Relationship of circulating MMP–2, MMP–1, and TIMP–1 levels with bone biochemical markers and bone mineral density in postmenopausal Chinese women

Luo, Xi; Guo, Lijuan; Shan, Peipei; Xie, Hui; Wu, Xianping; Zhang, H.; Cao, Xing-Zhi; Yuan, Ling‐Qing; Liao, Er-Yuan

doi:10.1007/s00198-005-0017-6

Cited by 27 publications

(19 citation statements)

References 28 publications

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“…Serum concentrations of MMP-2 have been related to markers of bone turnover including bone alkaline phosphatase, osteocalcin, and cross-linked N-telopeptides of type I collagen [47]. A previous study also found that serumMMP-2 levels may also increase with increasing bone turnover [48]. In the present study, women with one copy of the MMP2_C595T T allele (located in the 5′ promoter at position −1586) had a 21% lower adjusted rate of vertebral fracture, and women with two copies had a 56% lower adjusted rate.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variation in Candidate Osteoporosis Genes, Bone Mineral Density, and Fracture Risk: The Study of Osteoporotic Fractures

et al. 2008

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Candidate osteoporosis gene variants were examined for associations with fracture risk and bone mineral density (BMD). A total of 9704 white women were recruited at four U.S. clinical centers and enrolled into the Study of Osteoporotic Fractures, a longitudinal cohort study. Genotyping of 31 polymorphisms from 18 candidate osteoporosis genes was performed in 6752 women. Incident radiographic fractures were identified at the third and eighth examinations compared with the baseline examination. BMD was measured at the total hip by dual-energy X-ray absorptiometry. Analyses were adjusted for age, clinic site, and self-reported ethnicity. During a mean follow-up of 14.5 years, a total of 849 hip, 658 vertebral, and 2496 nonhip/nonvertebral fractures occurred in 6752 women. Women carrying the ALOX15_G48924T T/T genotype had a higher rate of hip fracture (hazard ratio [HR] = 1.33;95% confidence interval [95% CI] = 1.00-1.77) compared with the G/G genotype. Compared with those carrying the PRL_T228C T/T genotype, women with either the C/ C (HR = 0.80; 95% CI = 0.67-0.95) or C/T (HR = 0.81; 95% CI = 0.68-0.97) genotype had a lower rate of nonvertebral/nonhip fractures. Women carrying theBMP2_A125611G G/G genotype had a higher rate of vertebral fracture (odds ratio [OR] = 1.51; 95% CI = 1.03-2.23) compared with the A/ Correspondence to: Gregory J. Tranah. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptA genotype. Women with the ESR1_C1335G G/G genotype had a higher rate of vertebral fracture (OR = 1.64; 95% CI = 1.07-2.50) compared with the C/C genotype. Compared with those with the MMP2_C595T C/C genotype, women with the C/T (OR = 0.79; 95% CI = 0.65-0.96) or T/T (OR = 0.44; 95% CI = 0.27-0.72) genotype had a lower rate of vertebral fracture. In conclusion, polymorphisms in several candidate genes were associated with hip, vertebral, and nonhip/ nonvertebral fractures but not with total hip BMD in this large population based cohort study. KeywordsGenetics; Polymorphism; Osteoporosis; BMD; FractureOsteoporosis is a disorder characterized by low bone mass and increased risk of fracture. Many factors influence the risk of osteoporosis, including diet, physical activity, medication use, coexisting diseases, and a family history of the disorder. Research into the genetic basis of osteoporosis has been motivated by evidence that bone traits tend to be highly heritable. Whereas genetic factors explain 50% to 80% [1-4] of the biological variation in bone density and other bone phenotypes, these factors are not sufficient to explain fracture risk [5]. Deng et al. [5] report that the genetic correlation between bone density and fracture is not significant and that most genes found to be relevant to bone density may not be important for hip fracture.Osteoporosis, like other genetically complex diseases, is the product of multiple genetic and environmental factors, and their interactions [6,7]. To date, several approaches have been attempted to identify osteoporosis-related genes...

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Section: Discussionmentioning

confidence: 99%

Genetic Variation in Candidate Osteoporosis Genes, Bone Mineral Density, and Fracture Risk: The Study of Osteoporotic Fractures

et al. 2008

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“…We were not able to clearly distinguish from this design what type of vascular effect was due to isoflavones or to berberine, though we supposed it could be additive. Furthermore, MMP and TIMP levels could also have been related to changes in bone turn-over, 31 which was not evaluated in our study. Finally, TIMP dosage had large CVs, which reduced the reliability of the dosage itself.…”

Section: Discussionmentioning

confidence: 89%

Combined Nutraceutical Approach to Postmenopausal Syndrome and Vascular Remodeling Biomarkers

Cicero

Tartagni²,

Ferroni³

et al. 2013

The Journal of Alternative and Complementary Medicine

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“…Moreover, recent findings demonstrate how matrix metalloproteinases (MMPs), a family of enzymes that degrade extracellular matrix, can both stimulate smooth muscle cell migration through the internal elastic lamina into the intima, and generate monomeric collagen, therefore contributing to the development of atherosclerotic plaque [32]. MMPs are correlated positively with bone markers such as BAP and NTX [33]. All this evidence shows how bone turnover and carotid intima-media thickness seem to related.…”

Section: Discussionmentioning

confidence: 90%

Carotid intima-media thickness and bone turnover: the role of C-terminal telopeptide of type I collagen

et al. 2010

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Osteoporosis and vascular disease are commonly found together in elderly people. Several common mechanisms and risk factors have been suggested to contribute to the development of osteoporosis and atherosclerosis. The present cross-sectional study was performed to determine whether the degree of bone turnover is correlated to carotid intima-media thickness (CCA-IMT), as a marker of subclinical atherosclerosis. We selected 50 outpatients (mean age 71.7 +/- 12.3), underwent to eco-Doppler evaluation of extracranial carotid tract, without history of calcium and/or vitamin D supplementation, or antireabsorptive therapy. CCA-IMT was measured by high-resolution B-mode ultrasonography. Bone turnover was evaluated by analysing serum levels of C-terminal telopeptide of type I collagen (sCTX), and bone-specific alkaline phosphatase. We also evaluated the vitamin D status by determination of the serum concentration of 25-hydroxyvitamin D [25(OH)D]. We found a prevalence of hypovitaminosis D [serum 25(OH)D levels <30 ng/mL, mean value 10.7 +/- 5.8] of 91.8%, and an increased bone resorption, with mean sCTX levels higher than reference values (mean 1.18 +/- 0.57 ng/mL). A significant positive correlation was found between CCA-IMT and age (r = 0.480, P = 0.001), erythrocyte sedimentation rate (ESR: r = 0.438, P = 0.001), high-sensitivity C-Reactive Protein (HsCRP: r = 0.482, P = 0.011), serum creatinine (r = 0.305, P = 0.031), and sCTX (r = 0.389, P = 0.006). In a multivariate linear regression, CCA-IMT was independently predicted by age (beta = 0.34, P = 0.001), ESR (beta = 0.37, P = 0.005), and sCTX (beta = 0.32, P = 0.006). The preliminary results of our study seem to indicate that after adjustment for established cardiovascular risk factors, sCTX independently predict an increased CCA-IMT in the elderly population.

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Relationship of circulating MMP–2, MMP–1, and TIMP–1 levels with bone biochemical markers and bone mineral density in postmenopausal Chinese women

Abstract: In conclusion, our results suggest that circulating MMP-2 and markers of bone turnover are correlated, and serum MMP-2 levels may rise with increase in bone turnover.

Cited by 27 publications

References 28 publications

Genetic Variation in Candidate Osteoporosis Genes, Bone Mineral Density, and Fracture Risk: The Study of Osteoporotic Fractures

Genetic Variation in Candidate Osteoporosis Genes, Bone Mineral Density, and Fracture Risk: The Study of Osteoporotic Fractures

Combined Nutraceutical Approach to Postmenopausal Syndrome and Vascular Remodeling Biomarkers

Carotid intima-media thickness and bone turnover: the role of C-terminal telopeptide of type I collagen

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