2016
DOI: 10.1292/jvms.15-0295
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Relationship of bovine <i>NOS2</i> gene polymorphisms to the risk of bovine tuberculosis in Holstein cattle

Abstract: ABSTRACT. Many studies suggest significant genetic variation in the resistance of cattle and humans to infection with Mycobacterium bovis, the causative agent of zoonotic tuberculosis. The inducible nitric oxide synthase (iNOS which is encoded by the NOS2 gene) plays a key role in the immunological control of a broad spectrum of infectious agents. This study aimed to investigate the influence of genetic variations in the promoter of the NOS2 gene on bovine tuberculosis (bTB) susceptibility. In this study, the … Show more

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Cited by 12 publications
(11 citation statements)
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“…4b ). The core response includes numerous key genes known to be involved in the innate immune response against pathogenic mycobacteria such as: CCL20 [ 75 ]; IL18 , which limits the growth of M. tuberculosis in human macrophages [ 76–78 ]; anti-inflammatory IL10 [ 79 ]; and NOS2 , polymorphisms of which are associated with susceptibility of Holstein cattle to bovine TB [ 80 ] ( Fig. 4c ).…”
Section: Resultsmentioning
confidence: 99%
“…4b ). The core response includes numerous key genes known to be involved in the innate immune response against pathogenic mycobacteria such as: CCL20 [ 75 ]; IL18 , which limits the growth of M. tuberculosis in human macrophages [ 76–78 ]; anti-inflammatory IL10 [ 79 ]; and NOS2 , polymorphisms of which are associated with susceptibility of Holstein cattle to bovine TB [ 80 ] ( Fig. 4c ).…”
Section: Resultsmentioning
confidence: 99%
“…The association of enriched pathways such as Cytokine-cytokine receptor interaction, NOD-like receptor signalling and Jak-STAT signalling with this gene subset suggests a robust “core” macrophage response to infection with either mycobacterial species throughout the time course (Fig.4B). The core response includes numerous key genes known to be involved in the innate immune response against pathogenic mycobacteria such as: CCL20 (75); IL18, which limits the growth of M. tuberculosis in human macrophages (76-78); anti-inflammatory IL10 (79); and NOS2, polymorphisms of which are associated with susceptibility of Holstein cattle to bovine TB (80) (Fig.4C). Furthermore, the HIF-1 signalling pathway was significantly enriched for the DE genes common to both infection series; this pathway is associated with regulating a switch in central glucose metabolism during high-energy demanding events, such as infection, in neutrophils and macrophages (81)(Fig.S6A).…”
Section: Resultsmentioning
confidence: 99%
“…Polymorphisms in the human and bovine iNOS genes have also been linked to increased rates of M. tuberculosis and bTB respectively suggesting that variation in the NO response is field relevant434445. Moreover, iNOS-deficient mice are highly susceptible to TB infection, presenting with atypical granulomas that can facilitate mycobacterial reactivation, dissemination and transmission1246.…”
Section: Discussionmentioning
confidence: 99%