Relationship of erythrocyte sedimentation rate with the activity of prolidase and liver enzyme in serum of patients with rheumatoid arthritis

Jassim, Hala Hameed Majeed; Alnassiri, Shurooq hameed majeed; Mawlood, Afaf Farooq; Shnak, Qadir Abdullah

doi:10.1016/j.matpr.2020.11.845

Cited by 2 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous research showed that serum aminotransferases (AST and ALT) and ALP markedly increased in RA patients compared to controls. 38 These results confirm the metabolic relationships of miR-4270, miR-4441, and miR-146 with RA (Figure 5). However, more research is needed to elucidate these connections fully.…”

Section: Discussionsupporting

confidence: 82%

The Association between the Expression of MicroRNA-4270 and MicroRNA-4441 with some Metabolic Factors in Iranian Rheumatoid Arthritis Patients

Ghodoosifar,

Dehghan,

Safaralizadeh

et al. 2024

IJAAI

View full text Add to dashboard Cite

MicroRNAs (miRs) play a role in several diseases, such as rheumatoid arthritis (RA). The purpose of this study was to discover new microRNAs and investigate their involvement in RA, examining their connections with inflammation and metabolic markers. New microRNAs related to RA were predicted using Mirbase and TargetScan databases based on RA target genes. The relationships between miRNAs and targets were visualized with Cytoscape software. Real-time polymerase chain reaction confirmed detectable miRNAs and metabolic factors were assessed using immunoassay and spectrometry methods in RA patients and healthy subjects. Four microRNAs (hsa-miR-153-5p, hsa-miR-4270, hsa-miR-4441, and hsa-miR-6754-5p) showed the highest correlation with RA target genes among millions of microRNAs. The expression of miR-146b (fold change=1.8) and miR-4441 (fold change=1.7) was notably reduced, while miR-4270 showed upregulation (fold change=1.8) in plasma from RA patients compared to healthy individuals. MiR-6754 exhibited a decrease (fold change=1.3) but was statistically insignificant. MiR-153-5p expression was undetectable in plasma. Receiver operating characteristic (ROC) curve analysis indicated that miR-4441, with an area under the ROC curve (AUC) of 0.7728, and miR-4270 (AUC=0.7353) were promising biomarkers for RA. The expression of these studied miRNAs significantly correlated with essential clinical characteristics, including liver enzymes, cholesterol, phosphorus, and vitamin D3. Our findings suggest that miR-4270 and miR-4441, present in the circulation, exhibit distinct expression patterns in RA. These microRNAs may serve as links between inflammation and metabolism and represent promising new biomarkers for this disease.

show abstract

Section: Discussionsupporting

confidence: 82%