Relationship of Common Laboratory Parameters to the Activity of Crohnʼs Disease in Children

Peripheral Blood Intracellular Cytokine Analysis in Children Newly Diagnosed with Inflammatory Bowel Disease

“…The mean time of onset of symptoms to time of diagnosis was approximately 14 mo for subjects with CD and 5 mo for subjects with UC (p ϭ 0.18). The mean (ϮSD) PCDAI score at the time of diagnosis was 38.4 Ϯ 14.2 points, and a subject with a PCDAI score Յ10 was considered to have inactive disease in this study (12,13).…”

In vitro release of eosinophil cationic protein from peripheral eosinophils reflects disease activity in childhood Crohn disease and ulcerative colitis

“…Severity of CD was rated from 0 to 100 using the Paediatric CD Activity Index (PCDAI) [11]. A score of 0±10 denotes inactive disease, 11±30 mild disease, and a score above 30 signi®es moderate to severe disease.…”

“…Since three routine laboratory parameters (ESR, albumin and haematocrit) are part of the PCDAI [11], the PCDAI was recalculated without the laboratory values so as not to aect the correlations between the laboratory parameters and the PCDAI. According to Hyams et al [11], the PCDAI scores without ESR, albumin and haematocrit are denoted as PCDAI-1, PCDAI-2 and PCDAI-3, respectively. Since ESR and haemoglobin are part of the UC disease activity index [18], it was recalculated without these laboratory values (denoted as Index-1 and Index-2, respectively).…”

Campylobacter concisus utilizes blood but not short chain fatty acids despite showing associations with Firmicutes taxa

“…S1, available in the online Supplementary Material. The Pediatric Crohn's Disease Activity Index (PCDAI) for each patient was calculated at diagnosis (baseline, week 0) and at 2, 4, 6, 8, 16 and 26 weeks post commencement of EEN (Hyams et al, 1992). Disease remission was defined as PCDAI <10.…”