Relationship of Fibrinolytic System to Postoperative Thrombotic Phenomena

Fibrinolysis and Trauma

“…This activation is usually of short duration (hours). Similar changes are found during and after surgery [3,8,9,22,43,50]. This early activation of the fibrinolytic system is not secondary to the changes in the coagulation system that also occur early after trauma.…”

Cardiac events in patients with negative maximal versus negative submaximal dobutamine echocardiograms undergoing noncardiac surgery

“…The detection of ischemia on preoperative stress testing identifies patients who are at an increased risk for cardiac events arising from prolonged supply-demand imbalance related to factors such as postoperative fever, anemia, tachycardia, or hypotension. Many perioperative infarctions, however, occur when no such imbalance is apparent, and are mediated by plaque rupture and thrombosis, in the context of intensified postoperative inflammatory or hypercoagulable state (18,19). Such a mechanism may elude preoperative detection if the culprit plaque is nonobstructive.…”

Plasminogen Activators and Plasminogen Activator Inhibitor before and after Surgery in Patients with and without Gastric Malignancy

“…Surgery has been reported to induce rather stereotyped changes in the fibrinolytic sys tem, detectable as an intraoperative shorten ing and as a postoperative prolongation of the euglobulin lysis time [2,4,5,[7][8][9][10][11] and a post operative increase in PAI:Act with concomi tant decrease in tPA:Act in spite of unchanged or increased levels of tPA:Ag [7,9,[11][12][13][14][15]. 254 Rahr/Sarensen/I-arsen/Jensen/Bredahl Plasminogen Activators and Inhibitor in Surgery Similar changes were found in the present study.…”