Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin

Dickey, Richard P.; Olar, Terry T.; Taylor, Steven N.; Curole, David N.; Matulich, Ellen M.

doi:10.1016/s0015-0282(16)55855-5

Cited by 159 publications

(98 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are several mechanisms which may mediate increased fecundity or fertility. Oestrogen levels correlate with follicle size, oocyte quality, thickness of endometrium (Eissa et al 1986;Dickey et al 1993) and penetrability of cervical perfusion (Roumen et al 1982). Progesterone is also essential for endometrial maturation (Santoro et al 2000) and cell growth (Chaffkin et al 1993).…”

Section: Introductionmentioning

confidence: 99%

Facial appearance is a cue to oestrogen levels in women

et al. 2005

View full text Add to dashboard Cite

Although many accounts of facial attractiveness propose that femininity in women's faces indicates high levels of oestrogen, there is little empirical evidence in support of this assumption. Here, we used assays for urinary metabolites of oestrogen (oestrone-3-glucuronide, E1G) and progesterone (pregnanediol-3-glucuronide, P3G) to investigate the relationship between circulating gonadal hormones and ratings of the femininity, attractiveness and apparent health of women's faces. Positive correlations were observed between late follicular oestrogen and ratings of femininity, attractiveness and health. Positive correlations of luteal progesterone and health and attractiveness ratings were marginally significant. Ratings of facial attributions did not relate to hormone levels for women wearing make-up when photographed. There was no effect of sex of rater on the relationships between oestrogen and ratings of facial appearance. These findings demonstrate that female facial appearance holds detectable cues to reproductive health that are considered attractive by other people.

show abstract

Section: Introductionmentioning

confidence: 99%

Facial appearance is a cue to oestrogen levels in women

et al. 2005

View full text Add to dashboard Cite

show abstract

“…20 Dickey, et al studied on relationship of endometrial thickness to fecundity in ovulation induction cycles and concluded that no pregnancy occurred when thickness was less than 6mm, but the continuing pregnancy rate was 12.6% when thickness was more than or equal to 9mm. 21 Weissman, et al study observed a detrimental effect of increased endometrial thickness >14mm on pregnancy rates.…”

Section: Endometrial Thicknessmentioning

confidence: 96%

Factors affecting success of intrauterine insemination: a 3 year prospective study

Jayakrishnan¹,

Abraham²,

Nambiar³

2016

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

INTRODUCTIONIntrauterine insemination (IUI) is the therapeutic process of placing washed spermatozoa transcervically into the uterine cavity for the treatment of infertility. IUI theoretically allows a relatively higher number of motile spermatozoa to reach the oocyte and it has been used for a variety of indications such as non-severe male factor infertility, unexplained infertility, cervical mucus hostility, ovulatory disturbances, mild endometriosis, antisperm antibodies and male sexual dysfunctions like impotency, hypospadias, and retrograde ejaculation. [1][2][3][4] The rationale behind IUI is increasing the gamete density at the time and site of potential fertilization i.e., increasing the chances of spermatozoa meeting the oocyte in the fallopian tube after ovulation has occurred. IUI is generally considered as an intermediate step of low to moderate complexity before the application of more sophisticated assisted reproductive technologies (ART) such as IVF with or without ICSI.The overall success rates of IUI remains controversial and depends on several factors, with published pregnancy rates varying from as low as 5% to as high as 70% per patient, however a 10%-20% clinical pregnancies per cycle is an acceptable range for all aetiologies.2 The pregnancy rates per IUI cycle are quite variable in the literature due to differences in cause and duration of infertility, type of ovarian stimulation, sperm preparation techniques, treatment cycles and number of times IUI is performed during a cycle (single or double). Results:The overall pregnancy rate was 15.2%. Among the predictive factors evaluated, the infertility diagnosis (PCO and male factor, p value <0.001), the post wash semen count (5-10 million, p value <0.001), type of IUI (double IUI over single IUI, p value <0.001) and the endometrial thickness on the day of trigger (9-10mm, χ2 =551.59 df =5 p<0.001) significantly influenced the pregnancy rate. Conclusions: IUI is a successful contemporary treatment for appropriately selected cases of PCO and male factor infertility, especially when female age is <35 years.

show abstract

“…38 Thus, endometrial thickness may be a factor contributing to the discrepancy between ovulation (60-85%) and pregnancy rates (around 36%) with the use of CC. 39,40 Since a thin endometrium is a critical factor for implantation failure, preventing CC induced thinning of the endometrium by adding exogenous estrogens during CC stimulation is important. 8 A relationship between CC treatment and endometrial cancer investigated by many retrospective studies.…”

Section: Groupsmentioning

confidence: 99%

The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment

Özdemır¹,

Erol²,

Cevrioğlu³

et al. 2015

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

lomiphene citrate (CC) a nonsteroidal tissue selective estrogen receptor modulator was approved for clinical use in 1967. [1][2][3] CC is the first line treatment for women with ovulatory disorders who are Turkiye Klinikleri J Med Sci 2015;35(4) 209 The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Clomiphene citrate (CC) a nonsteroidal tissue selective estrogen receptor modulator is used for inducing ovulation. In this study, we aimed to investigate the histopathological changes and dose related effects of long term CC treatment on rat ovary and endometrium. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Four groups of female rats were included in the study. In group 1 (control) only saline was administered whereas in groups 2, 3 and 4 CC was (once a week) administered for 18 weeks at the doses of 1 mg/kg, 4 mg/kg and 8 mg/kg, respectively. Uterus and both ovaries were excised for histopathological evaluation. R Re es su ul lt ts s: : Histopathological examination showed that papillary hyperplasia of the surface epithelium of the ovary was present in all CC treated groups, with the highest percentage and severity in group 4. The mean values of endometrial thickness and endometrial gland diameters in this group were lower than those in groups 1 and 2 (p<0.05). Diameters of ovaries and ovarian surface epithelium in group 4 were decreased with respect to control group (p<0.05). C Co on nc cl lu us si io on n: : High doses and repetitive treatment with CC may have detrimental effects in terms of endometrial thinning and developing precancerous lesions in the ovaries.K Ke ey y W Wo or rd ds s: : Clomiphene; pathology; endometrium; ovary; rats; time Ö ÖZ ZE ET T A Am ma aç ç: : Klomifen sitrat (CC) ovulasyon indüksiyonunda kullanılan, steroid yapıda olmayan, seçici özellikte östrojen reseptör modülatörüdür. Bu çalışmada, uzun süreli CC tedavisinin rat ovaryumu ve endometriyumundaki histopatolojik değişikliklerin uygulanan dozla ilişkisi araştırıldı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışma her grupta yedi dişi rat bulunan dört grupta yapıldı. Grup 1'e (kontrol) fizyolojik tuzlu su verilirken grup 2, 3 ve 4'e klomifen sitrat sırasıyla 1 mg/kg, 4 mg/kg ve 8 mg/kg dozlarda 18 hafta boyunca haftada bir kez oral yolla uygulandı. Çalışmanın sonunda uterus ve her iki ovaryum histopatolojik değerlendirmeler için eksize edildi. B Bu ul lg gu ul la ar r: : Histopatolojik çal-ışmalar, klomifen sitrat uygulanan bütün grupların ovaryum yüzey epitellerinde papiller hiperplazi meydana geldiğini gösterdi; grup 4'te papiller hiperplazinin şiddeti ve yüzdesi daha yüksek belirlendi. Bu grupta endometrial bezlerin çapları ve endometrial kalınlıklarının ortalama değerlerinin grup 1 ve grup 2'den daha düşük olduğu bulundu (p<0,05). Grup 4'teki ovaryum yüzey epiteli ve ovaryum çapları da kontrol grubu ile karşılaştırıldığında azaldığı saptandı (p<0,05). S So on nu uç ç: : Yüksek dozda ve uzun süreli...

show abstract

Relationship of endometrial thickness and pattern to fecundity in ovulation induction cycles: effect of clomiphene citrate alone and with human menopausal gonadotropin

Cited by 159 publications

References 23 publications

Facial appearance is a cue to oestrogen levels in women

Facial appearance is a cue to oestrogen levels in women

Factors affecting success of intrauterine insemination: a 3 year prospective study

The Histopathological Changes in Rat Ovary and Endometrium Following Long Term Clomiphene Treatment

Contact Info

Product

Resources

About