Relationship of cognitive impairment with depressive symptoms and psychosocial function in patients with major depressive disorder: Cross–sectional analysis of baseline data from PERFORM-J

Sumiyoshi, Tomiki; Watanabe, Koichiro; Noto, Shinichi; Sakamoto, Shigeru; Moriguchi, Yoshiya; Tan, Khee Giap; Hammer-Helmich, Lene; Fernandez, Jovelle

doi:10.1016/j.jad.2019.07.064

Cited by 47 publications

(54 citation statements)

References 25 publications

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“…Most patients reported cognitive symptoms and over half were shown to have impaired cognitive performance by DSST. Mean DSST score at the time of treatment of initiation in this study (50.7) was similar to that reported in Japanese patients initiating new antidepressant therapy in another recent study (54.3), 44 but higher than those reported in comparable US and European populations (42.0 in FOCUS and 43.1 in CONNECT). 36,45 This may at least partly reflect cultural differences between the different geographic populations.…”

Section: Discussionsupporting

confidence: 88%

Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study

Wang¹,

Tan²,

Ren³

et al. 2020

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Purpose: This post hoc analysis was undertaken to further explore the association of cognitive symptoms with health-related quality of life (HRQoL) and work productivity at the time of treatment initiation in Chinese patients with major depressive disorder (MDD) in the Prospective Research Observation to Assess Cognition in Treated patients with MDD (PROACT) study. Patients and Methods: This was an epidemiological, non-interventional, prospective cohort study in adult outpatients with moderate-to-severe MDD initiating antidepressant monotherapy (first or second line). Crude and adjusted analyses of covariance were performed to assess the association of perceived cognitive symptoms (20-item Perceived Deficits Questionnaire-Depression [PDQ-D] total score) or observed cognitive performance (Digit Symbol Substitution Test [DSST] score) with HRQoL (EuroQoL 5-Dimensions Questionnaire index) and work productivity (Work Productivity and Activity Impairment [WPAI] or Sheehan Disability Scale [SDS] absenteeism and presenteeism scores). Adjusted analyses included depression severity, age, sex, residential area (urban/rural), and educational level. Results: Of 1008 patients enrolled in the PROACT study, 986 were included in this analysis. Severity of perceived cognitive symptoms (ie, higher PDQ-D total score) was significantly associated with worse HRQoL (P<0.001) and higher levels of absenteeism (P=0.020 for the WPAI and P=0.002 for the SDS) and presenteeism (P<0.001 for both scales). The association of perceived cognitive symptoms with HRQoL and presenteeism was independent of depression severity. The association between observed cognitive performance (DSST score) and HRQoL was less robust. No association was seen between observed cognitive performance and levels of absenteeism or presenteeism assessed by either scale. Conclusion: Results of this real-world study illustrate the impact of cognitive symptoms on HRQoL and work productivity in Chinese patients with MDD, and highlight the importance of assessing and targeting cognitive symptoms in order to improve functional outcomes when treating patients with MDD.

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Section: Discussionsupporting

confidence: 88%

Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study

Wang¹,

Tan²,

Ren³

et al. 2020

NDT

Self Cite

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“…[1][2][3] Subjective cognitive difficulties are not significantly correlated with objective clinician-administered tests of cognitive performance, [4][5][6][7][8][9] but are significantly associated with a range of individual factors, including levels of stress, chronotype, substance use, sleep quality and mental health symptoms to name a few. 2,5,6,[10][11][12][13] People with depression and anxiety disorders appear especially susceptible to subjective cognitive difficulties; 1-3,9,14,15 these difficulties are associated with severity of affective symptoms [16][17][18][19] and have a negative impact on role functioning and quality of life. 9,16,17,20,21 Younger age is associated with higher levels of subjective cognitive difficulties in people with depression.…”

Section: Introductionmentioning

confidence: 99%

Subjective cognitive functioning in relation to changes in levels of depression and anxiety in youth over 3 months of treatment

et al. 2020

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Background Subjective cognitive difficulties are common in mental illness and have a negative impact on role functioning. Little is understood about subjective cognition and the longitudinal relationship with depression and anxiety symptoms in young people. Aims To examine the relationship between changes in levels of depression and anxiety and changes in subjective cognitive functioning over 3 months in help-seeking youth. Method This was a cohort study of 656 youth aged 12–25 years attending Australian headspace primary mental health services. Subjective changes in cognitive functioning (rated as better, same, worse) reported after 3 months of treatment was assessed using the Neuropsychological Symptom Self-Report. Multivariate multinomial logistic regression analysis was conducted to evaluate the impact of baseline levels of and changes in depression (nine-item Patient Health Questionnaire; PHQ9) and anxiety symptoms (seven-item Generalised Anxiety Disorder scale; GAD7) on changes in subjective cognitive function at follow-up while controlling for covariates. Results With a one-point reduction in PHQ9 at follow-up, there was an estimated 11–18% increase in ratings of better subjective cognitive functioning at follow-up, relative to stable cognitive functioning. A one-point increase in PHQ9 from baseline to follow-up was associated with 7–14% increase in ratings of worse subjective cognitive functioning over 3 months, relative to stable cognitive functioning. A similar attenuated pattern of findings was observed for the GAD7. Conclusions A clear association exists between subjective cognitive functioning outcomes and changes in self-reported severity of affective symptoms in young people over the first 3 months of treatment. Understanding the timing and mechanisms of these associations is needed to tailor treatment.

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“…Both depression severity and cognitive symptoms correlate with poor health-related QoL in major depressive disorder 2. According to recent research on depression, subjective cognitive function and depression severity correlate with psychosocial function; however, the objective cognitive function does not significantly correlate with psychosocial function 3. Lately, the association between subjective cognitive function, depressive symptoms, and QoL has been gaining attention not only in major depressive disorder but also in other mood disorders and with respect to adults in the general population.…”

Section: Introductionmentioning

confidence: 99%

Evaluation Of Subjective Cognitive Function Using The Cognitive Complaints In Bipolar Disorder Rating Assessment (COBRA) In Japanese Adults

Toyoshima¹,

Inoue²,

Masuya³

et al. 2019

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PurposeTo examine the relationship between depressive symptoms, subjective cognitive function, and quality of life in Japanese adults using the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA).Patients and methodsWe evaluated 585 adult community volunteers using the Patient Health Questionnaire-9 (PHQ-9) for evaluation of depressive symptoms and the COBRA for evaluation of subjective cognitive function. We additionally used the 8-item Short-Form Health Survey and the Sheehan Disability Scale to evaluate the quality of life (QoL).ResultsMeasures of subjective cognitive function were significantly correlated with depressive symptoms and QoL. Structural equation modeling demonstrated that depressive symptoms directly and indirectly decreased QoL via their effects on subjective cognitive dysfunction. Measures of depressive symptoms were more closely related to QoL than were measures of subjective cognitive function.LimitationsStudy participants were general adult population community volunteers and included healthy people; thus, these results may not be generalizable to patients with depression or bipolar disorder. In addition, the cross-sectional design of this study prevented the identification of causal relationships among the parameters.ConclusionChanges in subjective cognitive function may affect QoL via depressive symptoms. Evaluations of subjective cognitive function may help identify factors that reduce QoL.

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Relationship of cognitive impairment with depressive symptoms and psychosocial function in patients with major depressive disorder: Cross–sectional analysis of baseline data from PERFORM-J

Cited by 47 publications

References 25 publications

<p>Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study</p>

<p>Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study</p>

Subjective cognitive functioning in relation to changes in levels of depression and anxiety in youth over 3 months of treatment

<p>Evaluation Of Subjective Cognitive Function Using The Cognitive Complaints In Bipolar Disorder Rating Assessment (COBRA) In Japanese Adults</p>

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