Relationship of Blood Group Determinants on Helicobacter pylori Lipopolysaccharide with Host Lewis Phenotype and Inflammatory Response

Role for α- l -fucosidase in the control of Helicobacter pylori -infected gastric cancer cells

“…Further evidence obtained from knockout studies indicates that neither galE (UDP-galactose-4-epimerase) nor rfbM (GDP-mannose pyrophosphorylase) mutant strains (both genes are important for Le x biosynthesis) adhered to human gastric mucosal tissues whereas the Le x -positive parent strain adhered well to these tissues (17). Clinical studies in gastritis patients also yielded a similar conclusion (18). H. pylori strains that strongly express Le x/y are associated with higher-density colonization compared with strains that weakly express Le x/y (18).…”

“…The 2 results apparently correlated with each other. As previously mentioned, H. pylori strains strongly expressing Le x/y are linked to higher-density colonization, as compared to strains that weakly produce Le x/y (18). The pathogen thus likely evolves to develop various countermeasures against the host defense, suggesting an opposing interplay between H. pylori and the host.…”

An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection

“…Once a terminal O-antigen unit is Lewis y-glycosylated by FutC, further polymerization is blocked (13,15). Less frequently, H. pylori O-antigens may display Lewis a, Lewis b, and H-1 antigen, but such mimicry occurs in association with expression of Lewis x and Lewis y (14,19).…”

Helicobacter pylori isolates from Greek children express type 2 and type 1 Lewis and α1,6-glucan antigens in conjunction with a functional type IV secretion system

“…It has been well established that 80 % of cagA-positive H. pylori strains express Le x or Le y and more than half of them express both (Heneghan et al, 2000;Wirth et al, 1996). Previous studies also suggested that the expression of type 2 Le antigens by cagA-positive isolates could counterbalance their proinflammatory effects (Wirth et al, 1996).…”