Relationship of Cardiovascular Risk Factors and Serum Ferritin with C-reactive Protein

Sung, Ki Chul; Kang, Jin Ho; Shin, Hun Sub

doi:10.1016/j.arcmed.2006.08.008

Cited by 19 publications

(19 citation statements)

References 20 publications

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“…In the context of cardiovascular disease, ferritin may exert a dual pro-inflammatory role. Its increased levels may represent an acute phase reactant equivalently to hsCRP [33], while the reduced concentration may also precipitate inflammation [34]. In summary, both high and low ferritin levels may relate to enhanced inflammation, inducing the progression of cardiovascular and other chronic diseases.…”

Section: Discussionmentioning

confidence: 99%

The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing

et al. 2017

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BackgroundFerritin constitutes a sensitive iron-storage index and multi-functional protein. Evidence on its association with mortality in general population is scarce and conflicting. We investigated the sex-specific associations of ferritin levels with all-cause and cardiovascular mortality in a population-based cohort.MethodsData came from the English Longitudinal Study of Ageing and the national mortality registry. The sample comprised 5,471 participants aged ≥52 years. Blood concentration of ferritin was measured at baseline in 2004–05. Sex-specific Cox proportional hazards models were estimated with adjustment for age, major chronic diseases, marital status, educational attainment, total net household wealth, anemia, inflammatory markers, body mass index, smoking, and physical activity. Stratified analyses by chronic disease status were also performed.ResultsWe categorized ferritin in sex-specific quartiles. In men, we used, the following categorization: lowest (2-69ng/ml), second lowest (70-118ng/ml), second highest (reference category) (119-193ng/ml) and highest (194-598ng/ml) ferritin quartiles. In women, ferritin was categorized as follows: lowest (2-44ng/ml), second lowest (45-73ng/ml), second highest (reference category) (74-115ng/ml) and highest (116-341ng/ml) ferritin quartiles. 841 deaths of which 262 cardiovascular disease-related were recorded over a mean follow-up time of 7.7 years. Risk for all-cause mortality was found increased in men with hyperferritinemia (194-598ng/ml) and no history of major chronic diseases compared with the reference group [fully-adjusted HR: 1.49 (95%CI 1.03–2.16)]. Among women, those in the lowest ferritin quartile (2-44ng/ml) had increased risk for all-cause mortality [fully-adjusted HR: 1.59 (95%CI 1.18–2.13)] compared with the reference group after adjustment for all covariates. Regarding cardiovascular mortality, we observed a positive association with ferritin levels in men, which was blunted after adjustment for inflammatory markers and lifestyle parameters. Men with no major chronic diseases who were in the highest ferritin quartile had a significantly increased risk of cardiovascular mortality. No association between ferritin levels and cardiovascular mortality was detected in women.ConclusionCirculating ferritin levels showed sex-specific prognostic patterns. High ferritin levels in men with no major chronic disease and low ferritin levels in all women were associated with increased all-cause mortality after adjusting for covariates. High ferritin levels in men with no major chronic diseases were also independently associated with an increased risk of cardiovascular mortality. Future research is needed to clarify the prognostic role of ferritin.

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Section: Discussionmentioning

confidence: 99%

The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing

et al. 2017

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“…New guidelines from the American Heart Association and the Centers for Disease Control and Prevention (2003) advised doctors to consider testing Americans at moderate risk of heart disease for signs of inflammation in the bloodstream 29) . Ferritin has been identified as an acute phase inflammatory marker that, together with CRP and WBC, accelerates the oxidation of LDL, and induces inflammation in the blood vessels 5,30) . In the present analysis there was no significant difference in ferritin levels between the Statin use group and Non-use group.…”

Section: Discussionmentioning

confidence: 99%

“…readily measurable markers of inflammation and also identified as likely predictors of the risk of future cardiovascular disease and stroke [3][4][5] . Therapeutic intervention using inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, or "statins," has been demonstrated to reduce levels of inflammatory biomarkers independently of their effects on cholesterol.…”

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confidence: 99%

Effects of Statins on Serum Inflammatory Markers: The U.S. National Health and Nutrition Examination Survey 1999-2004

Yoon

Dillon

Carroll

et al. 2010

JAT

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“…17 The oxidized LDL induces inflammation in blood vessels, including the progression of atherosclerosis. 18 So it implies that serum ferritin indirectly enhances the role of LDL-cholesterol in the induction of cardiovascular diseases such as AMI.…”

Section: Discussionmentioning

confidence: 99%

Assessment of ferritin and its association with C - reactive protein and malondialdehyde in acute myocardial infarction

et al. 2015

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Background: There is increasing evidence that moderately elevated body iron stores, below levels commonly found in genetic hemochromatosis, may be associated with adverse health outcomes. Ferritin status has been implicated in atherosclerotic cardiovascular disease and hypothesis is that high iron status is associated with increased oxidation of LDL. The main objective of study is to evaluate the ferritin status and its association with C -reactive protein, malondialdehyde and serum lipids in acute myocardial infarction patients compared with healthy volunteers. Methods: Sixty seven acute myocardial infarction (AMI) patients in the age group of 30 to 50 years were selected for this study and 40 healthy age matched subjects were selected as control group. Diagnosis of AMI was made using guidelines of American College of Cardiology and European Society of Cardiology. The comprised group of 67 consecutive patients was divided based on the C -reactive protein (CRP) level into two groups (Group I <5 mg/L and Group II ≥5mg/L). Serum ferritin was assessed by ELISA method, C-reactive protein by turbilatex method and malondialdehyde (MDA) by Thiobarbituric Acid Reactive Substances (TBARS) method. Routine investigations were analysed by ERBA EM-360 fully automated analyzer. Results: The mean serum ferritin level was significantly increased in AMI patient groups compared with controls. The group II patients showed significantly increased serum ferritin levels compared to group I. In both the groups ferritin levels positively correlated with CRP and malondialdehyde. In group II serum ferritin levels showed positive correlation with serum Cholesterol, TGL, LDL and negative correlation with and HDL. In group I serum ferritin levels showed positive correlation with triglycerides and LDL and there was no statistical significant correlation with HDL and total cholesterol. Conclusions: Iron, an essential dietary constituent is now considered as a pro oxidant. Higher levels of ferritin, seems to be a strong risk factor for AMI. Regular monitoring of serum ferritin level can be useful in reducing cardiovascular morbidity and mortality.

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Relationship of Cardiovascular Risk Factors and Serum Ferritin with C-reactive Protein

Cited by 19 publications

References 20 publications

The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing

The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing

Effects of Statins on Serum Inflammatory Markers: The U.S. National Health and Nutrition Examination Survey 1999-2004

Assessment of ferritin and its association with C - reactive protein and malondialdehyde in acute myocardial infarction

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