Relationship of Cord Blood Immunoglobulin E and Maternal Immunoglobulin E with Birth Order and Maternal History of Allergy in Albanian Mother/Neonate Pairs

Abstract

BACKGROUND:Previous studies reported that familial factors such as birth order and mothers atopy might influence cord blood levels and development of allergies.AIM:The aim of the study was to evaluate the relationship of cord blood IgE and maternal IgE with birth order and mothers history of allergy in Albanian mother/neonate pairs.MATERIAL AND METHODS:Study population represented 291 mother-infant pairs. Mothers were interviewed with a questionnaire for personal history of allergy and pregnancy history whereas serum IgE levels were determined using sandwich IRMA assay.RESULTS:The mean level of cIgE in neonates with detectable levels was 1.59 (n = 78). No significant difference in means of cIgE was found between first born and later born neonates (p = 0.232) and between neonates of mothers with a negative and positive history of allergy (p = 0.125). Also, no significant difference was found between means of mIgE by birth order, whereas there was a significant difference of mIgE between mothers with and without a history of allergy (p = 0.01). In a group of neonates with detectable cIgE levels, maternal IgE levels were moderately correlated with cIgE levels.CONCLUSION:Cord blood IgE is not affected by birth order and mothers history of allergy, whereas mothers IgE are affected by the history of allergy but not by birth order.

Relationship of cord blood IgE with maternal, fetal, and environmental factors in the Chinese population

“…In this study, we found that CB-IgE levels were not normally distributed and that most CB-IgE levels were below 0.5 kU/L, as stated in previous reports. 9 A total of 268 (27.10%) infants had elevated CB-IgE (≥0.5 kU/L), which was similar to Ferguson et al 13 (19.30%) and Chieh-An Liu et al's (23.70%) reports. 14 Most studies have shown that elevated CB-IgE levels have a role in the future development of allergic diseases.…”

“…[4][5][6] Nowadays, although various studies demonstrated that elevated CB-IgE is affected by some different factors including maternal, paternal, placenta, and fetal characteristics, findings on each factor have been inconclusive and discordant. [7][8][9][10] And results remain difficult to compare because of the influence of genetics and different ethnic groups on the CB-IgE. 11,12 Regarding the scarcity of studies about CB-IgE in Chinese Han newborns, more studies are needed to be performed on different populations and situations.…”