Relationship of cytokines, oxidative stress and GI motility with bacterial overgrowth in ulcerative colitis patients

Abstract

This study indicates that increase in cytokines and decrease in anti-oxidants in UC patients would have resulted in oxidative stress causing delayed GI motility leading to SIBO.

Systematic review with meta‐analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease

“…In total, the eleven studies reported the prevalence of SIBO in 1175 IBD patients. Nine studies utilised GBT and only one study each utilised LBT and 14 C‐glycocholate breath test for diagnosing SIBO in IBD patients (Table ), hence we did not do a subgroup analysis according to the type of breath test utilised to diagnose SIBO in patients with IBD. Overall, 262/1175 (22.3%, 95% CI 19.92‐24.68) IBD patients (Figure ), 215/846 (25.4%, 95% CI 22.48‐28.…”

“…Fifteen articles were excluded as ineligible leaving eleven appropriate studies (Figure ). Ten of these studies included patients with CD, four included patients with UC, while three included both UC and CD patients (two case‐control studies and one cohort study). None of the studies included patients with unclassified IBD.…”

“…None of the studies included patients with unclassified IBD. Five of the eleven studies were case control studies and the remaining six were cohort studies . All case‐control studies included healthy volunteers in the non‐IBD control group; however, one study included patients undergoing evaluation of unexplained GI symptoms as a control group.…”

“…The characteristics of all the studies in the current meta‐analysis including the methodology pertaining to diagnosis of SIBO and patient characteristics are outlined in Tables and S1. Three of the eleven studies were conducted in Italy, two in India and one each in Canada, Belgium, Korea, Brazil, Spain and Germany …”

Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function

“…Inflammatory bowel disease (IBD) is characterized by severe inflammation of the small bowel and/or colon, resulting in recurrent diarrhea and abdominal pain. Crohn's disease and ulcerative colitis are the two major forms of IBD . The pathogenesis of IBD is complex and multifactorial, as environmental, microbial, genetic, and immune influences lead to relapsing acute inflammation and intestinal tissue damage.…”