer invasion and metastasis, participates in forming the cytoskeleton and in determining cell morphology [ 37 ]. LN and its related proteins play an important role in maintaining the normal function of the basement membrane, which is involved in cell growth, differentiation, migration, and adsorption [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice

Song

Zhaoxia

et al. 2016

Nutrients

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Inositol hexaphosphate (IP6) and inositol (Ins), naturally occurring carbohydrates present in most mammals and plants, inhibit the growth of numerous cancers both in vitro and in vivo. In this study, we first examined the anti-metastatic effects of IP6 and Ins using a liver metastasis model of colorectal cancer (CRC) in BALB/c mice. CT-26 cells were injected into the splenic capsule of 48 BALB/c mice. The mice were then randomly divided into four groups: IP6, Ins, IP6 + Ins and normal saline control (n = 12 per group). IP6 and/or Ins (80 mg/kg each, 0.2 mL/day) were injected into the gastrointestinal tracts of the mice on the second day after surgery. All mice were sacrificed after 20 days, and the tumor inhibition rates were determined. The results demonstrated that the tumor weights of liver metastases and the tumor inhibition rates were reduced in the experimental groups compared to the control group and that treatment with the combination of IP6 and Ins resulted in greater inhibition of tumor growth than treatment with either compound alone. These findings suggest that IP6 and Ins prevent the development and metastatic progression of colorectal cancer to the liver in mice by altering expression of the extracellular matrix proteins collagen IV, fibronectin and laminin; the adhesion factor receptor integrin-β1; the proteolytic enzyme matrix metalloproteinase 9; and the angiogenic factors vascular endothelial growth factor, basic fibroblast growth factor, and transforming growth factor beta in the tumor metastasis microenvironment. In conclusion, IP6 and Ins inhibited the development and metastatic progression of colorectal cancer to the liver in BALB/c mice, and the effect of their combined application was significantly greater than the effect of either compound alone. This evidence supports further testing of the combined application of IP6 and Ins for the prevention of colorectal cancer metastasis to the liver in clinical studies.

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Section: Discussionmentioning

confidence: 99%

Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice

Song

Zhaoxia

et al. 2016

Nutrients

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“…Tumour cells with high expression of FN on the cell surface can enhance the adhesion of tumour cells to each other and the anchoring adhesion ability of cells to matrix and basal membrane without shedding and metastasis through the action of various adhesion molecules on the cell membrane surface. 15 We examined fibronectin expression in vector and ANKRD49 OE groups by immunohistochemistry (Figure 3D,E ). We found that ANKRD49 overexpression increased the immunoreactivities of FN.…”

Section: Resultsmentioning

confidence: 99%

ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF‐2 signalling pathway

Liu

Yuan

et al. 2022

J Cellular Molecular Medi

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Lung adenocarcinoma (LUAD) is the most challenging neoplasm to treat in clinical practice. Ankyrin repeat domain 49 protein (ANKRD49) is highly expressed in several carcinomas; however, its pattern of expression and role in LUAD are not known. Tissue microarrays, immunohistochemistry, χ 2 test, Spearman correlation analysis, Kaplan–Meier, log‐rank test, and Cox's proportional hazard model were used to analyse the clinical cases. The effect of ANKRD49 on the LUAD was investigated using CCK‐8, clonal formation, would healing, transwell assays, and nude mice experiment. Expressions of ANKRD49 and its associated downstream protein molecules were verified by real‐time PCR, Western blot, immunohistochemistry, and/or immunofluorescence analyses. ANKRD49 expression was highly elevated in LUAD. The survival rate and Cox's modelling analysis indicated that there may be an independent prognostic indicator for LUAD patients. We also found that ANKRD49 promoted the invasion and migration in both in in vitro and in vivo assays, through upregulating matrix metalloproteinase (MMP)‐2 and MMP‐9 activities via the P38/ATF‐2 signalling pathway Our findings suggest that ANKRD49 is a latent biomarker for evaluating LUAD prognosis and promotes the metastasis of A549 cells via upregulation of MMP‐2 and MMP‐9 in a P38/ATF‐2 pathway‐dependent manner.

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“…In this way, CD44v6 has been described to negatively impact the prognosis of patients with multiple myeloma ( 19 ), colorectal cancer (CRC) ( 20 , 21 ), osteosarcoma ( 22 ), esophageal carcinoma ( 22 ), gastric cancer ( 23 ) as well as head and neck squamous cell carcinoma (HNSCC) ( 24 , 25 ) patients, among others. Moreover, altered CD44v6 expression has been associated with tumor development, migration, invasion and metastatic potential in a broad variety of tumor types, such as HNSCC ( 24 ), oral cancer ( 26 ), laryngeal carcinoma ( 27 ), esophageal squamous cell carcinoma, gastric cancer ( 28 – 30 ), pancreatic cancer ( 11 , 31 ), liver cancer ( 32 , 33 ), CRC ( 34 ), lung cancer ( 35 , 36 ), breast carcinoma ( 37 ) and gynecologic malignancies ( 38 ) such as ovarian ( 39 , 40 ) and prostate cancer ( 41 ), among others ( Figure 1 ).…”

Section: Cd44 Alternative Splicing As a Source Of Taasmentioning

confidence: 99%

CD44v6, STn & O-GD2: promising tumor associated antigens paving the way for new targeted cancer therapies

Lodewijk,

Dueñas,

Paramio

et al. 2023

Front. Immunol.

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Targeted therapies are the state of the art in oncology today, and every year new Tumor-associated antigens (TAAs) are developed for preclinical research and clinical trials, but few of them really change the therapeutic scenario. Difficulties, either to find antigens that are solely expressed in tumors or the generation of good binders to these antigens, represent a major bottleneck. Specialized cellular mechanisms, such as differential splicing and glycosylation processes, are a good source of neo-antigen expression. Changes in these processes generate surface proteins that, instead of showing decreased or increased antigen expression driven by enhanced mRNA processing, are aberrant in nature and therefore more specific targets to elicit a precise anti-tumor therapy. Here, we present promising TAAs demonstrated to be potential targets for cancer monitoring, targeted therapy and the generation of new immunotherapy tools, such as recombinant antibodies and chimeric antigen receptor (CAR) T cell (CAR-T) or Chimeric Antigen Receptor-Engineered Natural Killer (CAR-NK) for specific tumor killing, in a wide variety of tumor types. Specifically, this review is a detailed update on TAAs CD44v6, STn and O-GD2, describing their origin as well as their current and potential use as disease biomarker and therapeutic target in a diversity of tumor types.

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Relationship of Fibronectin and CD44v6 Expression with Invasive Growth and Metastasis of Liver Cancer

Cited by 7 publications

References 16 publications

Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice

Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice

ANKRD49 promotes the invasion and metastasis of lung adenocarcinoma via a P38/ATF‐2 signalling pathway

CD44v6, STn & O-GD2: promising tumor associated antigens paving the way for new targeted cancer therapies

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