Relationship of bone morphogenetic proteins to disease activity and radiographic damage in patients with ankylosing spondylitis

Mc, Park; Yb, Park; Sk, Lee

doi:10.1080/03009740701774941

Cited by 45 publications

(40 citation statements)

References 12 publications

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“…Serum levels of BMP-2 and BMP-7 were elevated in AS patients, and BMP-7 correlated with radiographic change after a mean follow-up of 51.7 months [46].…”

Section: Biomarkers For Disease Prognosismentioning

confidence: 88%

Biomarkers in Spondyloarthritis

Maksymowych

2010

Curr Rheumatol Rep

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Key challenges in the management of spondyloarthritis focus on the lack of availability of measures of disease activity and the inability to predict joint damage or response to treatment, which is expensive and associated with potentially serious toxicity. Recent studies have focused on the possible contribution of soluble biomarkers, which have been selected based on current understanding of their role in inflammation and/or their association with turnover of joint matrix. Emerging candidates for disease activity markers include interleukin-6 and soluble cytotoxic T lymphocyte associated molecule-4. Potential predictors of damage include metalloproteinase-3 and sclerostin. Acute-phase reactants C-reactive protein and serum amyloid A and interleukin-6 are currently the best predictors of treatment response. Significant study limitations are small sample size and the lack of multivariate analyses that can determine whether the biomarker contributes information that is independent of other clinical and laboratory variables used in routine care.

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“…Serum levels of BMP-2 and BMP-7 were elevated in AS patients, and BMP-7 correlated with radiographic change after a mean follow-up of 51.7 months [46].…”

Section: Biomarkers For Disease Prognosismentioning

confidence: 88%

Biomarkers in Spondyloarthritis

Maksymowych

2010

Curr Rheumatol Rep

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“…These results indicated that BQZ may affect the osteogenic differentiation of fibroblasts by regulating Cx43. Overproduction of BMP-2 was noted in AS patients (30). BMP-2 is secreted mainly by osteoblasts, and the high levels of BMP-2 is AS patients may lead to new bone formation by stimulating the osteogenic differentiation of fibroblasts (31).…”

Section: Discussionmentioning

confidence: 99%

Bushen-Qiangdu-Zhilv decoction inhibits osteogenic differentiation of rat fibroblasts by regulating connexin 43

Zhou

Huang

Lin

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Bushen-Qiangdu-Zhilv (BQZ) decoction is a traditional Chinese medicinal compound widely used for treating ankylosing spondylitis (AS). However, the mechanisms underlying effects of BQZ remain largely unknown. Osteoblast differentiation of fibroblasts plays an important role in heterotopic ossification (HO) of AS, and connexin 43 (Cx43) is crucially involved in the osteoblast differentiation of fibroblasts. The aim of the present study was to evaluate the effects of BQZ on the osteogenic differentiation of fibroblasts by regulating Cx43. Rat fibroblasts were treated with freeze-dried powder of BQZ, in the presence or absence of recombinant human bone morphogenetic protein-2 (rhBMP-2). MTS assays were performed to examine the inhibitory effects of BQZ on fibroblast proliferation. Western blot assays were conducted to detect the protein expression of core-binding factor alpha 1 (Cbfα1), Cx43 and phosphorylated Cx43 (pCx43). BQZ appeared to inhibit fibroblast proliferation in a dose-dependent manner. Furthermore, the expression of Cbfα1 and Cx43/pCx43 was significantly suppressed by BQZ, with or without rhBMP-2 stimulation. Therefore, the present results indicate that BQZ may exert an anti-AS effect by suppressing the osteogenic differentiation of fibroblasts via Cx43 regulation.

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“…], for example, MMP3 is significantly associated with this endpoint and it is now under further evaluation 54,55,56,57,58 . Among imaging techniques, ultrasound was considered an interesting candidate for assessing SpA enthesitis as a marker of inflammatory activity both at site specific (entheses) and patient levels 59,60,61,62,63 .…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

Updating the OMERACT Filter: Implications for Imaging and Soluble Biomarkers

D'Agostino

Boers²,

Kirwan³

et al. 2014

J Rheumatol

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Objective. The Outcome Measures in Rheumatology (OMERACT) Filter provides a framework for the validation of outcome measures for use in rheumatology clinical research. However, imaging and biochemical measures may face additional validation challenges because of their technical nature. The Imaging and Soluble Biomarker Session at OMERACT 11 aimed to provide a guide for the iterative development of an imaging or biochemical measurement instrument so it can be used in therapeutic assessment. Methods. A hierarchical structure was proposed, reflecting 3 dimensions needed for validating an imaging or biochemical measurement instrument: outcome domain(s), study setting, and performance of the instrument. Movement along the axes in any dimension reflects increasing validation. For a given test instrument, the 3-axis structure assesses the extent to which the instrument is a validated measure for the chosen domain, whether it assesses a patient-centered or disease-centered variable, and whether its technical performance is adequate in the context of its application. Some currently used imaging and soluble biomarkers for rheumatoid arthritis, spondy-loarthritis, and knee osteoarthritis were then evaluated using the original OMERACT Filter and the newly proposed structure. Breakout groups critically reviewed the extent to which the candidate biomarkers complied with the proposed stepwise approach, as a way of examining the utility of the proposed 3-dimensional structure. Results. Although there was a broad acceptance of the value of the proposed structure in general, some areas for improvement were suggested including clarification of criteria for achieving a certain level of validation and how to deal with extension of the structure to areas beyond clinical trials. Conclusion. General support was obtained for a proposed tri-axis structure to assess validation of imaging and soluble biomarkers; nevertheless, additional work is required to better evaluate its place within the OMERACT Filter 2.0

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Relationship of bone morphogenetic proteins to disease activity and radiographic damage in patients with ankylosing spondylitis

Abstract: Overproduction of BMP-2 and BMP-7 was noted in AS patients, and serum BMP-7 levels reflected radiographic damage observed in AS.

Cited by 45 publications

References 12 publications

Biomarkers in Spondyloarthritis

Biomarkers in Spondyloarthritis

Bushen-Qiangdu-Zhilv decoction inhibits osteogenic differentiation of rat fibroblasts by regulating connexin 43

Updating the OMERACT Filter: Implications for Imaging and Soluble Biomarkers

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