Relationship of Cystatin C, Hs-CRP, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio with isolated oligohydramnios

Abstract

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Can systemic immune inflammation index measured in the first trimester predict later occurring isolated oligohydramnios?

“…In agreement with our PLR findings, Erten O et al reported significantly higher cystatin C, hs-CRP, and PLR values in the third trimester in an oligohydramnios group compared to a control group. However, again similarly to the present research, that study found no significant difference in NLR values between the two groups [7]. Smiliary to present study, another study comparing high-risk pregnant women and the normal population in the third trimester also reported no association between NLR values and adverse obstetric outcomes [18].…”

“…[12]. All these inflammatory processes suggest that an inflammatory process plays a role in the pathogenesis of IO [7].…”

“…Studies showing that poor obstetric outcomes may be a result of inflammatory processes are available in the literature [2,5,7,8].…”

“…These poor obstetric outcomes associated with oligohydramnios are thought to be related to placental insufficiency [11]. Additionally, a progressive decrease in uteroplacental flow causes activation of neutrophils in the fetus in the subsequent stages of pregnancy and increased chemokine release by resulting in chronic hypoxia [7]. Similar to neutrophils, platelets contribute both to the initiation of inflammation by increasing the secretion of cytokines and to the continuation of inflammation by increasing the production of neutrophils and platelets.…”

“…Two such indices, the neutrophil-lymphocyte ratio (NLR) and the plateletlymphocyte ratio (PLR), are simple biomarkers widely employed for the detection of systemic inflammation [6]. Both NLR and PLR have been shown to be correlated with cancer and several inflammatory diseases, and have begun being regarded as likely inflammatory markers [6][7]. The system immune-inflammation index (SII), used as a novel inflammatory biomarker in recent years, has been shown to be associated with adverse obstetric outcomes such as placental pathologies [8][9].…”