Relationship of circulating immune cells with lifestyle factors and cancer recurrence in early-stage breast cancer

Xie, Eric; Lapinski, Maya M; Talamantes, Sarah M.; Nonyane, Bareng Aletta Sanny; Magalhães, Maria Cristina Figueroa; Visvanathan, Kala; Wolff, Antonio C.; Santa-Maria, Cesar A.

doi:10.1007/s10549-020-06016-3

Cited by 3 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The population dynamics were found to be sensitive to small changes in population levels for a range of (Figure 6B), suggesting an important role of the immune system in the effectiveness of OVT and cancer recurrences. This subject has also been investigated in several clinical and experimental studies [3,37,57,[60][61][62][68][69][70][71].…”

Section: Discussionmentioning

confidence: 99%

“…An immunosuppressive environment may promote virus replication and infection and enhance efficacy of OVT [37,62,72]. Cancer recurrence is associated with the host's immune system, and the tumor may remain in long-term dormancy after treatment in an active immune system [68][69][70][71]. Combination therapy that boosts the immune system after OVT is an appealing strategy to improve the efficacy of OVT and prevent tumor relapses [62,66].…”

Section: Discussionmentioning

confidence: 99%

“…P

\overset{\acute }{\mathrm{a}}

ez et al [70] pointed out that cancer cells may remain occult after treatment, leading to long‐term tumor dormancy in an equilibrium with an active immune system. Xie et al [71] conducted experiments and found that the immune cells may play an important role in breast cancer recurrence.…”

Section: Bifurcation Analysismentioning

confidence: 99%

See 2 more Smart Citations

The role of tumor activation and inhibition with saturation effects in a mathematical model of tumor and immune system interactions undergoing oncolytic viral therapy

Vithanage

Wei

Jang

2023

Math Methods in App Sciences

View full text Add to dashboard Cite

We propose and study a mathematical model governing interactions between cancer and immune system with an oncolytic viral therapy (OVT), wherein cancer cells can activate and inhibit immune cells simultaneously with saturations.When the therapy is not applied, it is shown that the interaction can support at most three hyperbolic positive equilibria where two of them are always asymptotically stable and the other is a saddle point. The reachable stable tumor burden can be either small or large depending on initial tumor size. We analyze the full model by proving global asymptotic stability of the virus-free equilibrium that corresponds to OVT failure. Sufficient conditions based on model parameters are derived under which the model is uniformly persistent. The proposed system is validated using a mouse model of human pancreatic cancer carried out by Koujima et al. Global sensitivity analysis indicates that the rates of tumor-mediated killing and immune cell exhaustion are critical for tumor progression and therapy success. Numerical bifurcation analysis reveals that the saddle point can be utilized to estimate the maximum tumor load for eradication by OVT. Moreover, an immunosuppressive microenvironment may enhance viral therapy efficacy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…P

\overset{\acute }{\mathrm{a}}

Section: Bifurcation Analysismentioning

confidence: 99%

See 1 more Smart Citation

The role of tumor activation and inhibition with saturation effects in a mathematical model of tumor and immune system interactions undergoing oncolytic viral therapy

Vithanage

Wei

Jang

2023

Math Methods in App Sciences

View full text Add to dashboard Cite

show abstract

“…The numbers and characteristics of leukocyte subtypes assessed in blood prior to cancer therapy have been linked to treatment responses, disease progression, mortality and recurrence ( Bassani et al, 2019 ; Palazón-Carrión et al, 2021 ; Tay et al, 2021 ; Xie et al, 2021 ). For example, it has been shown among gastric cancer patients prior to radical gastrectomy, that lower lymphocyte counts and higher monocyte counts were associated with poor prognosis and lower cumulative survival ( Feng et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study

et al. 2023

View full text Add to dashboard Cite

Methods: We examined whether immune cell profiles differ between healthy women (n = 38) and breast cancer survivors (n = 27) within 2 years of treatment, and whether any group-differences were influenced by age, cytomegalovirus infection, cardiorespiratory fitness and body composition. Using flow cytometry, CD4+ and CD8+ T cell subsets, including naïve (NA), central memory (CM) and effector cells (EM and EMRA) were identified using CD27/CD45RA. Activation was measured by HLA-DR expression. Stem cell-like memory T cells (TSCMs) were identified using CD95/CD127. B cells, including plasmablasts, memory, immature and naïve cells were identified using CD19/CD27/CD38/CD10. Effector and regulatory Natural Killer cells were identified using CD56/CD16.Results: Compared to healthy women, CD4+ CM were +Δ21% higher among survivors (p = 0.028) and CD8+ NA were −Δ25% lower (p = 0.034). Across CD4+ and CD8+ subsets, the proportion of activated (HLA-DR+) cells was +Δ31% higher among survivors: CD4+ CM (+Δ25%), CD4+ EM (+Δ32%) and CD4+ EMRA (+Δ43%), total CD8+ (+Δ30%), CD8+ EM (+Δ30%) and CD8+ EMRA (+Δ25%) (p < 0.046). The counts of immature B cells, NK cells and CD16+ NK effector cells were higher among survivors (+Δ100%, +Δ108% and +Δ143% respectively, p < 0.04). Subsequent analyses examined whether statistically significant differences in participant characteristics, influenced immunological differences between groups. Compared to healthy women, survivors were older (56 ± 6 y vs. 45 ± 11 y), had lower cardiorespiratory fitness (V̇O2max mL kg−1 min−1: 28.8 ± 5.0 vs. 36.2 ± 8.5), lower lean mass (42.3 ± 5.0 kg vs. 48.4 ± 15.8 kg), higher body fat (36.3% ± 5.3% vs. 32.7% ± 6.4%) and higher fat mass index (FMI kg/m2: 9.5 ± 2.2 vs. 8.1 ± 2.7) (all p < 0.033). Analysis of covariance revealed divergent moderating effects of age, CMV serostatus, cardiorespiratory fitness and body composition on the differences in immune cell profiles between groups, depending on the cell type examined. Moreover, across all participants, fat mass index was positively associated with the proportion of HLA-DR+ CD4+ EMRA and CD8+ EM/EMRA T cells (Pearson correlation: r > 0.305, p < 0.019). The association between fat mass index and HLA-DR+ CD8+ EMRA T cells withstood statistical adjustment for all variables, including age, CMV serostatus, lean mass and cardiorespiratory fitness, potentially implicating these cells as contributors to inflammatory/immune-dysfunction in overweight/obesity.

show abstract

“…Recently, various studies have shown a correlation between inflammatory and immune markers and the prognosis of solid malignancies. Among these markers, the absolute lymphocyte count (ALC) and neutrophil-to-lymphocyte ratio (NLR), which are easily obtainable and seem to reflect the immune and inflammatory status, have been widely evaluated due to their efficacy in predicting the prognosis of breast cancer (15)(16)(17)(18).…”

mentioning

confidence: 99%

Pretreatment Absolute Lymphocyte Count and Neutrophil-to-lymphocyte Ratio Are Prognostic Factors for Stage III Breast Cancer

et al. 2021

View full text Add to dashboard Cite

Background/Aim: Stage III breast cancer comprises a broad spectrum of disease, including the extent of supraclavicular/internal mammary lymph node metastasis. In this study, we evaluated the usefulness of the absolute lymphocyte count (ALC) and neutrophil-to-lymphocyte ratio (NLR) in predicting the prognosis of patients with stage III breast cancer. Patients and Methods: Seventy-five patients with stage III breast cancer who underwent surgery were included. We compared their clinicopathological factors according to the presence or not of supraclavicular/internal mammary lymph node metastasis, and pretreatment ALC or NLR. Results: Patients with metastasis of the studied lymph nodes had a poorer prognosis in comparison to those without metastasis. In patients without these types of lymph node metastasis, both the ALC and NLR were predictive factors for relapse-free and overall survival. Among these patients, those with a low ALC or high NLR had recurrence-free and overall survival comparable to those of patients with supraclavicular/internal mammary lymph node metastasis. Conclusion: Pretreatment ALC and NLR were prognostic factors for patients with stage III breast cancer.

show abstract

Relationship of circulating immune cells with lifestyle factors and cancer recurrence in early-stage breast cancer

Cited by 3 publications

References 22 publications

The role of tumor activation and inhibition with saturation effects in a mathematical model of tumor and immune system interactions undergoing oncolytic viral therapy

The role of tumor activation and inhibition with saturation effects in a mathematical model of tumor and immune system interactions undergoing oncolytic viral therapy

Immune cell status, cardiorespiratory fitness and body composition among breast cancer survivors and healthy women: a cross sectional study

Pretreatment Absolute Lymphocyte Count and Neutrophil-to-lymphocyte Ratio Are Prognostic Factors for Stage III Breast Cancer

Contact Info

Product

Resources

About