Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in <scp>T</scp>urkish patients with ankylosing spondylitis

Okyaltirik, Fatmanur; Rezvanı, Aylin; Turan, Saime; Uysal, Ömer; Yakar, Fatih; Sozgen, Hatice; Ozkan, Nazli Ezgi; Akkoyunlu, Muhammet Emin; Bayram, Mehmet; Özçelik, Hatice Kutbay; Sezer, Murat; Güler, Mustafa; Yaylım, İlhan; Kart, Levent

doi:10.1111/crj.12388

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…The mice developed abnormal immune activation, multiorgan lymphocyte infiltration, and autoantibodies in a short period of time [42]. CTLA-4 polymorphisms have been significantly associated with autoimmune disorders, namely AS, Graves' disease, and rheumatoid arthritis, in British Caucasian, Irish Caucasian, Iranian, West Algerian, and West Mexican populations but not in a Turkish population [43][44][45][46][47]. It is interesting that the HLA genes and the CTLA-4 proteins were connected through the CD3E protein (Fig.…”

Section: Discussionmentioning

confidence: 98%

Differential gene expression analysis of ankylosing spondylitis shows deregulation of the HLA-DRB, HLA-DQB, ITM2A, and CTLA4 genes

AlEjielat

Khaleel

Tarkhan³

2021

Egypt J Med Hum Genet

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Background Ankylosing spondylitis (AS) is a rare inflammatory disorder affecting the spinal joints. Although we know some of the genetic factors that are associated with the disease, the molecular basis of this illness has not yet been fully elucidated, and the genes involved in AS pathogenesis have not been entirely identified. The current study aimed at constructing a gene network that may serve as an AS gene signature and biomarker, both of which will help in disease diagnosis and the identification of therapeutic targets. Previously published gene expression profiles of 16 AS patients and 16 gender- and age-matched controls that were profiled on the Illumina HumanHT-12 V3.0 Expression BeadChip platform were mined. Patients were Portuguese, 21 to 64 years old, were diagnosed based on the modified New York criteria, and had Bath Ankylosing Spondylitis Disease Activity Index scores > 4 and Bath Ankylosing Spondylitis Functional Index scores > 4. All patients were receiving only NSAIDs and/or sulphasalazine. Functional enrichment and pathway analysis were performed to create an interaction network of differentially expressed genes. Results ITM2A, ICOS, VSIG10L, CD59, TRAC, and CTLA-4 were among the significantly differentially expressed genes in AS, but the most significantly downregulated genes were the HLA-DRB6, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRB1, HLA-DQB1, ITM2A, and CTLA-4 genes. The genes in this study were mostly associated with the regulation of the immune system processes, parts of cell membrane, and signaling related to T cell receptor and antigen receptor, in addition to some overlaps related to the IL2 STAT signaling, as well as the androgen response. The most significantly over-represented pathways in the data set were associated with the “RUNX1 and FOXP3 which control the development of regulatory T lymphocytes (Tregs)” and the “GABA receptor activation” pathways. Conclusions Comprehensive gene analysis of differentially expressed genes in AS reveals a significant gene network that is involved in a multitude of important immune and inflammatory pathways. These pathways and networks might serve as biomarkers for AS and can potentially help in diagnosing the disease and identifying future targets for treatment.

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Section: Discussionmentioning

confidence: 98%

Differential gene expression analysis of ankylosing spondylitis shows deregulation of the HLA-DRB, HLA-DQB, ITM2A, and CTLA4 genes

AlEjielat

Khaleel

Tarkhan³

2021

Egypt J Med Hum Genet

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“…Restrictive lung disease observed in patients with AS is associated with chest cage rigidity and reduced spinal mobility rather than pulmonary parenchymal disease [ 17 ]. Although the consideration that smoking causes interstitial inflammation and pulmonary parenchymal destruction is widely accepted, smoker and nonsmoker AS patients presented similar rates of abnormal HRCT findings [ 9 , 12 , 18 , 19 ]. Turetschek et al have reported the incidence of abnormal HRCT finding as 71% in the nonsmoker AS patients [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of anti-TNF agents with proven efficacy in the AS patients with resistant axial and peripheral arthritis on the pulmonary involvements has not been widely investigated [ 22 ]. In a recent study, 27 of 89 AS patients (30.3%) received anti-TNF treatment; however, no association was detected between anti-TNF treatment and HRCT findings or PFT results [ 19 ]. Bargagli et al have reported a beneficial effect of infliximab in the treatment of interstitial lung disease associated with rheumatoid arthritis [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Rapidly Progressive Pulmonary Apical Fibrosis and Parenchymal Destruction in a Patient with Ankylosing Spondylitis

Ulusoy

Tuna

Sayit

2020

Case Reports in Rheumatology

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Pulmonary apical fibrosis is a rare complication of ankylosing spondylitis (AS). The essential characteristics of this lesion are its very slow progression and frequently asymptomatic nature. Herein, we are presenting a patient with AS who rapidly developed pulmonary apical fibrosis in a 3-year period despite decreased musculoskeletal pains. The 60-year-old male applied with complaints of progressively increasing cough in the recent two years, dyspnea, and fatigue. He had no chronic disease except AS. He had no continuous medication except nonsteroid anti-inflammatory drugs for 2-3 days monthly since his musculoskeletal pains decreased in the recent years. His physical examination revealed reduced breath sounds in the upper zones of the right lung. Chest X-ray revealed increased diffuse opacity in the upper zones of the right lung. Thoracic high-resolution computed tomography showed a consolidation accompanied with traction bronchiectases compatible with chronic fibrosis in the upper lobe of the right lung. However, thoracic computed tomography of the patient performed 3 years ago did not reveal pulmonary apical fibrosis and parenchymal destruction. Biopsy revealed no finding of malignancy, granulomatous inflammation, or vasculitis. The results of cultures were negative. So, the patient was diagnosed as pulmonary involvement of AS, which developed in a 3-year period. This case has shown that extra-articular complications may continue to develop in patients with AS even if their musculoskeletal complaints have subsided. So, patients with AS should be followed up regularly with systemic examinations.

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Association of CTLA-4 (+49 A/G) polymorphism with susceptibility to autoimmune diseases: A meta-analysis with trial sequential analysis

Shao

Zhou

et al. 2021

International Immunopharmacology

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Relationship of CTLA4 and CD28 polymorphisms with lung involvement, HRCT findings and pulmonary function tests in Turkish patients with ankylosing spondylitis

Abstract: Our results suggest a possible association of CTLA4 and CD28 variants with AS pulmonary involvement. Furthermore, these results may lead to the development of new therapeutic agents to control more aggressive forms of the disease. However, further studies are needed in larger populations.

Cited by 5 publications

References 34 publications

Differential gene expression analysis of ankylosing spondylitis shows deregulation of the HLA-DRB, HLA-DQB, ITM2A, and CTLA4 genes

Differential gene expression analysis of ankylosing spondylitis shows deregulation of the HLA-DRB, HLA-DQB, ITM2A, and CTLA4 genes

Rapidly Progressive Pulmonary Apical Fibrosis and Parenchymal Destruction in a Patient with Ankylosing Spondylitis

Association of CTLA-4 (+49 A/G) polymorphism with susceptibility to autoimmune diseases: A meta-analysis with trial sequential analysis

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