Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults

Felitti, Vincent J.; Anda, Robert F.; Nordenberg, Dale; Williamson, David F.; Spitz, Alison M.; Edwards, Valerie J.; Koss, Mary P.; Marks, James S.

doi:10.1016/s0749-3797(98)00017-8

Cited by 13,349 publications

(7,677 citation statements)

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“…For example, the ACE study, which included 9508 participants, found increased ORs in association with the number of maltreatment types experienced for the health conditions assessed in this study (Felitti et al, 1998). Similarly, another cross-sectional survey, which included data on 53,998 individuals from the USA, found increased ORs for diabetes, myocardial infarction and stroke depending on the number of adverse childhood events reported (Gilbert et al, 2015).…”

Section: Discussionmentioning

confidence: 68%

“…In the first large epidemiological study in the USA assessing the impact of maltreatment during childhood on physical health in adulthood, Felitti et al (1998) showed that subjects who had experienced child maltreatment had an increased risk for several diseases which are among the leading causes of death worldwide. Depending on the number of maltreatment experiences encountered, the odds ratio (OR) was reported to be increased by up to 1.6 for severe obesity, 2.2 for ischaemic heart disease, 1.9 for the occurrence of any kind of cancer, 2.4 for stroke, 3.9 for chronic bronchitis or emphysema and 1.6 for diabetes (Felitti et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…Depending on the number of maltreatment experiences encountered, the odds ratio (OR) was reported to be increased by up to 1.6 for severe obesity, 2.2 for ischaemic heart disease, 1.9 for the occurrence of any kind of cancer, 2.4 for stroke, 3.9 for chronic bronchitis or emphysema and 1.6 for diabetes (Felitti et al, 1998). Other extended cross-sectional studies followed, confirming associations of child maltreatment with an enhanced risk for obesity, hypertension, diabetes, emphysema and cardiovascular diseases, including stroke and myocardial infarction (Afifi, Mota, MacMillan, & Sareen, 2013; Draper et al, 2008; L. K. Gilbert et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, although a high intercorrelation between different subtypes of maltreatment, as well as a cumulative effect of different maltreatment subtypes on long-term physical health, is well known (Draper et al, 2008; Felitti et al, 1998; Shields, Hovdestad, Gilbert et al, 2016; Shields, Hovdestad, Pelletier et al, 2016), there is a lack of analyses focusing on cumulative effects of different types of maltreatment by involving the number of subtypes of maltreatment experienced. Moreover, there is a lack of studies analysing the association of single subtypes of maltreatment and physical health.…”

Section: Introductionmentioning

confidence: 99%

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Association of child maltreatment subtypes and long-term physical health in a German representative sample

Clemens

Huber‐Lang

Plener

et al. 2018

European Journal of Psychotraumatology

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Background: Child maltreatment is a major public problem, associated with enormous consequences on the individual and socioeconomic level. Studies show a clear impact of child maltreatment on long-term physical health. However, there is a lack of analyses comprising a wide variety of subtypes of maltreatment and addressing cumulative effects of different maltreatment subtypes experienced during childhood on physical health. Objective: The objective of this analysis was to assess the association of different subtypes and the intensity of child maltreatment with long-term physical health outcomes. Methods: In a cross-sectional observational approach, a representative sample of the German population (N=2510) was assessed regarding socioeconomic information, their current health status, and their experiences of child maltreatment using the Childhood Trauma Questionnaire (CTQ). Chi2-Tests were performed to compare differences of physical health conditions in adulthood in association with child maltreatment and binary regression analyses to assess the relationship of physical health and number of different subtypes of maltreatment experienced during childhood. Results: Odds increased significantly for obesity (1.8), diabetes (1.26), cancer (1.28), hypertension (1.16), chronic obstructive pulmonary disease (1.51), history of myocardial infarction (1.29) and stroke (1.31) with increasingenhancing number of experienced subtypes of child maltreatment. Growing intensity of each subtype of maltreatment was associated with higher rates of all assessed physical health conditions, which could point towards a dose-dependency of the relationship between maltreatment and long-term physical health. Conclusions: Child maltreatment is associated with increased odds for the leading morbidity and mortality causes in Germany. Interventions encompassing secondary and primary preventive strategies are critical to target this major public health problem and its devastating consequences.

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Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association of child maltreatment subtypes and long-term physical health in a German representative sample

Clemens

Huber‐Lang

Plener

et al. 2018

European Journal of Psychotraumatology

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“…It is well-established that the exposure to one or multiple forms of early-life stress (ELS), like childhood abuse and neglect, constitutes a major risk factor in the etiology of a wide range of somatic and/or psychiatric diseases (Anda et al, 2006; Felitti et al, 1998; Heim and Binder, 2012). However, it becomes increasingly apparent that these adverse long-term consequences are not restricted to the exposed individual alone but might be transmitted to the next generation (Collishaw et al, 2007), who also are at increased risk for psychiatric and somatic disorders (Roberts et al, 2014; Roberts et al, 2013) – a phenomenon referred to as intergenerational transmission (Bowers and Yehuda, 2016).…”

Section: Introductionmentioning

confidence: 99%

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Toepfer

Heim

Entringer

et al. 2017

Neuroscience & Biobehavioral Reviews

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Severe stress in early life, such as childhood abuse and neglect, constitutes a major risk factor in the etiology of psychiatric disorders and somatic diseases. Importantly, these long-term effects may impact the next generation. The intergenerational transmission of maternal early life stress (ELS) may occur via pre-and postnatal pathways, such as alterations in maternal-fetal-placental stress physiology, maternal depression during pregnancy and postpartum, as well as impaired mother-offspring interactions. The neuropeptide oxytocin (OT) has gained considerable attention for its role in modulating all of these assumed transmission pathways. Moreover, central and peripheral OT signaling pathways are highly sensitive to environmental exposures and may be compromised by ELS with implications for these putative transmission mechanisms. Together, these data suggest that OT pathways play an important role in the intergenerational transmission of maternal ELS in humans. By integrating recent studies on gene-environment interactions and epigenetic modifications in OT pathway genes, the present review aims to develop a conceptual framework of intergenerational transmission of maternal ELS that emphasizes the role of OT.

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Resolution of Intimate Partner Violence and Child Behavior Problems After Investigation for Suspected Child Maltreatment

Campbell¹,

Thomas²,

Cook³

et al. 2013

JAMA Pediatr

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Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults

Cited by 13,349 publications

References 53 publications

Association of child maltreatment subtypes and long-term physical health in a German representative sample

Association of child maltreatment subtypes and long-term physical health in a German representative sample

Oxytocin pathways in the intergenerational transmission of maternal early life stress

Resolution of Intimate Partner Violence and Child Behavior Problems After Investigation for Suspected Child Maltreatment

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