Relationship of common vascular endothelial growth factor polymorphisms and haplotypes with the risk of cervical cancer in Tunisians

Analysis of VEGFA Variants and Changes in VEGF Levels Underscores the Contribution of VEGF to Polycystic Ovary Syndrome

“…While not tested for its possible association with PCOS, rs3025020 (-583T>C) was previously linked with increased risk of recurrent pregnancy loss in Bahraini [24] and Chinese [25] women. While some of the SNPs included here were previously investigated in relation to other adverse pregnancy complications, including ovarian hyper-stimulation syndrome [35], recurrent miscarriage [24, 25], preeclampsia [22, 23], ovarian cancer [21], and cervical cancer [26] with variable results. As such, our finding on its association with PCOS expands the contribution of rs3025020 to adverse pregnancy complications.…”

“…Two studies conducted on Turkish [19] and South Indian [20] cohort revealed no association between -2578C/A and -460T/C VEGFA SNPs and PCOS. Other studies that investigated the association between VEGFA SNPs and adverse pregnancy outcomes, such as ovarian hyperstimulation syndrome, ovarian cancer [21], pre-eclampsia [22, 23], spontaneous miscarriage [24, 25], and cervical cancer [26] yielded mixed results. This study evaluated the association of VEGFA variants with altered VEGF level and PCOS in 382 Bahraini Arab women with PCOS, and 393 age- and ethnically-matched control women.…”

Association between SNPs in vascular endothelial growth factor polymorphisms and risk of renal cell carcinoma: a case-control study

“…A case-control study in a Chinese population suggested that VEGF -2578C/A polymorphism plays an important role in the pathogenesis of osteosarcoma (Tie et al, 2014). Another case-control study investigated the association between common SNPs in VEGF and risk of cervical cancer in a Tunisian population, and it suggested that VEGF -2578C/A polymorphism may contribute to the development of cervical cancer (Zidi et al, 2014). In a case-control study in a Portuguese population, findings suggested that VEGF -2578C/A polymorphism was associated with an increased risk of hepatocellular carcinoma (Machado et al, 2014).…”

“…Previous studies reported the association between polymorphisms in VEGF -2578C/A and risk of cancer (Tie et al, 2014;Zidi et al, 2014;Machado et al, 2014;Deng et al, 2014;Chen et al, 2014). A case-control study in a Chinese population suggested that VEGF -2578C/A polymorphism plays an important role in the pathogenesis of osteosarcoma (Tie et al, 2014).…”

Interplay among cytokines and T cell subsets in the progression and control of immune-mediated diseases

“…Almawi and colleagues [61] tested the association between VEGF polymorphisms and cervical cancer, and reported that specific VEGF variants and a defined haplotype (CTGCCAG) contributed to the risk of cervical cancer. Kahyaoglu and colleagues [62] described the role of cytokines in modulating hormones in ovarian function, and demonstrated that granulocyte-colony stimulating factor (G-CSF) was increased in serum as well as follicular fluid from patients with polycystic ovary syndrome.…”